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FBXL2 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions FBXL2 Kits (12) et FBXL2 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FBXL2 Primary Antibody pour ELISA, IHC - ABIN249982
Ilyin, Rialland, Pigeon, Guguen-Guillouzo: cDNA cloning and expression analysis of new members of the mammalian F-box protein family. dans Genomics 2000
PTEN counteracts FBXL2 to promote IP3R3 (Montrer ITPR3 Anticorps)- and Ca(2 (Montrer CA2 Anticorps)+)-mediated apoptosis limiting tumour growth
these results uncover a previous unknown network involving FBXL2 and FoxM1 (Montrer FOXM1 Anticorps) in the regulation of gastric cancer growth.
FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation.
FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes.
These results suggested that the involvement of the reduction of FBL2 level is related to AD progression.
FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor
FBXL2 targets cyclin D2 (Montrer CCND2 Anticorps) for ubiquitination and degradation to inhibit leukemic cell proliferation.
FBL2 is a novel and dual regulator of amyloid precursor protein (APP (Montrer APP Anticorps)) metabolism through FBL2-dependent ubiquitination of APP (Montrer APP Anticorps).
FBXL2 mediates Aurora B (Montrer AURKC Anticorps) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
F-box protein FBL2/FBL3
, F-box protein containing leucine-rich repeats
, F-box/LRR-repeat protein 2
, F-box and leucine-rich repeat protein 20