Fermitin Family Member 1 (FERMT1) Kits ELISA

FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. De plus, nous expédions FERMT1 Anticorps (47) et FERMT1 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
FERMT1 55612 Q9BQL6
FERMT1 241639 P59113
Anti-Rat FERMT1 FERMT1 296179  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Souris 78-5000 pg/mL   96 Tests Connectez-vous pour afficher 2 to 3 Days
$867.90
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Humain
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$1,029.60
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Plus Kits ELISA pour FERMT1 partenaires d'interaction

Human Fermitin Family Member 1 (FERMT1) interaction partners

  1. we demonstrated that Kindlin-1 promotes CRC (Montrer CALR Kits ELISA) progression by recruiting SARA (Montrer ZFYVE9 Kits ELISA) and Smad3 (Montrer SMAD3 Kits ELISA) to TbetaRI (Montrer TGFBR1 Kits ELISA) and thereby activates TGF-beta (Montrer TGFB1 Kits ELISA)/Smad3 (Montrer SMAD3 Kits ELISA) signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta (Montrer TGFB1 Kits ELISA)/Smad3 (Montrer SMAD3 Kits ELISA) signaling and may also be a potential target for CRC (Montrer CALR Kits ELISA) therapeutics.

  2. Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions

  3. these data define a novel role for Kin1 in microtubule acetylation and stability

  4. keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.

  5. FERMT1 activates the beta-catenin (Montrer CTNNB1 Kits ELISA) transcriptional activity to promote EMT (Montrer ITK Kits ELISA) in CC metastasis.

  6. KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.

  7. We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 (Montrer FERMT2 Kits ELISA) overexpression has no compensatory effect.

  8. These results indicate that Kindlin-1 is essential in EGF (Montrer EGF Kits ELISA)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (Montrer EGF Kits ELISA) in the treatment of acute wounds.

  9. KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS

  10. A nonsense mutation in Exon 5 of KIND1 Gene in an Iranian Family may lead to incomplete and non-functional protein products and is pathogenic and has meaningful implications for the diagnosis of patients with Kindler syndrome.

Mouse (Murine) Fermitin Family Member 1 (FERMT1) interaction partners

  1. these data define a novel role for Kin1 in microtubule acetylation and stability

  2. These results indicate that Kindlin-1 is essential in EGF (Montrer EGF Kits ELISA)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (Montrer EGF Kits ELISA) in the treatment of acute wounds.

  3. By modulating its affinity with kindlin, beta3 integrin (Montrer ITGB3 Kits ELISA) may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.

  4. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  5. Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (Montrer TGFB1 Kits ELISA) activation and Wnt (Montrer WNT2 Kits ELISA)-beta-catenin (Montrer CTNNB1 Kits ELISA) signal inhibition.

  6. Kindlin-1 and Kindlin-2 (Montrer FERMT2 Kits ELISA) have opposite roles in lung cancers

  7. Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.

  8. Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

Xenopus laevis Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (Montrer GUSB Kits ELISA) and eventual lethality by tadpole stages.

Zebrafish Fermitin Family Member 1 (FERMT1) interaction partners

  1. The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.

FERMT1 profil antigène

Antigen Summary

This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.

Gene names and symbols associated with FERMT1

  • fermitin family member 1 (FERMT1) anticorps
  • fermitin family member 1 (Fermt1) anticorps
  • fermitin family member 1 S homeolog (fermt1.S) anticorps
  • fermitin family member 1 (fermt1) anticorps
  • fermitin family homolog 1 (LOC100548276) anticorps
  • 5830467P10Rik anticorps
  • C20orf42 anticorps
  • DTGCU2 anticorps
  • KIND1 anticorps
  • Kindlin-1 anticorps
  • RGD1306816 anticorps
  • si:ch73-22c10.1 anticorps
  • UNC112A anticorps
  • URP1 anticorps
  • wu:fc32b07 anticorps

Protein level used designations for FERMT1

UNC112 related protein 1 , fermitin family homolog 1 , kindlerin , kindlin 1 , kindlin syndrome protein , unc-112-related protein 1 , UNC-112 related protein 1 , fermitin family member 1 , fermitin family homolog 1-like , fc32b07

GENE ID SPECIES
55612 Homo sapiens
241639 Mus musculus
296179 Rattus norvegicus
379119 Xenopus laevis
458088 Pan troglodytes
485775 Canis lupus familiaris
524427 Bos taurus
718297 Macaca mulatta
100407542 Callithrix jacchus
416727 Gallus gallus
100332544 Danio rerio
100466357 Ailuropoda melanoleuca
100492800 Xenopus (Silurana) tropicalis
100548276 Meleagris gallopavo
100051761 Equus caballus
100157961 Sus scrofa
100732971 Cavia porcellus
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