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Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. De plus, nous expédions ESPL1 Kits (7) et et beaucoup plus de produits pour cette protéine.
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Human Monoclonal ESPL1 Primary Antibody pour IHC (p), ELISA - ABIN564183
Zhang, Ge, Meyer, Sethi, Basu, Pradhan, Zhao, Li, Cai, El-Naggar, Baladandayuthapani, Kittrell, Rao, Medina, Pati: Overexpression of Separase induces aneuploidy and mammary tumorigenesis. dans Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal ESPL1 Primary Antibody pour ICC, IF - ABIN151796
Chestukhin, DeCaprio: Western blot screening for monoclonal antibodies against human separase. dans Journal of immunological methods 2003
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Monoclonal ESPL1 Primary Antibody pour IF - ABIN534070
Chestukhin, Pfeffer, Milligan, DeCaprio, Pellman: Processing, localization, and requirement of human separase for normal anaphase progression. dans Proceedings of the National Academy of Sciences of the United States of America 2003
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Human Monoclonal ESPL1 Primary Antibody pour WB - ABIN151894
Sun, Kucej, Fan, Yu, Sun, Zou: Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner. dans Cell 2009
Human Polyclonal ESPL1 Primary Antibody pour DB, IHC (p) - ABIN389654
Haaß, Stehle, Nittka, Giehl, Schrotz-King, Fabarius, Hofmann, Seifarth: The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib. dans PLoS ONE 2012
Separase activity measurement may therefore be useful as a novel additional molecular marker for disease monitoring
Studies identified and characterized the role of separase in mitosis, meiosis, non-canonical roles, its regulation, as a regulator of centriole disengagement, non proteolytic roles, diverse substrates, structural insights, and association of separase with cancer. [review]
High ESP expression is associated with breast cancer.
Proximity mapping of human separase has been presented.
The assay was used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients.
Recruitment and activation of separase at centrosomes are two distinct steps that do not require microtubules.
Separase protein levels decrease and Separase proteolytic activity increases exclusively in b3a2 p210BCR-ABL (Montrer ABL1 Anticorps)-positive cell lines under Imatinib treatment.
Separase is an oncogene (Montrer RAB1A Anticorps) whose overexpression induces tumorigenesis, and indicate that Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human malignancies.
High ESPL1 mRNA expression was associated with luminal B breast cancers.
Data indicate that separase is subject to native-state cis (Montrer CISH Anticorps)/trans isomerization by peptidyl-prolyl-isomerase Pin1 (Montrer PIN1 Anticorps).
Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.
Separase-overexpressing mammary cells are not only susceptible to chromosomal missegregation-induced aneuploidy but also other genetic instabilities
With the continual loss of cohesins from chromosomes that occurs throughout the natural reproductive lifespan, tight regulation of separase in oocytes may be particularly important to maintain cohesion and prevent aneuploidy.
Separase act synergistically with loss of p53 (Montrer TP53 Anticorps) in the initiation and progression of B- and T- cell lymphomas
Separase phospho-regulation is critical for genome stability in oogenesis.
Separase phosphorylation act redundantly to prevent sister chromatid separation.
In embryonic fibroblasts, Separase depletion blocks sister chromatid separation but does not prevent other aspects of mitosis, cytokinesis, or chromosome replication.
Proteolytic activity of separase is therefore essential for Rec8 (Montrer REC8 Anticorps)'s removal from chromosome arms and for chiasma resolution but not for PBE (Montrer EHHADH Anticorps).
inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells
These results collectively suggest that Separase is an oncogene (Montrer RAB1A Anticorps), whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 (Montrer TP53 Anticorps) mutant background.
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009
caspase-like protein ESPL1
, extra spindle poles like 1
, extra spindle poles-like 1 protein
, separin, cysteine protease
, Cut1/ESP1 related protein