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Required for proper chromosome congression and alignment during mitosis. De plus, nous expédions FAM83D Protéines (3) et beaucoup plus de produits pour cette protéine.
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FAM83D promotes HCC recurrence by promoting CD44 expression and CD44+ CSCs malignancy.
FAM83D knockdown up-regulated the protein expression level of F-box and WD repeat domain-containing 7 (FBXW7), but diminished the Notch1 protein expression level.
Higher level of FAM83D expression is positively correlated with an increase in genome instability in many cancer.
upregulation of FAM83D, a potential oncotarget gene, may be triggered by epigenetic events and can contribute to hepatocarcinogenesis
NMR-derived secondary chemical shifts and relaxation properties show that the Chica LC8 binding domain is essentially disordered with a dynamically restricted segment in one linker between motifs.
Taken together, these results demonstrate that FAM83D is a novel oncogene in HCC development and may constitute a potential therapeutic target in HCC.
Results demonstrate that FAM83D has prognostic value for breast cancer patients and is a novel oncogene in breast cancer development that at least in part acts through mTOR hyper-activation by inhibiting FBXW7.
interaction partner of the chromokinesin Kid that is required for the generation of polar ejection forces and chromosome congression
Required for proper chromosome congression and alignment during mitosis. Required for targeting KIF22/KID to the spindle microtubules (By similarity).
, spindle protein CHICA
, Protein FAM83D-A
, Protein FAM83D-B