anti-F-Box Protein 32 (FBXO32) Anticorps

FBXO32 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions FBXO32 Kits (30) et FBXO32 Protéines (9) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FBXO32 114907 Q969P5
FBXO32 67731 Q9CPU7
FBXO32 171043 Q91Z62
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Top anti-FBXO32 Anticorps sur anticorps-enligne.fr

Showing 10 out of 88 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-FBXO32 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-FBXO32 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Jurkat cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Souris Chèvre Inconjugué ELISA, WB ABIN570946 (1 µg/mL) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
$255.00
Détails
Humain Chèvre Inconjugué ELISA, WB 0.1 mg Connectez-vous pour afficher 2 to 3 Days
$481.25
Détails
Humain Chèvre Inconjugué ELISA, WB 0.1 mg Connectez-vous pour afficher 7 to 9 Days
$485.88
Détails
Boeuf (Vache) Chèvre Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$610.50
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of Mouse heart lysate, using FBXO32 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277334 at 1/100 staining Mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat uterus labeled with Anti MAFbx/Fbx32 Polyclonal Antibody, Unconjugated (bs2591R) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Connectez-vous pour afficher 3 to 7 Days
$318.45
Détails
Humain Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 16 Days
$334.77
Détails

anti-FBXO32 Anticorps mieux référencés

  1. Human Polyclonal FBXO32 Primary Antibody pour ELISA, WB - ABIN451805 : Hanai, Cao, Tanksale, Imamura, Koshimizu, Zhao, Kishi, Yamashita, Phillips, Sukhatme, Lecker: The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. dans The Journal of clinical investigation 2007 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal FBXO32 Primary Antibody pour IF (p), IHC (p) - ABIN747698 : Lin, Hanson, Betik, Brennan-Speranza, Hayes, Levinger: Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 (PubMed)

Plus d’anticorps contre FBXO32 partenaires d’interaction

Zebrafish F-Box Protein 32 (FBXO32) interaction partners

  1. Atrogin-1 inactivation leads to progressive impairment of heart and skeletal muscle function and structure. Autophagy is severely impaired in Atrogin-1-deficient zebrafish embryos.

Rainbow Trout (Oncorhynchus mykiss) F-Box Protein 32 (FBXO32) interaction partners

  1. Results suggest that the up-regulation of FBXO32 is associated with skeletal and smooth muscle atrophy that occurs during fasting.

Human F-Box Protein 32 (FBXO32) interaction partners

  1. F-box only protein 32 (FBXO32) directly ubiquitinates C-terminal binding protein 1 (CtBP1 (Montrer CTBP1 Anticorps)), which is required for its stability and nuclear retention.

  2. Authors found that the FBXO32 and SMAD4 (Montrer SMAD4 Anticorps) levels were higher in normal tissues than in CRC (Montrer CALR Anticorps) tissues. The expressions of FBXO32 and SMAD4 (Montrer SMAD4 Anticorps) were related to clinicopathological parameters in CRC (Montrer CALR Anticorps).

  3. role of the muscle specific (Montrer EIF3K Anticorps) E3s MuRF-1 (Montrer TRIM63 Anticorps) and MAFbx in skeletal muscle wasting during various pathologies, as well as their regulation by modifiable lifestyle factors, were explored (review)

  4. FBXO32 activates NF-kappaB (Montrer NFKB1 Anticorps) through IkappaBalpha (Montrer NFKBIA Anticorps) degradation in inflammatory and genotoxic stress

  5. Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (Montrer MUL1 Anticorps) FBXO32/atrogin-1 and its transcription factor FOXO3A (Montrer FOXO3 Anticorps).

  6. Low FBXO32 expression is associated with breast cancer tumorigenesis.

  7. the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system

  8. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin (Montrer MYOCD Anticorps) ubiquitylation/degradation and its transcriptional activity.

  9. Our results indicate that abnormal SCF (Montrer KITLG Anticorps) activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy .

  10. Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.

