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FBXO2 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions F-Box Protein 2 Kits (39) et F-Box Protein 2 Protéines (8) et beaucoup plus de produits pour cette protéine.
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These results suggest that the FBXO2 variant rs9614 C allele may decrease the Parkinson Disease risk in mainland Han Chinese and may be a biomarker for PD.
summary, our findings suggest that FBXO2-regulated EMT (Montrer ITK Anticorps) led to carcinogenicity in gastric cancer and may be a novel target in the diagnosis and treatment of gastric cancer.
Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase has been presented.
This study provides new knowledge of the CFTR (Montrer CFTR Anticorps) biosynthetic pathway. It suggests that SYVN1 (Montrer SYVN1 Anticorps) and FBXO2 represent two distinct multiprotein complexes that may degrade DeltaF508-CFTR (Montrer CFTR Anticorps) in airway epithelia and identifies a new role for NEDD8 (Montrer NEDD8 Anticorps) in regulating DeltaF508-CFTR (Montrer CFTR Anticorps) ubiquitination.
Although the overall structure of FBG3 (Montrer FBXO44 Anticorps) is similar to that of Fbs1, the residues that form the Fbs1 carbohydrate-binding pocket failed to be superposed with the corresponding residues of FBG3 (Montrer FBXO44 Anticorps).
FBG1 degrades A1AT (Montrer SERPINA1 Anticorps)-Z through a Beclin1 (Montrer BECN1 Anticorps)-dependent arm of autophagy.
FBG1 is unique among known F-box proteins in that it contains a non-canonical D-Box within F-box domain, required for the growth arrest.
interaction of the HSV-1 UL9 protein with NFB42 results in its polyubiquitination and subsequent degradation by the 26S proteasome (Montrer Psmd4 Anticorps)
F-box only protein 2 (FBXO2), a substrate recognition component of the Skp1 (Montrer SKP1 Anticorps)-Cul1 (Montrer CUL1 Anticorps)-F-box protein (Montrer FBXO30 Anticorps) (SCF (Montrer KITLG Anticorps)) E3 ubiquitin ligase (Montrer MUL1 Anticorps) complex, was upregulated in livers of obese mice. Furthermore, using a protein purification approach combined with high-performance liquid chromatography/tandem mass spectrometry, we carried out a system-wide screening of FBXO2 substrates, in which the insulin receptor (IR (Montrer INSR Anticorps)) was identified as a substrate
The results of this study suggested that Fbxo2 controls the abundance and localization of specific NMDAR (Montrer GRIN1 Anticorps) subunits in the brain and may influence synapse formation and maintenance.
these results suggest that Fbxo2 regulates APP (Montrer APP Anticorps) levels and processing in the brain and may play a role in modulating Alzheimer disease pathogenesis.
our studies support a non-essential role for FBG1 on the degradation of torsinA (Montrer TOR1A Anticorps) and uncover a novel link of FBG1 to the autophagy pathway.
When expressed in hippocampal neurons, the Fbx2 dominant-negative mutant augmented NR1 subunit levels and NMDA receptor-mediated currents in an activity-dependent fashion
Fbs1 assists clearance of aberrant glycoproteins in neuronal cells by suppressing aggregates formation, independent of ubiquitin ligase activity, and thus functions as a unique chaperone for those proteins.
Our findings demonstrate that components of protein quality control are essential for inner ear homeostasis and implicate Fbx2 and Skp1 (Montrer SKP1 Anticorps) as potential genetic modifiers in age-related hearing loss.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.
F-box only protein 2
, F-box gene 1
, organ of Corti protein 1
, prion protein ligand 4
, neural F box protein NFB42