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F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. De plus, nous expédions FBXW2 Kits (13) et FBXW2 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FBXW2 Primary Antibody pour IHC (p), IHC - ABIN250000
Winston, Koepp, Zhu, Elledge, Harper: A family of mammalian F-box proteins. dans Current biology : CB 1999
Cow (Bovine) Polyclonal FBXW2 Primary Antibody pour WB - ABIN2774691
Yang, Yu, Chuang, Chang, Chang, Yao, Chen: FBW2 targets GCMa to the ubiquitin-proteasome degradation system. dans The Journal of biological chemistry 2005
Show all 2 Pubmed References
BTrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation.
RACK1 (Montrer GNB2L1 Anticorps) competes with GCM1 (Montrer GCM1 Anticorps) for FBW2 and thereby prevents GCM1 (Montrer GCM1 Anticorps) ubiquitination, which is also supported by the observation that GCM1 (Montrer GCM1 Anticorps) is destabilized in RACK1 (Montrer GNB2L1 Anticorps)-knockdown BeWo placental cells
the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system
UBE2D2 (Montrer UBE2D2 Anticorps) is required for GCMa (Montrer GCM1 Anticorps) ubiquitination and for association with the SCF (Montrer KITLG Anticorps)(FBXW2) complex.
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
F-box and WD repeat domain containing 2
, F-box and WD-40 domain protein 2
, F-box and WD-40 domain-containing protein 2
, F-box/WD repeat-containing protein 2