anti-F-Box Protein 4 (FBXO4) Anticorps

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions F-Box Protein 4 Kits (12) et F-Box Protein 4 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FBXO4 26272 Q9UKT5
FBXO4 106052 Q8CHQ0
FBXO4 310363  
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Top anti-F-Box Protein 4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 95 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-FBXO4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  293T cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-FBXO4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  OVCAR-3 cell lysate FBXO4 is supported by BioGPS gene expression data to be expressed in OVCAR3 WB Suggested Anti-FBXO4 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: OVCAR-3 cell lysate <br /> FBXO4 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Chèvre Inconjugué ELISA, IHC   100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Chèvre Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Lapin Inconjugué WB Western blot analysis of FBXO4 Antibody (Center) (ABIN653243) in Y79 cell line lysates (35 µg/lane). FBXO4 (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of FBXO4 Antibody (Center) in Y79 cell line lysates (35ug/lane). FBXO4 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Chèvre Inconjugué ELISA, IHC, IHC (p) Anti-FBXO4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962656 concentration 41396 ug/ml. Anti-FBXO4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué WB Immunocytochemistry staining of NIH-3T3 cells with ’s anti-FBX4. Cells were fixed in methanol/acetone followed by incubation with anti-FBX4 at a 1:300 dilution. Personal Communication. A, Diehl, Univ. of Pennsylvania, Philadelphia, 100 μL Connectez-vous pour afficher 7 to 9 Days
$389.00
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails
Boeuf (Vache) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails

anti-F-Box Protein 4 Anticorps mieux référencés

  1. Human Polyclonal FBXO4 Primary Antibody pour WB - ABIN233769 : Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. dans Molecular and cellular biology 2008 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal FBXO4 Primary Antibody pour EIA, WB - ABIN952288 : Zeng, Wang, Yang, Chen, Yang, Diehl, Liu, Lei: Structural basis of selective ubiquitination of TRF1 by SCFFbx4. dans Developmental cell 2010 (PubMed)
    Show all 3 Pubmed References

  3. Cow (Bovine) Polyclonal FBXO4 Primary Antibody pour WB - ABIN2774698 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... dans Molecular systems biology 2007 (PubMed)

  4. Cow (Bovine) Polyclonal FBXO4 Primary Antibody pour ELISA - ABIN4271628 : Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. dans Cancer cell 2008 (PubMed)

Plus d’anticorps contre F-Box Protein 4 partenaires d’interaction

Human F-Box Protein 4 (FBXO4) interaction partners

  1. in head and neck squamous cell carcinoma, fragile X mental retardation syndrome related protein 1 (Fxr1 (Montrer FXR1 Anticorps)) overexpression correlates with reduced F-box protein 4 (Fbxo4) levels.

  2. FBXO4 is the E3 ubiquitin ligase (Montrer MUL1 Anticorps) to interact with and promote Mcl-1 (Montrer MCL1 Anticorps) ubiquitination and degradation.

  3. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 (Montrer CCND1 Anticorps) degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 (Montrer CCND1 Anticorps) expression in human cancers.

  4. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.

  5. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.

  6. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.

  7. results reveal an atypical small GTPase (Montrer RACGAP1 Anticorps) domain within Fbx4 as a substrate-binding motif for SCF (Montrer KITLG Anticorps)(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 (Montrer TERF1 Anticorps) in telomere homeostasis control

  8. Fbx4 is a central regulator of Pin2/TRF1 (Montrer TERF1 Anticorps) protein abundance and alterations in the stability of Pin2/TRF1 (Montrer TERF1 Anticorps) can have a dramatic impact on telomere length

  9. SCF (Montrer KITLG Anticorps)(FBX4-alphaB crystallin (Montrer CRYAB Anticorps)) is an E3 ubiquitin ligase (Montrer MUL1 Anticorps) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (Montrer CCND1 Anticorps).

  10. Mutations in Fbx4 inhibit dimerization of the SCF (Montrer KITLG Anticorps)(Fbx4) ligase and contribute to cyclin D1 (Montrer CCND1 Anticorps) overexpression in human cancer.

Mouse (Murine) F-Box Protein 4 (FBXO4) interaction partners

  1. Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis

  2. This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.

  3. Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 (Montrer CCND1 Anticorps) deregulation and nuclear accumulation

  4. SCF (Montrer KITLG Anticorps)(FBX4-alphaB crystallin (Montrer CRYAB Anticorps)) is an E3 ubiquitin ligase (Montrer MUL1 Anticorps) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (Montrer CCND1 Anticorps).

  5. Lysine 269 is essential for cyclin D1 (Montrer CCND1 Anticorps) ubiquitylation by the SCF (Montrer KITLG Anticorps)(Fbx4/alphaB-crystallin (Montrer CRYAB Anticorps)) ligase.

F-Box Protein 4 (FBXO4) profil antigène

Profil protéine

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Gene names and symbols associated with anti-F-Box Protein 4 (FBXO4) Anticorps

  • F-box protein 4 (FBXO4) anticorps
  • F-box protein 4 (Fbxo4) anticorps
  • F-box protein 4 (fbxo4) anticorps
  • F-box protein 4 L homeolog (fbxo4.L) anticorps
  • 1700096C12Rik anticorps
  • AI851261 anticorps
  • AW494535 anticorps
  • fbx4 anticorps
  • FBXO4 anticorps
  • si:dkey-46a10.2 anticorps

Protein level used designations for anti-F-Box Protein 4 (FBXO4) Anticorps

F-box only protein 4 , F-box protein Fbx4 , F-box protein 4 , F-box only protein 4-like

GENE ID SPECIES
26272 Homo sapiens
106052 Mus musculus
310363 Rattus norvegicus
431586 Gallus gallus
489220 Canis lupus familiaris
534852 Bos taurus
548694 Xenopus (Silurana) tropicalis
697007 Macaca mulatta
737372 Pan troglodytes
100158284 Xenopus laevis
100406305 Callithrix jacchus
100600195 Nomascus leucogenys
100194812 Salmo salar
101116349 Ovis aries
100735926 Cavia porcellus
100319387 Danio rerio
100522958 Sus scrofa
100856557 Canis lupus familiaris
Fournisseurs de qualité sélectionnés pour anti-F-Box Protein 4 (FBXO4) Anticorps
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