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The protein encoded by FAF2 is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. De plus, nous expédions Fas Associated Factor Family Member 2 Anticorps (59) et Fas Associated Factor Family Member 2 Protéines (8) et beaucoup plus de produits pour cette protéine.
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We present physiological evidence that UBXN3B positively regulates stimulator-of-interferon genes (STING) signaling. Mechanistic studies demonstrate that UBXN3B interacts with both STING and its E3 ligase TRIM56, and facilitates STING ubiquitination, dimerization, trafficking, and consequent recruitment and phosphorylation of TBK1.
UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain.
that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis
role of UBXD8 in cellular responses to excess fatty acids
the UAS domain of Ubxd8 mediates it's polymerization upon interaction with long-chain unsaturated fatty acids
UBXD8-mediated recruitment of p97/VCP to LDs increases lipid droplet (LD) size by inhibiting the activity of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis.
Ubx2 and Ubxd8 regulates lipid droplet homeostasis.
These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively.
These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids.
These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP proteins Ira2 (in yeast) and neurofibromin (in humans).
ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients
Ubxn3b(-/-), like Sting(-/-) mice, are highly susceptible to lethal herpes simplex virus 1 (HSV-1) and vesicular stomatitis virus (VSV) infection, which is correlated with deficient immune responses when compared to Ubxn3b(+/+) littermates.
The results indicate that although UBXD8 functionality can be largely compensated in the normal setting, it is crucial to sustain VLDL secretion when exposed to a dietary challenge of high fat.
Depletion of UBXD8 in hepatocytes suppresses VLDL secretion, and could lead to periportal steatosis when mice are fed a high-fat diet.
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
Fas associated factor family member 2
, UBX domain containing 8
, FAS-associated factor 2-like
, FAS-associated factor 2
, UBX domain protein 3B
, UBX domain-containing protein 3B
, UBX domain-containing protein 8
, expressed in T-cells and eosinophils in atopic dermatitis
, protein expressed in T-cells and eosinophils in atopic dermatitis
, FAS-associated factor 2-A
, UBX domain-containing protein 8-A