anti-FK506 Binding Protein 5 (FKBP5) Anticorps

The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. De plus, nous expédions FKBP5 Protéines (13) et FKBP5 Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FKBP5 2289 Q13451
FKBP5 14229 Q64378
FKBP5 361810  
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Top anti-FKBP5 Anticorps sur anticorps-enligne.fr

Showing 10 out of 153 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Chien Souris Inconjugué ICC, IF, WB FKBP51 HS Hela 10ug 1 in 1000 Western Blotting copy. 100 μg 3 to 4 Days
$471.90
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-FKBP5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. This image was taken for the unconjugated form of this product. ... 100 μL 11 to 14 Days
$727.83
Détails
Humain Souris Inconjugué IF, IHC (p), WB Western Blot analysis of FKBP5 expression in transfected 293T cell line by FKBP5 MaxPab polyclonal antibody.Lane 1: FKBP5 transfected lysate(50.27 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to FKBP5 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg 11 to 12 Days
$364.00
Détails
Humain Souris Inconjugué IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Détails
Chien Souris FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Tissue: MK cells. Species: Mouse. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000. Secondary Antibody: APC Goat Anti-Mouse (red). Counterstain: DAPI (blue) nuclear stain. Courtesy of: the Hospital Henri Mondor, France. Western Blot analysis of Human HeLa cell lysates showing detection of FKBP51 protein using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg 3 to 4 Days
$522.60
Détails
Chien Souris PerCP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Tissue: MK cells. Species: Mouse. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000. Secondary Antibody: APC Goat Anti-Mouse (red). Counterstain: DAPI (blue) nuclear stain. Courtesy of: the Hospital Henri Mondor, France. Western Blot analysis of Human HeLa cell lysates showing detection of FKBP51 protein using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg 3 to 4 Days
$531.70
Détails
Chien Souris APC ICC, IF, WB Western Blot analysis of Human HeLa cell lysates showing detection of FKBP51 protein using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Tissue: MK cells. Species: Mouse. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000. Secondary Antibody: APC Goat Anti-Mouse (red). Counterstain: DAPI (blue) nuclear stain. Courtesy of: the Hospital Henri Mondor, France. 100 μg 3 to 4 Days
$531.70
Détails
Chien Souris Atto 488 ICC, IF, WB Western Blot analysis of Human HeLa cell lysates showing detection of FKBP51 protein using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B . Tissue: MK cells. Species: Mouse. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody  at 1:1000. Secondary Antibody: APC Goat Anti-Mouse (red). Counterstain: DAPI (blue) nuclear stain. Courtesy of: the Hospital Henri Mondor, France. 100 μg 3 to 4 Days
$533.00
Détails

anti-FKBP5 Anticorps mieux référencés

  1. Human Polyclonal FKBP5 Primary Antibody pour IF, IHC (p) - ABIN515669 : Romano, Staibano, Greco, Brunetti, Nappo, Ilardi, Martinelli, Sorrentino, Di Pace, Mascolo, Bisogni, Scalvenzi, Alfano, Romano: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. dans Cell death & disease 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal FKBP5 Primary Antibody pour ICC, IF - ABIN261155 : Romano, DAngelillo, Staibano, Simeone, DArrigo, Ascierto, Scalvenzi, Mascolo, Ilardi, Merolla, Jovarauskaite, Romano: Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients. dans Pigment cell & melanoma research 2015 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal FKBP5 Primary Antibody pour ELISA, WB - ABIN560908 : van Lierop, Alkema, Laskewitz, Dijkema, van der Maaden, Smit, Plate, Conti, Jans, Timmers, van Boeckel, Lusher, McGuire, van Schaik, de Vlieg, Smeets, Hofstra, Boots, van Duin, Ingelse, Schoonen et al.: Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index. ... dans PLoS ONE 2012 (PubMed)

  4. Dog (Canine) Monoclonal FKBP5 Primary Antibody pour ICC, IF - ABIN361795 : Cheung-Flynn, Roberts, Riggs, Smith: C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. dans The Journal of biological chemistry 2003 (PubMed)
    Show all 6 Pubmed References

Plus d’anticorps contre FKBP5 partenaires d’interaction

Human FK506 Binding Protein 5 (FKBP5) interaction partners

  1. FKBP5 mRNA levels were significantly elevated as a result of chronic cocaine administration in the paraventricular nucleus and the bed nucleus of the stria terminalis.

