F-Box Protein 7 Protéines (FBXO7)

FBXO7 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions F-Box Protein 7 Anticorps (33) et F-Box Protein 7 Kits (13) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
FBXO7 25793 Q9Y3I1
FBXO7 69754 Q3U7U3
Rat FBXO7 FBXO7 366854 Q68FS3
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days

FBXO7 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
Mouse (Murine)

Plus protéines pour F-Box Protein 7 (FBXO7) partenaires d'interaction

Zebrafish F-Box Protein 7 (FBXO7) interaction partners

  1. analysis of the zebrafish model of Fbxo7 mutations with a role in levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons

Human F-Box Protein 7 (FBXO7) interaction partners

  1. The pathological mechanisms concerning FBXO7-relevant protein aggregation, mitochondria impairment, reactive oxygen species (ROS) generation and mitophagy modulation in PARK15 pathogenesis are highlighted and discussed in the current review.

  2. we highlight the recent research on FBXO7, which advances our knowledge of the etiopathological pathways and fills unexpected gaps therein, justifying the dedicated study of rare variants of Parkinson disease--{REVIEW}

  3. Fbxo7 deficiency is associated with reduced cellular NAD(+) levels, which results in increased mitochondrial NADH redox index and impaired activity of complex I in the electron transport chain.

  4. Structure and function of Fbxo7 in Parkinson's disease has been summarized. (Review)

  5. Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

  6. Mutations in the F-box only protein 7 (FBXO7) gene, located on chromosome 22q12-q13, have been identified as having distinct clinical features in patients with hereditary Parkinson's disease (PD).

  7. The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated with autosomal recessive juvenile-onset Parkinson's disease We demonstrated wild-type FBXO7 is a stress response protein with both cytoprotective and neurotoxic roles

  8. This is first time a FBXO7 mutation has been identified that causes phenotype compatible with typical idiopathic Parkinson's disease and presents with some of its common nonmotor features

  9. High expression of PARK15 might lead to the occurrence of non-small-cell lung cancer.

  10. genetic analysis of this Turkish family and the Italian PARK15 family reported previously revealed that the c.1492C > T mutation is present on two different haplotypes in the Italian family

  11. in addition to the parkinsonian-pyramidal phenotype, in connection with FBXO7 mutations and points to an intrafamilial phenotypic variation

  12. Cys52 variant of FBXO7 may contribute to reduced Parkinson's disease susceptibility in Chinese

  13. The involvement of the FBXO7 gene in PD is very rare, at least in this population from southern Spain.

  14. The crystal structure of the Fbxo7 FP domain is reported at 2.0 A resolution. The Fbxo7 FP domain adopts an alpha/beta-fold similar to that of the PI31 FP domain.

  15. A mutational analysis of the FBXO7 gene in Taiwanese patients with Parkinson's disease (PD) does not show a potential pathophysiological role in PD.

  16. This study showed that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy.

  17. An important role is suggested for FBXO7 in the pathogenesis of synucleinopathies, including Parkinson's disease and multiple system atrophy.

  18. Mutations in FBX07 is often associated with rapidly progressive parkinsonism and with additional features including pyramidal signs, cognitive decline and loss of sustained Levodopa responsiveness.

  19. analysis of the zebrafish model of Fbxo7 mutations with a role in levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons

  20. [review] PARK15-associated parkinsonism, also referred to as parkinsonian-pyramidal disease (PPD), is caused by mutations in the F-box only protein 7 gene FBXO7.

Mouse (Murine) F-Box Protein 7 (FBXO7) interaction partners

  1. Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development.

  2. Taken together, this study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function.

  3. Report defective erythropoiesis in transgenic mouse with reduced Fbxo7 expression due to decreased erythrocyte p27 expression.

  4. 2 PDX models showed gained mutations such as PIK3CA or FBWX7 mutation. Ten patient-derived advanced colon cancer xenograft models were established.

  5. The physiological effect of reduced levels of Fbxo7 in mice showed significantly increased pro-B cell and pro-erythroblast populations, consistent with Fbxo7 having an anti-proliferative function and/or a role in promoting maturation of precursor cells.

  6. Fbxo7 specifically regulated D cyclin/cdk6 complexes; it was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers.

Profil protéine F-Box Protein 7 (FBXO7)

Profil protéine

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.

Gene names and symbols associated with F-Box Protein 7 Protéines (FBXO7)

  • F-box protein 7 (FBXO7)
  • F-box protein 7 L homeolog (fbxo7.L)
  • F-box protein 7 (fbxo7)
  • F-box protein 7 (FBP7)
  • F-box protein 7 (Fbxo7)
  • 2410015K21Rik Protéine
  • A230052G17Rik Protéine
  • AI117679 Protéine
  • ATFBP7 Protéine
  • AW260462 Protéine
  • C85118 Protéine
  • DKFZp469H0739 Protéine
  • F-box protein 7 Protéine
  • F8K7.20 Protéine
  • F8K7_20 Protéine
  • FBX Protéine
  • FBX07 Protéine
  • FBX7 Protéine
  • FBXO7 Protéine
  • MGC80085 Protéine
  • MGC135804 Protéine
  • MGC145325 Protéine
  • PARK15 Protéine
  • PKPS Protéine
  • si:ch211-286m4.2 Protéine
  • zgc:114096 Protéine

Protein level used designations for F-Box Protein 7 Protéines (FBXO7)

F-box only protein 7 , F-box protein 7 , F-box only protein 7-like

418063 Gallus gallus
474522 Canis lupus familiaris
446503 Xenopus laevis
470266 Pan troglodytes
717317 Macaca mulatta
780025 Xenopus (Silurana) tropicalis
838780 Arabidopsis thaliana
100016137 Monodelphis domestica
100135459 Papio anubis
100172444 Pongo abelii
100409679 Callithrix jacchus
100595350 Nomascus leucogenys
558097 Danio rerio
25793 Homo sapiens
100155281 Sus scrofa
508235 Bos taurus
100328739 Oryctolagus cuniculus
69754 Mus musculus
366854 Rattus norvegicus
101118684 Ovis aries
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