anti-Fanconi Anemia Complementation Group I (FANCI) Anticorps

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). De plus, nous expédions FANCI Kits (4) et FANCI Protéines (3) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FANCI 55215 Q9NVI1
Anti-Souris FANCI FANCI 208836 Q8K368
FANCI    
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Top anti-FANCI Anticorps sur anticorps-enligne.fr

Showing 10 out of 31 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB Western Blot: FANCI Antibody  - Detection of Human FANCI by Western Blot. Samples : Nuclear extract (5 and 20 ug) from HeLa cells. Antibody : Affinity purified rabbit anti-FANCI antibody used at 0.2 ug/ml. Detection : Chemiluminescence with an exposure time of 15 minutes. 100 μL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué IP, WB Western Blot and Immunoprecipitation: FANCI Antibody [ABIN253065] - Detection of Human FANCI by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- FANCI antibody ABIN253065 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. FANCI was also immunoprecipitated, albeit less efficiently, by another rabbit anti-FANCI antibody, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Western Blot: FANCI Antibody  - Detection of Human FANCI by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-FANCI antibody  used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cells, using FANCI antibody. 100 μL Connectez-vous pour afficher 16 Days
$334.77
Détails
Humain Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué WB Western blot of HeLa cell lysate showing specific immunolabeling of the ~150 kDa FANCI protein phosphorylated at Ser556 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by lysate treatment with lambda phosphatase (λ-Ptase, 800 units/1mg protein for 30 min). 100 μL Connectez-vous pour afficher 3 to 4 Days
$584.43
Détails
Chien Lapin Inconjugué IP, WB   100 μL Connectez-vous pour afficher 7 to 9 Days
$595.83
Détails
Humain Lapin Inconjugué IP, WB   100 μL Connectez-vous pour afficher 7 to 9 Days
$595.83
Détails
Humain Souris Inconjugué WB Western Blot analysis of FANCI expression in transfected 293T cell line by FANCI MaxPab polyclonal antibody.<br><br>Lane 1: FANCI transfected lysate(8.14 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μL Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: FANCI Antibody [NBP1-84608] - Staining of human testis shows strong nuclear positivity in cells in seminiferus ducts. Immunocytochemistry/Immunofluorescence: FANCI Antibody [NBP1-84608] - Staining of human cell line A-431 shows positivity in nucleus & plasma membrane. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Lapin Inconjugué ICC, IF Immunocytochemistry/Immunofluorescence: FANCI Antibody  - Staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol. 100 μL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails

anti-FANCI Anticorps mieux référencés

  1. Human Polyclonal FANCI Primary Antibody pour WB - ABIN152583 : Yuan, El Hokayem, Zhou, Zhang: FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. dans The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal FANCI Primary Antibody pour IP, WB - ABIN253065 : Colnaghi, Jones, Cotto-Rios, Schindler, Hanenberg, Huang: Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. dans Blood 2011 (PubMed)

Plus d’anticorps contre FANCI partenaires d’interaction

Human Fanconi Anemia Complementation Group I (FANCI) interaction partners

  1. Study reports the first structural insight into the human FANCD2 (Montrer FANCD2 Anticorps)-FANCI complex by obtaining the cryo-EM structure. The complex contains an inner cavity, large enough to accommodate a double-stranded DNA helix, as well as a protruding Tower domain. Disease-causing mutations in the Tower domain are observed in several Fanconi anemia (Montrer PALB2 Anticorps) patients.

  2. FANCI phosphorylation activates the FANCI/D2 complex.

  3. Data suggest that FANCI and FANCD2 (Montrer FANCD2 Anticorps) have partially non-overlapping and possibly even opposing roles during the replication stress response.

  4. Fanconi anemia (Montrer PALB2 Anticorps) FANCD2 (Montrer FANCD2 Anticorps) and FANCI proteins regulate the nuclear dynamics of splicing factors, such as SF3B1 (Montrer SF3B2 Anticorps).

  5. FANCB (Montrer BRCA2 Anticorps) dimer coordinates FANCD2 (Montrer FANCD2 Anticorps):FANCI monoubiquitination by two FANCL (Montrer FANCL Anticorps) RING-ligases. Deubiquitination of FANCD2 (Montrer FANCD2 Anticorps):FANCI by USP1 (Montrer USP1 Anticorps):UAF1 (Montrer WDR48 Anticorps) occurs only when DNA is removed.

  6. depletion of FANCI, but not FANCD2 (Montrer FANCD2 Anticorps) or USP1 (Montrer USP1 Anticorps), results in increased phosphorylation and activation of Akt (Montrer AKT1 Anticorps).

  7. FANCI mutations are associated with Fanconi anemia (Montrer PALB2 Anticorps) in VACTERL association.

  8. FANCJ (Montrer BRIP1 Anticorps) protein is important for the stability of FANCD2 (Montrer FANCD2 Anticorps)/FANCI proteins and protects them from proteasome and caspase-3 (Montrer CASP3 Anticorps) dependent degradation.

  9. These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2 (Montrer FANCD2 Anticorps), and alter the current view of the FA-BRCA pathway.

  10. these purification methods for human FANCI and FANCD2 (Montrer FANCD2 Anticorps) provide novel procedures to facilitate structural and biochemical studies of human FANCI and FANCD2 (Montrer FANCD2 Anticorps).

Mouse (Murine) Fanconi Anemia Complementation Group I (FANCI) interaction partners

  1. crystal structure of FANCI-FANCD2 (Montrer FANCD2 Anticorps)(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link

FANCI profil antigène

Profil protéine

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with FANCI

  • Fanconi anemia complementation group I (FANCI) anticorps
  • Fanconi anemia, complementation group I (Fanci) anticorps
  • KIAA1794 anticorps

Protein level used designations for FANCI

Fanconi anemia group I protein , Fanconi anemia group I protein homolog

GENE ID SPECIES
55215 Homo sapiens
208836 Mus musculus
Fournisseurs de qualité sélectionnés pour anti-FANCI (FANCI) Anticorps
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