  2. rs3800373 FKBP5 may increase the risk of developing predominantly depressed Bipolar Disorder.

  3. Associations of FKBP5 genotypes and state depression on the FKBP5 methylation levels of five CpG sites in intron 7.

  4. MiR410 was up-regulated in pediatric acute lymphoblastic leukemia (ALL) cases and cells. Bioinformatics analysis and luciferase reporter assay revealed FKBP5 as a direct target of miR410. The overexpression of miR410 accelerated the proliferation and colony formation ability of ALL cells, decreasing cell apoptosis rate by inhibiting activation of Akt signaling pathway. However, FKBP5 could reverse the effects of miR410.

  5. FKBP51 mRNA was found to mediate the link between anxiety and new-born cortisol.

  6. Study shows that a functional riboSNitch in the 3' untranslated region of FKBP5 alters microRNA-320a binding efficiency and mediates vulnerability to chronic post-traumatic pain.

  7. nominally, but not Bonferroni corrected significant associations, were found between the FKBP5 polymorphism rs1360780 and PTSD susceptibility among individuals affected by the Balkan wars; for elucidating this gene's real resilience/vulnerability potential, environmental influences should be taken into account

  8. The main finding of the present study was the association of one FKBP5 polymorphism (rs9470079-A) in major depression and obsessive-compulsive disorder and a reduced cortisol suppression response with very low doses of dexamethasone.

  9. The FKBP5 as a target of gene by environment interactions confers risk to psychopathology has increased in a short time

  10. This study shows, for the first time, the association between the rs4713916 polymorphism of the FKBP5 gene and different endpoints of Inhaled corticosteroids response in Chronic obstructive pulmonary disease patients.

  11. FKBP5 methylation may be a marker of higher metabolic risk in T2DM, possibly secondary to higher exposure to cortisol.

  12. Our findings demonstrate that FKBP5 and, specifically, its expression product FKBP51 are important modulators of antidepressant treatment outcome, pointing to a new, promising target for future antidepressant drug development.

  13. We assessed the effect of four SNPs (rs1360780, rs9470080, rs9296158, and rs4713902) on bedtime and awakening cortisol levels, emotional stress, and FKBP5 expression. Only variation in rs4713902 in females was shown to have significant effects (f=3.41, p=0.048) on FKBP5 expression. No significant genotype effect was observed on DNA methylation levels of CpG-1 or CpG-3

  14. study does not support the association of FKBP5 with obesity but demonstrates plausible implication of its variant in susceptibility to obesity-related insulin resistance and hypertriglyceridemia

  15. Borderline personality disorder (BPD) is associated with FKBP5 polymorphisms and several types of childhood abuse may modulate the effect between FKBP5 SNPs and this disorder.

  16. In this systematic review, a significant association was found with FKBP5 polymorphisms and suicidal behavior risk.

  17. FKBP51 has the potential to control inflammation.

  18. The central finding in our study is that although the FKBP5 risk allele and child abuse separately increased the risk for a posttraumatic stress disorder diagnosis in our sample of veterans, participants who reported a history of child abuse appeared to be far more likely to have a posttraumatic stress disorder diagnosis irrespective of whether they were FKBP5 risk allele carriers or not.

  19. This is the first study to quantify an overall gene-level effect of FKBP5 in a GxE analysis of Post Traumatic Stress Disorder.

  20. The higher the maltreatment load, the higher maternal hair cortisol and cortisone levels in T allele carriers of FKBP5 rs1360780 were observed. Hair cortisol and DHEA levels of newborns with the T allele were reduced with an increasing maternal maltreatment load, while there was an increase of hair cortisol and DHEA in newborns homozygous for the C allele.

