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FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain.
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Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin (Montrer PXN Kits ELISA).
we demonstrated that Kindlin-1 promotes CRC (Montrer CALR Kits ELISA) progression by recruiting SARA (Montrer ZFYVE9 Kits ELISA) and Smad3 (Montrer SMAD3 Kits ELISA) to TbetaRI (Montrer TGFBR1 Kits ELISA) and thereby activates TGF-beta (Montrer TGFB1 Kits ELISA)/Smad3 (Montrer SMAD3 Kits ELISA) signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta (Montrer TGFB1 Kits ELISA)/Smad3 (Montrer SMAD3 Kits ELISA) signaling and may also be a potential target for CRC (Montrer CALR Kits ELISA) therapeutics.
Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions
these data define a novel role for Kin1 in microtubule acetylation and stability
keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.
FERMT1 activates the beta-catenin (Montrer CTNNB1 Kits ELISA) transcriptional activity to promote EMT (Montrer ITK Kits ELISA) in CC metastasis.
KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.
We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 (Montrer FERMT2 Kits ELISA) overexpression has no compensatory effect.
These results indicate that Kindlin-1 is essential in EGF (Montrer EGF Kits ELISA)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (Montrer EGF Kits ELISA) in the treatment of acute wounds.
KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS
loss of Kindlin-1 leads to an imbalance in the cellular oxidative state, which renders Kindlin-1 deficient cells more prone to the effects of reactive oxygen species generated in response to oxidative stress
By modulating its affinity with kindlin, beta3 integrin (Montrer ITGB3 Kits ELISA) may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.
Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.
Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (Montrer TGFB1 Kits ELISA) activation and Wnt (Montrer WNT2 Kits ELISA)-beta-catenin (Montrer CTNNB1 Kits ELISA) signal inhibition.
Kindlin-1 and Kindlin-2 (Montrer FERMT2 Kits ELISA) have opposite roles in lung cancers
Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (Montrer GUSB Kits ELISA) and eventual lethality by tadpole stages.
The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.
This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.
UNC112 related protein 1
, fermitin family homolog 1
, kindlin 1
, kindlin syndrome protein
, unc-112-related protein 1
, UNC-112 related protein 1
, fermitin family member 1
, fermitin family homolog 1-like