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ECM1 encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. De plus, nous expédions ECM1 Kits (56) et ECM1 Protéines (12) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal ECM1 Primary Antibody pour ELISA, EM - ABIN4306907
Tang, Tao, Yun-Liu, Sun, Geng, Jiang: Immunocytochemical localization of secretory component in Paneth cell secretory granules-rat Paneth cells participate in acquired immunity. dans Journal of molecular histology 2005
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This proteome analysis indicate that ECM1 is a potential novel plasma protein biomarker for the detection of primary ESCC and evaluation of neoplasms progression
The TT genotype of ECM1 gene rs3737240 SNP significantly increased susceptibility for Ulcerative Colitis and azathioprine use in Ulcerative Colitis patients in a Turkish population.
our work has identified a novel function of ECM1 in inhibiting Th17 cell differentiation in the experimental autoimmune encephalomyelitis model
ECM1, which displayed a high expression in hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) specimens, was closely associated with clinicopathologic data and may promote migration and invasion of HCC (Montrer FAM126A Anticorps) cells by inducing epithelia-mesenchymal transition.
Cell invasion (matrigel) was reduced only in the Hs578T cells (p < 0.01). Silencing decreased the expression of the prometastatic molecules S100A4 (Montrer S100A4 Anticorps) and TGFbetaR2 in both cell lines and CD44 (Montrer CD44 Anticorps) in Hs578T cells. We conclude that ECM1 is a key player in the metastatic process and regulates the actin cytoskeletal architecture of aggressive breast cancer cells at least in part via alterations in S100A4 (Montrer S100A4 Anticorps) and Rho A (Montrer RHOA Anticorps).
Overexpression of miR (Montrer MLXIP Anticorps)-486-3p inhibited cell growth and metastasis by targeting ECM1.
For 1q21 loci, we confirmed gene ECM1 as the most plausible gene from this region to be involved in pathogenesis of inflammatory bowel disease
In conclusion, the domain-specific anti-ECM1 MAbs produced in this study should provide a useful tool for investigating ECM1's biological functions, and cellular pathways in which it is involved.
Lipoid proteinosis is a rare autosomal recessive disorder caused by mutations in ECM1, encoding extracellular matrix protein 1, a glycoprotein expressed in many organs and which has important protein-protein interactions in tissue homeostasis
MMP-2 (Montrer MMP2 Anticorps) protein and ECM1 gene are useful preoperative markers for defining malignancy in suspicious thyroid nodules
ECM1 seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 rescues disorganized growth plates of PTHrP-null mice; ECM1 and progranulin (Montrer GRN Anticorps) chondrogenic growth factor constitute an interaction network.
HA accumulation primes the vasculature for atherosclerosis by crosslinking and reorganizing the extracellular matrix (ECM (Montrer MMRN1 Anticorps)) and by pushing VSMC differentiation towards a less mature phenotype.
Retinoid signaling in the stroma activates expression of Ecm1, which in turn down-regulates Ret (Montrer RET Anticorps) expression in the ureteric bud cleft, where bifurcation normally occurs and normal branching progresses.
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
secretory component p85
, extracellular matrix protein 1