Pig (Porcine) F-Box Protein 32 (FBXO32) interaction partners

  1. we speculated that the overexpression of FBXO32 is responsible for congenital splay leg syndrome and it plays an important role in the PI3K-Akt (Montrer AKT1 Anticorps) pathway

  2. this study shows that aspartate suppresses lipopolysaccharide-induced MAFbx expression in skeletal muscle via activation of Akt (Montrer AKT1 Anticorps) signaling, and inhibition of AMPKa and FOXO1 (Montrer FOXO1 Anticorps) signaling

  3. Porcine congenital splayleg (PCS) is a condition characterized by extensive fibre atrophy and raised fibre density. The combined differential expression of MAFbx and P311 (Montrer C5orf13 Anticorps) is of potential in the diagnosis of subclinical PCS.

Cow (Bovine) F-Box Protein 32 (FBXO32) interaction partners

  1. A study on the variability of bovine FBXO32 gene that is predictive of genetic potential for body length phenotype.

Mouse (Murine) F-Box Protein 32 (FBXO32) interaction partners

  1. Oligonol-mediated downregulation of Atrogin-1 and MuRF1 (Montrer TRIM63 Anticorps) gene expression alleviates muscle loss and improves the impaired myotube formation, indicating that oligonol supplementation may be useful for the attenuation of myotube loss.

  2. Indoxyl sulfate enhanced the production of atrogin-1 by enhancing oxidative stress in skeletal muscle, leading to muscle atrophy.

  3. Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (Montrer MUL1 Anticorps) FBXO32/atrogin-1 and its transcription factor FOXO3A (Montrer FOXO3 Anticorps).

  4. Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta (Montrer CEBPB Anticorps) binding to atrogin1 promoter locus in the myotubes.

  5. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin (Montrer MYOCD Anticorps) ubiquitylation/degradation and its transcriptional activity.

  6. educed PABPN1 (Montrer PABPN1 Anticorps) levels caused a consistent decline in distal PAS (Montrer PASK Anticorps) utilization in the 3'-UTR (Montrer UTS2R Anticorps) of a subset of OPMD-dysregulated genes. This alternative PAS (Montrer PASK Anticorps) utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 (Montrer PABPN1 Anticorps) levels caused a reduction in proteasomal activity, and transition in MyHC (Montrer MYH13 Anticorps) isotope expression pattern in myofibers.

  7. Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase (Montrer MUL1 Anticorps) mediated by the reduction of Akt (Montrer AKT1 Anticorps)-FOXO3a (Montrer FOXO3 Anticorps) signaling by oxidative stress.

  8. MAFbx mRNA expression was decreased in old mice relative to adult mice, whereas MuRF1 (Montrer TRIM63 Anticorps) mRNA expression was less affected by ageing

  9. Suggest role for atrogin-1 up-regulation in simvastatin-induced heart mitochondria dysfunction.

  10. Atrogin1 was upregulated in cancer cachexia mice. Atrogin1 knockdown protected skeletal muscle cells from TNF-alpha (Montrer TNF Anticorps) induced atrophy.

FBXO32 profil antigène

Profil protéine

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with FBXO32

  • F-box protein 32 (fbxo32) anticorps
  • F-box protein 32 (FBXO32) anticorps
  • F-box protein 32 (Fbxo32) anticorps
  • 4833442G10Rik anticorps
  • AI430017 anticorps
  • Atrogin1 anticorps
  • Fbx32 anticorps
  • Gm20361 anticorps
  • MAFbx anticorps
  • MGC56479 anticorps
  • zgc:56479 anticorps

Protein level used designations for FBXO32

F-box only protein 32 , atrogin-1 , F-box protein 32 , F-box only protein 32-like , atrogin 1 , muscle atrophy F-box protein , atrophy gene 1

GENE ID SPECIES
393891 Danio rerio
420343 Gallus gallus
464371 Pan troglodytes
475091 Canis lupus familiaris
704804 Macaca mulatta
100026040 Monodelphis domestica
100057506 Equus caballus
100142676 Ovis aries
100356177 Oryctolagus cuniculus
100387690 Callithrix jacchus
100462679 Salmo salar
100499214 Oncorhynchus mykiss
100580109 Nomascus leucogenys
114907 Homo sapiens
733657 Sus scrofa
513776 Bos taurus
67731 Mus musculus
171043 Rattus norvegicus
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