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When transfected into cell lines in which it is not expressed, suppresses cell growth. De plus, nous expédions FAM107A Anticorps (23) et FAM107A Kits (13) et beaucoup plus de produits pour cette protéine.
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FAM107A gene is down-regulated in laryngeal tumors.
This study has thus revealed a novel nuclear complex of F-actin, DRR1 and COMMD1 that is involved in NF-kappaB degradation and cell cycle suppression in neuroblastoma cells.
Importance of FAM107A in lung carcinogenesis, although other than promoter hypermethylation mechanism of the gene decreased expression.
Results found that DRR expression leads to elevated AKT activation by recruiting AKT to focal adhesios in a manner dependent on SRC-family kinases (SFKs) and cell adhesion.
DRR1 protein is expressed in normal cells, particularly in the nervous system during embryogenesis, is involved in neuronal cell survival, and is downregulated during neuroblastoma carcinogenesis.
Expression of the down-regulated in renal cell carcinoma gene (DRR1) gene at 3p14.2 was lost in 7 and down regulated in 2 "chr3+" tumours.
TU3A is epigenetically inactivated in human cancer
Endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region. Enhancement of DRR1 expression reduced spine density, diminished the probability of synaptic glutamate release, and altered cognitive performance.
When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.
uncharacterized protein LOC494764
, down-regulated in renal cell carcinoma 1
, family with sequence similarity 107 member A transcript
, protein FAM107A
, downregulated in renal cell carcinoma