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F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. De plus, nous expédions FBXW2 Anticorps (50) et FBXW2 Protéines (5) et beaucoup plus de produits pour cette protéine.
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RACK1 (Montrer GNB2L1 Kits ELISA) competes with GCM1 for FBW2 and thereby prevents GCM1 ubiquitination, which is also supported by the observation that GCM1 is destabilized in RACK1 (Montrer GNB2L1 Kits ELISA)-knockdown BeWo placental cells
the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system
UBE2D2 is required for GCMa ubiquitination and for association with the SCF (Montrer KITLG Kits ELISA)(FBXW2) complex.
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
F-box and WD repeat domain containing 2
, F-box and WD-40 domain protein 2
, F-box and WD-40 domain-containing protein 2
, F-box/WD repeat-containing protein 2