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FRMPD4 encodes a multi-domain (WW, PDZ, FERM) containing protein.
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Study suggests that the variant rs5979717 in FRMPD4 may play a role in schizophrenia etiology in females
A crystal structure of Frmpd4-bound LGN (Montrer GPSM2 Protéines) in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4.
Preso positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, PSD-95, and the betaPix-based Rac1 signaling pathway.
This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.
FERM and PDZ domain-containing protein 4
, FERM and PDZ domain containing 4
, FERM and PDZ domain-containing protein 4-like
, PDZ domain containing 10
, PDZ domain-containing protein 10
, PSD-95-interacting FERM and PDZ domain protein
, PSD-95-interacting regulator of spine morphogenesis