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Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif.
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These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.
TDH, responsible for mitochondrial production of acetyl-CoA (Montrer LPCAT1 Protéines) in mouse embryonic stem cells, and the acetyltransferase GCN5L1 (Montrer BLOC1S1 Protéines) cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein (Montrer FBXO30 Protéines) transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
Fbxo15 mediates degradation of cardiolipin synthase1 in pneumonia.
Fbx15 is a novel target of Oct3/4 (Montrer POU5F1 Protéines) but is dispensable for embryonic stem cell self-renewal, development, and fertility.
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box protein 15
, F-box only protein 15
, f-box only protein 15-like