anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) Anticorps

FAN1 encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. De plus, nous expédions FAN1 Kits (4) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FAN1 22909 Q9Y2M0
FAN1 330554 Q69ZT1
FAN1 309256  
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top anti-FAN1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 35 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: MTMR15 Antibody [NBP1-42677] - FFPE section of human ovarian carcinoma. Antibody used at a dilution of 1:250 Detection: DAB staining using Immunohistochemistry Accessory Kit. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué FACS, WB Western Blot at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis of MTMRF Antibody in K562 cell line lysates (35ug/lane) 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Alexa Fluor 594 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Souris Inconjugué IF, WB Western Blot analysis of KIAA1018 expression in transfected 293T cell line by KIAA1018 MaxPab polyclonal antibody.<br><br>Lane 1: KIAA1018 transfected lysate(58.63 KDa).<br>Lane 2: Non-transfected lysate.<br> KIAA1018 MaxPab polyclonal antibody. Western Blot analysis of KIAA1018 expression in human spleen. 50 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails
Humain Lapin Alexa Fluor 647 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Lapin Cy5 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Lapin Alexa Fluor 555 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Lapin Cy5.5 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Lapin HRP IHC (p), WB   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Lapin Alexa Fluor 488 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails

FAN1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , , ,
,

, , , , , , , , , , , , , , , ,
Mouse (Murine) ,


, , , , , , , , , , , , ,
Rat (Rattus) ,


, , , , , , , , , , , , ,

anti-FAN1 Anticorps mieux référencés

  1. Human Polyclonal FAN1 Primary Antibody pour IF, WB - ABIN524848 : Sareen, Chaudhury, Adams, Sobeck: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. dans Nucleic acids research 2012 (PubMed)

Plus d’anticorps contre FAN1 partenaires d’interaction

Human FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. hFAN1 homodimerization plays a role in biological processes that involve 5' DNA Flap (Montrer ALOX5AP Anticorps) cleavage.

  2. FAN1 (Montrer FSCN1 Anticorps) interaction with ubiquitylated PCNA (Montrer PCNA Anticorps) alleviates replication stress and preserves genomic integrity independently of BRCA2 (Montrer BRCA2 Anticorps)

  3. The structures, function, and proposed mechanisms of FAN1 (Montrer FSCN1 Anticorps) nuclease (Montrer DCLRE1C Anticorps) are discussed, and the insights into its role in interstrand cross-links repair and in processing of stalled replication forks are provided. [REVIEW]

  4. show that DNA repair genes (fan1 (Montrer FSCN1 Anticorps) and pms2 (Montrer PMS2 Anticorps)) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats

  5. FAN1 efficiently promoted DNA incision at the proper site of RPA-coated 5'-flapped DNA. Therefore, FAN1 possesses the ability to promote the ICL repair of 5'-flapped DNA covered by RPA.

  6. EXO1 (Montrer EXO1 Anticorps) and FEN1 (Montrer FEN1 Anticorps) cleaved the substrate at the boundary between the single-stranded 5' flap (Montrer ALOX5AP Anticorps) and the duplex, whereas FAN1 (Montrer FSCN1 Anticorps) incised it three to four nucleotides in the double-stranded region.

  7. Detected FAN1 (Montrer FSCN1 Anticorps) mutations in approximately 3% of families who met the Amsterdam criteria for hereditary colorectal cancer and had mismatch repair-proficient cancers with no previously associated mutations.

  8. The crystal structures of human FAN1 (Montrer FSCN1 Anticorps) in complex with a 5' flap (Montrer ALOX5AP Anticorps) DNA substrate show that two FAN1 (Montrer FSCN1 Anticorps) molecules form a head-to-tail dimer to locate the lesion, orient the DNA, and unwind a 5' flap (Montrer ALOX5AP Anticorps) for subsequent incision.

  9. In this work, FAN1 (Montrer FSCN1 Anticorps)-DNA crystal structures and biochemical data reveal that human FAN1 (Montrer FSCN1 Anticorps) cleaves DNA successively at every third nucleotide

  10. Results show that FAN1 (Montrer FSCN1 Anticorps) utilizes its nuclease (Montrer DCLRE1C Anticorps) activity-in cooperation with the BLM (Montrer BLM Anticorps)-FANCD2 (Montrer FANCD2 Anticorps) complex-to promote replication fork restart and simultaneous suppression of new origin firing.

Mouse (Murine) FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. Our data show that Fan1 is involved in the physiologic response of kidney tubular cells to DNA damage, which contributes to the pathogenesis of chronic kidney disease. Moreover, Fan1(-/-) mice provide a new model with which to study the pathomechanisms of chronic kidney disease

  2. Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy

  3. ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance.

  4. Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.

FAN1 profil antigène

Profil protéine

This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with FAN1

  • FANCD2 and FANCI associated nuclease 1 (FAN1) anticorps
  • FANCD2/FANCI-associated nuclease 1 (Fan1) anticorps
  • FANCD2/FANCI-associated nuclease 1 (fan1) anticorps
  • FANCD2/FANCI-associated nuclease 1 (FAN1) anticorps
  • FANCD2 and FANCI associated nuclease 1 (Fan1) anticorps
  • 6030441H18Rik anticorps
  • fi39f01 anticorps
  • KIAA1018 anticorps
  • KMIN anticorps
  • mtmr15 anticorps
  • RGD1566323 anticorps
  • si:ch211-163b1.2 anticorps
  • si:ch211-201b11.2 anticorps
  • wu:fd06a07 anticorps
  • wu:fi39f01 anticorps

Protein level used designations for FAN1

coiled-coil domain-containing protein MTMR15 , fanconi anemia associated nuclease 1 , fanconi-associated nuclease 1 , myotubularin-related protein 15 , myotubularin related protein 15 , Fanconi-associated nuclease 1

GENE ID SPECIES
22909 Homo sapiens
330554 Mus musculus
565458 Danio rerio
100481860 Ailuropoda melanoleuca
415383 Gallus gallus
479017 Canis lupus familiaris
100154519 Sus scrofa
508171 Bos taurus
309256 Rattus norvegicus
Fournisseurs de qualité sélectionnés pour anti-FAN1 (FAN1) Anticorps
Avez-vous cherché autre chose?