Fanconi Anemia Complementation Group M (FANCM) Kits ELISA

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). De plus, nous expédions FANCM Anticorps (83) et et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
FANCM 57697 Q8IYD8
FANCM 104806 Q8BGE5
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
Détails
Souris < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
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Plus Kits ELISA pour FANCM partenaires d'interaction

Human Fanconi Anemia Complementation Group M (FANCM) interaction partners

  1. FANCM expression is a prognostic factor for overall survival in luminal B breast cancer in Chinese patients.

  2. Loss-of-function mutations in FANCM cause a cancer predisposition syndrome clinically distinct from bona fide FA. Care should be taken with chemotherapy and radiation treatments in these patients due to expected acute toxicity.

  3. Our data indicate that biallelic FANCM mutations do not cause classical FA, providing proof that FANCM is not a canonical FA gene. FANCM is a breast cancer-predisposing gene. Mutation testing of FANCM might be considered for individuals with the above-described clinical features.

  4. Two FANCM truncating mutations, the c.1432C>T (p.Arg478Ter) and c.1972C>T (p.Arg658Ter), were identified in two Male Breast Cancer cases (0.7%). When specifically considering cases at increased genetic risk for BC, FANCM mutation frequency raises up to 1%. Rare FANCM truncating mutations, other than c.5101C>T and c.5791C>T, may have a role in MBC susceptibility.

  5. Mutation in FANCM gene is associated with non-syndromic primary ovarian insufficiency.

  6. These results support the role of FANCM as a breast cancer susceptibility gene, particularly for triple-negative breast cancer.

  7. FANCM is actively recruited to the alternative lengthening of telomeres that are experiencing replication stress.

  8. we demonstrated that FANCM is a direct target of miR146a

  9. This case-control study included 2047 BRCA1 and BRCA2 (Montrer BRCA2 Kits ELISA)-negative familial breast cancer cases and 2187 controls and revealed an association of FANCM mutations with breast cancer. More pronounced associations were identified for early-onset (before age 51 years) breast cancer and triple-negative breast cancer.

  10. FANCM c.5101C > T nonsense mutation carriers have a reduced breast cancer survival but postoperative radiotherapy may diminish this survival disadvantage.

Mouse (Murine) Fanconi Anemia Complementation Group M (FANCM) interaction partners

  1. Fancm(Delta2/Delta2) mice also showed unique features atypical for Fanconi anemia (Montrer PALB2 Kits ELISA) mice, including underrepresentation of female Fancm(Delta2/Delta2) mice and decreased overall and tumor-free survival.

FANCM profil antigène

Antigen Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M.

Gene names and symbols associated with FANCM

  • Fanconi anemia complementation group M (FANCM) anticorps
  • hypothetical protein (PGTG_17854) anticorps
  • Fanconi anemia, complementation group M (Fancm) anticorps
  • AI427100 anticorps
  • C730036B14Rik anticorps
  • D12Ertd364e anticorps
  • FAAP250 anticorps
  • KIAA1596 anticorps

Protein level used designations for FANCM

Fanconi anemia complementation group M , fanconi anemia complementation group M , ATP-dependent RNA helicase FANCM , Fanconi anemia group M protein , fanconi anemia-associated polypeptide of 250 kDa , protein Hef ortholog , Fanconi anemia group M protein homolog

GENE ID SPECIES
513626 Bos taurus
10531976 Puccinia graminis f. sp. tritici CRL 75-36-700-3
57697 Homo sapiens
104806 Mus musculus
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