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FCRL5 encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. De plus, nous expédions Fc Receptor-Like 5 Anticorps (20) et Fc Receptor-Like 5 Protéines (5) et beaucoup plus de produits pour cette protéine.
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based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand.
we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism
this study revealed that the FCRL5+ tissue-like memory subset responds poorly to multiple stimuli compared with the FCRL5- subset, as reflected by reduced calcium mobilization and blunted cell proliferation
Data suggest that expression of FCRL5 (but not FCRL4) on surface of atypical (perhaps dysfunctional) memory B-Lymphocytes is up-regulated by exposure to Plasmodium falciparum antigens in subjects in Uganda where malaria is endemic.
FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs.
FcRL5 binds all immunoglobulin (Ig)G isotypes with varied efficiency.
Enhanced proliferation and downstream isotype expression upon FCRL5 stimulation could reflect a physiological role for FCRL5 in the expansion and development of antigen-primed B cells.
Three of the FCRL5 tag SNPs, rs6667109, rs3811035 and rs6692977 showed association with Graves' disease. association with FCRL5 was secondary to linkage disequilibrium with the FCRL3, rs11264798 and rs10489678 SNPs.
Characterization and comparison of the structure and B-cell expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome.
IRTA2 is expressed on the surface of human lymphoma cell lines and hairy cell leukemia cells
results identify FcRH5 as a novel, direct target of EBNA2 that may contribute to the development of Epstein-Barr virus-associated tumors
IRTA2/FcRH5 may have a role in hairy cell leukemia
Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
Down-regulation of FCRL5 is associated with acute lymphoblastic leukemia.
Single-nucleotide polymorphism in the FCRL5 gene and HLA-B27 is associated with ankylosing spondylitis.
FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.
The three amino-terminal immunoglobulin domains of FCRL5 are required for binding of orthopoxvirus histocompatibility class I-like protein to B cells and monocytes/macrophages.
a novel immunoregulatory marker of splenic marginal zone and B1 type B lineage cells.
Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment.
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Fc receptor-like 5
, fc receptor-like protein 5-like
, Fc receptor-like protein 5-like
, Fc receptor-like protein 5
, fc receptor homolog 5
, fcR-like protein 5
, immune receptor translocation-associated protein 2
, immunoglobulin superfamily receptor translocation associated 2 (IRTA2)
, BXMAS1-like protein 2
, Fc receptor-like protein 3
, fc receptor homolog 3