Profil protéine

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds\; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Gene names and symbols associated with FBXW4

• F-box and WD repeat domain containing 4 (fbxw4) anticorps
• F-box and WD repeat domain containing 4 (FBXW4) anticorps
• F-box and WD repeat domain containing 4 (Fbxw4) anticorps
• F-box and WD-40 domain protein 4 (Fbxw4) anticorps

• Dac anticorps
• dactylin anticorps
• dactylyn anticorps
• Fbw4 anticorps
• FBWD4 anticorps
• Afficher tous les alias de synonymes
• FBXW4 anticorps
• hag anticorps
• hagoromo anticorps
• SHFM3 anticorps
• SHSF3 anticorps
• wu:fk63g06 anticorps

Protein level used designations for FBXW4

F-box/WD repeat-containing protein 4 , dactylaplasia , fk63g06 , F-box and WD repeat domain containing 4 , F-box and WD-40 domain protein 4 , F-box and WD-40 domain-containing protein 4 , F-box/WD repeat protein 4 , dactylin , F-box protein Fbw4 , protein hagoromo