F-Box and WD Repeat Domain Containing 5 Protéines (FBXW5)

FBXW5 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions FBXW5 Anticorps (48) et FBXW5 Kits (13) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
FBXW5 54461 Q969U6
Rat FBXW5 FBXW5 362081 Q4KLI9
FBXW5 30839 Q9QXW2
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Showing 3 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails

FBXW5 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour F-Box and WD Repeat Domain Containing 5 (FBXW5) partenaires d'interaction

Human F-Box and WD Repeat Domain Containing 5 (FBXW5) interaction partners

  1. Here, the authors show that the F-box protein FBXW5 targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients. In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, inhibiting SEC23B degradation.

  2. oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2

  3. DLC1 was ubiquitinated and degraded by cullin 4A-RING ubiquitin ligase (CRL4A) complex interaction with DDB1 and the FBXW5 substrate receptor.

  4. Identify Fbxw5-driven fluctuation of Eps8 levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis.

  5. Fbxw5 enhances sumoylation of nuclear c-Myb

  6. FBXW5 levels are controlled by the anaphase-promoting (APC/C) complex, which targets FBXW5 for degradation during mitosis and G1, thereby helping to reset the centrosome duplication machinery.

  7. Results indicate that FBW5-DDB1-CUL4-ROC1 is an E3 ubiquitin ligase regulating TSC2 protein stability and TSC complex turnover.

  8. These results suggest that FBXW5 negatively regulates TAK1 in the IL-1beta signaling pathway.

Profil protéine FBXW5

Profil protéine

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Gene names and symbols associated with FBXW5

  • F-box and WD repeat domain containing 5 (FBXW5)
  • F-box and WD repeat domain containing 5 (Fbxw5)
  • F-box and WD-40 domain protein 5 (Fbxw5)
  • AI159739 Protéine
  • Fbw5 Protéine

Protein level used designations for FBXW5

F-box and WD-40 domain protein 5 , F-box/WD repeat-containing protein 5 , F-box and WD-40 domain-containing protein 5 , WD repeat-containing F-box protein FBW5 , F-box protein Fbw5

GENE ID SPECIES
417289 Gallus gallus
100514029 Sus scrofa
517357 Bos taurus
54461 Homo sapiens
362081 Rattus norvegicus
100732858 Cavia porcellus
30839 Mus musculus
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