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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). De plus, nous expédions FANCI Kits (4) et FANCI Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FANCI Primary Antibody pour WB - ABIN152583
Yuan, El Hokayem, Zhou, Zhang: FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. dans The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Polyclonal FANCI Primary Antibody pour IP, WB - ABIN253065
Colnaghi, Jones, Cotto-Rios, Schindler, Hanenberg, Huang: Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. dans Blood 2011
FANCI phosphorylation activates the FANCI/D2 complex.
Data suggest that FANCI and FANCD2 (Montrer FANCD2 Anticorps) have partially non-overlapping and possibly even opposing roles during the replication stress response.
Fanconi anemia (Montrer PALB2 Anticorps) FANCD2 (Montrer FANCD2 Anticorps) and FANCI proteins regulate the nuclear dynamics of splicing factors, such as SF3B1 (Montrer SF3B2 Anticorps).
FANCB (Montrer BRCA2 Anticorps) dimer coordinates FANCD2 (Montrer FANCD2 Anticorps):FANCI monoubiquitination by two FANCL (Montrer FANCL Anticorps) RING-ligases. Deubiquitination of FANCD2 (Montrer FANCD2 Anticorps):FANCI by USP1 (Montrer USP1 Anticorps):UAF1 (Montrer WDR48 Anticorps) occurs only when DNA is removed.
depletion of FANCI, but not FANCD2 (Montrer FANCD2 Anticorps) or USP1 (Montrer USP1 Anticorps), results in increased phosphorylation and activation of Akt (Montrer AKT1 Anticorps).
FANCI mutations are associated with Fanconi anemia (Montrer PALB2 Anticorps) in VACTERL association.
FANCJ (Montrer BRIP1 Anticorps) protein is important for the stability of FANCD2 (Montrer FANCD2 Anticorps)/FANCI proteins and protects them from proteasome and caspase-3 (Montrer CASP3 Anticorps) dependent degradation.
These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2 (Montrer FANCD2 Anticorps), and alter the current view of the FA-BRCA pathway.
these purification methods for human FANCI and FANCD2 (Montrer FANCD2 Anticorps) provide novel procedures to facilitate structural and biochemical studies of human FANCI and FANCD2 (Montrer FANCD2 Anticorps).
Results show that ATR (Montrer ANTXR1 Anticorps)-mediated phosphorylation of FANCI, controls dormant origin firing in response to DNA replication stress.
crystal structure of FANCI-FANCD2 (Montrer FANCD2 Anticorps)(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.
Fanconi anemia group I protein
, Fanconi anemia group I protein homolog