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FRMPD4 encodes a multi-domain (WW, PDZ, FERM) containing protein. De plus, nous expédions FERM and PDZ Domain Containing 4 Anticorps (13) et beaucoup plus de produits pour cette protéine.
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The findings point to an important role of FRMPD4 in normal cognitive development and function in humans and mice, and support the hypothesis that FRMPD4 mutations cause ID by disrupting dendritic spine morphogenesis in glutamatergic neurons.
Study suggests that the variant rs5979717 in FRMPD4 may play a role in schizophrenia etiology in females
A crystal structure of Frmpd4-bound LGN in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4.
Preso positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, PSD-95, and the betaPix-based Rac1 signaling pathway.
This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.
FERM and PDZ domain-containing protein 4
, FERM and PDZ domain containing 4
, FERM and PDZ domain-containing protein 4-like
, PDZ domain containing 10
, PDZ domain-containing protein 10
, PSD-95-interacting FERM and PDZ domain protein
, PSD-95-interacting regulator of spine morphogenesis