Mouse (Murine) FK506 Binding Protein 5 (FKBP5) interaction partners

  1. Fkbp5 sequesters Cdk4 within the Hsp90 storage complex and prevents the formation of the cyclin D1-Cdk4 complex, which is a major inhibitor of differentiation.

  2. Adverse early life environment affects FKBP5 expression and FKBP5 mRNA variants, which in turn affect hypothalamus-pituitary-adrenal axis function and contributes to subsequent anxiety-like behavior later in life in mice.

  3. Study showed a reduction in long term potentiation in Fkbp5 knockout (KO) mice was observed when compared to wildtype mice, which correlated with changes to the glutamatergic and GABAergic signaling pathways.

  4. Overexpression of FKBP51 impaired long-term depression as well as spatial learning and memory.

  5. Fkbp5 knockouts are protected from high-fat diet-induced weight gain, show improved glucose tolerance and increased insulin signaling in skeletal muscle. We identify a novel association between FKBP51 and AS160, a substrate of AKT2 that is involved in glucose uptake. FKBP51 antagonism increases the phosphorylation of AS160.

  6. High FKBP5 expression is associated with anxiety/depression.

  7. In mice, dexamethasone 300 mug/kg was associated with increased amygdala Fkbp5 mRNA following fear extinction and robust extinction learning while lower doses were not associated with amygdala Fkbp5 mRNA or differences in extinction learning. Further, mice that extinguished on dexamethasone 300 mug/kg maintained low levels of freezing behavior during recall training while mRNA levels were no longer elevated.

  8. These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.

  9. Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.

  10. important regulator of PPARgamma in white adipose tissue

  11. FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice

  12. findings show that miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.

  13. These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.

  14. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).

  15. Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation, and its subsequent regulation of glucocorticoid receptor sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton

  16. the abundance of BDNF positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 in cells

  17. FKBP5 associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux

  18. Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice.

  19. Overexpression of FKBP51 in the amygdala resulted in increased anxiety-related behavior.

  20. the stress response, as well as the effects of antidepressants on behavior and autophagic markers, depends on FKBP51.

FKBP5 profil antigène

Profil protéine

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FKBP5

  • FK506 binding protein 5 (FKBP5) anticorps
  • FK506 binding protein 5 (fkbp5) anticorps
  • FK506 binding protein 5 (Fkbp5) anticorps
  • AIG6 anticorps
  • D17Ertd592e anticorps
  • Dit1 anticorps
  • FKBP-5 anticorps
  • FKBP5 anticorps
  • FKBP51 anticorps
  • FKBP54 anticorps
  • P54 anticorps
  • PPIase anticorps
  • Ptg-10 anticorps
  • si:zc263a23.8 anticorps
  • wu:fc31g11 anticorps
  • wu:fl87b03 anticorps
  • zgc:64082 anticorps

Protein level used designations for FKBP5

FK506 binding protein 5 , FK506-binding protein 5 , PPIase FKBP5 , peptidyl-prolyl cis-trans isomerase FKBP5 , rotamase , 51 kDa FK506-binding protein 5 , 51 kDa FKBP , 54 kDa progesterone receptor-associated immunophilin , FF1 antigen , FKBP-5 , FKBP-51 , HSP90-binding immunophilin , T-cell FK506-binding protein , androgen-regulated protein 6 , peptidylprolyl cis-trans isomerase , 51 kDa FK506-binding protein

GENE ID SPECIES
462639 Pan troglodytes
100171536 Pongo abelii
100544523 Meleagris gallopavo
100551895 Anolis carolinensis
100591277 Nomascus leucogenys
2289 Homo sapiens
14229 Mus musculus
361810 Rattus norvegicus
368924 Danio rerio
421186 Gallus gallus
481759 Canis lupus familiaris
100155423 Sus scrofa
535704 Bos taurus
100339155 Oryctolagus cuniculus
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