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FBXO25 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions F-Box Protein 25 Kits (12) et F-Box Protein 25 Protéines (7) et beaucoup plus de produits pour cette protéine.
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A sudy of FBXO25 gene expression patterns.
Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.
High FBXO25 expression is associated with non-small-cell lung cancer.
FBXO25 functions as a haploinsufficient tumor suppressor in mantle cell lymphoma.
FBXO25 mediates ELK-1 (Montrer ELK1 Anticorps) degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 (Montrer ELK1 Anticorps) pathway in response to mitogens
Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5 (Montrer NKX2-5 Anticorps), Isl1 (Montrer ISL1 Anticorps), and Hand1 (Montrer HAND1 Anticorps), indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development.
Beta-actin (Montrer ACTB Anticorps), physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments.
The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches.
our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 (Montrer NKX2-5 Anticorps) and Tbx5 (Montrer TBX5 Anticorps) ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 (Montrer NKX2-5 Anticorps) and Tbx5 (Montrer TBX5 Anticorps) transcriptional activity.
FBXO25 is a novel F-box protein (Montrer FBXO30 Anticorps) analogous to atrogin-1 (Montrer FBXO32 Anticorps), which is not involved in muscle atrophy.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
F-box protein 25
, F-box only protein 25
, f-box only protein 25-like
, F-box protein Fbx25