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FAN1 encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. De plus, nous expédions FAN1 Kits (4) et et beaucoup plus de produits pour cette protéine.
Showing 10 out of 35 products:
Human Polyclonal FAN1 Primary Antibody pour IF, WB - ABIN524848
Sareen, Chaudhury, Adams, Sobeck: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. dans Nucleic acids research 2012
hFAN1 homodimerization plays a role in biological processes that involve 5' DNA Flap (Montrer ALOX5AP Anticorps) cleavage.
FAN1 (Montrer FSCN1 Anticorps) interaction with ubiquitylated PCNA (Montrer PCNA Anticorps) alleviates replication stress and preserves genomic integrity independently of BRCA2 (Montrer BRCA2 Anticorps)
The structures, function, and proposed mechanisms of FAN1 (Montrer FSCN1 Anticorps) nuclease (Montrer DCLRE1C Anticorps) are discussed, and the insights into its role in interstrand cross-links repair and in processing of stalled replication forks are provided. [REVIEW]
show that DNA repair genes (fan1 (Montrer FSCN1 Anticorps) and pms2 (Montrer PMS2 Anticorps)) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats
FAN1 efficiently promoted DNA incision at the proper site of RPA-coated 5'-flapped DNA. Therefore, FAN1 possesses the ability to promote the ICL repair of 5'-flapped DNA covered by RPA.
EXO1 (Montrer EXO1 Anticorps) and FEN1 (Montrer FEN1 Anticorps) cleaved the substrate at the boundary between the single-stranded 5' flap (Montrer ALOX5AP Anticorps) and the duplex, whereas FAN1 (Montrer FSCN1 Anticorps) incised it three to four nucleotides in the double-stranded region.
Detected FAN1 (Montrer FSCN1 Anticorps) mutations in approximately 3% of families who met the Amsterdam criteria for hereditary colorectal cancer and had mismatch repair-proficient cancers with no previously associated mutations.
The crystal structures of human FAN1 (Montrer FSCN1 Anticorps) in complex with a 5' flap (Montrer ALOX5AP Anticorps) DNA substrate show that two FAN1 (Montrer FSCN1 Anticorps) molecules form a head-to-tail dimer to locate the lesion, orient the DNA, and unwind a 5' flap (Montrer ALOX5AP Anticorps) for subsequent incision.
In this work, FAN1 (Montrer FSCN1 Anticorps)-DNA crystal structures and biochemical data reveal that human FAN1 (Montrer FSCN1 Anticorps) cleaves DNA successively at every third nucleotide
Results show that FAN1 (Montrer FSCN1 Anticorps) utilizes its nuclease (Montrer DCLRE1C Anticorps) activity-in cooperation with the BLM (Montrer BLM Anticorps)-FANCD2 (Montrer FANCD2 Anticorps) complex-to promote replication fork restart and simultaneous suppression of new origin firing.
FAN1 plays important role in protecting against somatic expansions but is either not involved in protecting against intergenerational repeat expansions or is redundant with other related enzymes.
Our data show that Fan1 is involved in the physiologic response of kidney tubular cells to DNA damage, which contributes to the pathogenesis of chronic kidney disease. Moreover, Fan1(-/-) mice provide a new model with which to study the pathomechanisms of chronic kidney disease
Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy
ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance.
Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.
This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.
coiled-coil domain-containing protein MTMR15
, fanconi anemia associated nuclease 1
, fanconi-associated nuclease 1
, myotubularin-related protein 15
, myotubularin related protein 15
, Fanconi-associated nuclease 1