anti-Fermitin Family Member 3 (FERMT3) Anticorps

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. De plus, nous expédions FERMT3 Kits (9) et FERMT3 Protéines (3) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FERMT3 108101 Q8K1B8
FERMT3 309186  
FERMT3 83706 Q86UX7
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Top anti-FERMT3 Anticorps sur anticorps-enligne.fr

Showing 10 out of 75 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 6 to 7 Days
$429.62
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB 100 μL Connectez-vous pour afficher 11 to 14 Days
$507.83
Détails
Roussette (Chauve-souris) Chèvre Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 11 to 14 Days
$610.50
Détails
Humain Lapin Inconjugué EIA, WB   0.1 mg Connectez-vous pour afficher 8 to 11 Days
$474.10
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Western Blot: URP2 Antibody [NBP2-20821] - Sample (30 ug of whole cell lysate) A: Jurkat B: Raji 7. 5% SDS PAGE gel, diluted at 1:1000. Immunohistochemistry-Paraffin: URP2 Antibody [NBP2-20821] - Immunohistochemical analysis of paraffin-embedded RT2 xenograft, using antibody at 1:500 dilution. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
$514.63
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, WB Western Blot: FERMT3/URP2 Antibody [NBP1-76349] - Rat spleen lysate with URP2 antibody at (A) 1 and (B) 2 ug/ml. Western Blot: FERMT3/URP2 Antibody  - Analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Connectez-vous pour afficher 8 to 11 Days
$485.88
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cells, using FERMT3 antibody. 100 μL Connectez-vous pour afficher 16 Days
$334.77
Détails
Humain Lapin Inconjugué IHC (p), WB 50 μg Connectez-vous pour afficher 12 to 14 Days
$685.40
Détails
Humain Chèvre Inconjugué ELISA, WB FERMT3 polyclonal antibody  (1 ug/mL) staining of human peripheral blood mononucleocytes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 11 to 12 Days
$374.13
Détails

anti-FERMT3 Anticorps mieux référencés

  1. Human Polyclonal FERMT3 Primary Antibody pour IF, WB - ABIN529478 : Feng, Li, Yau, Lee, Tang, Xue, Zhou, Lim, Cornvik, Ruedl, Shochat, Tan: Kindlin-3 mediates integrin ?L?2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1). dans The Journal of biological chemistry 2012 (PubMed)

  2. Human Polyclonal FERMT3 Primary Antibody pour ELISA, WB - ABIN4311346 : Svensson, Howarth, McDowall, Patzak, Evans, Ussar, Moser, Metin, Fried, Tomlinson, Hogg: Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. dans Nature medicine 2009 (PubMed)

Plus d’anticorps contre FERMT3 partenaires d’interaction

Mouse (Murine) Fermitin Family Member 3 (FERMT3) interaction partners

  1. Structure and lipid-binding properties of the kindlin-3 pleckstrin (Montrer PLEK Anticorps) homology domain has been reported.

  2. Mice expressing as little as 5% of kindlin-3 were viable and protected from spontaneous bleeding and infections. In vitro platelet functions, leukocyte adhesion, extravasation, and bacterial clearance were diminished. Bleeding time increased.

  3. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  4. Optimal T cell activation and B cell antibody responses in vivo require the interaction between Integrin beta2 and kindlin-3.

  5. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  6. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  7. the requirement of Kindlin-3 for effector T cells to induce alpha4beta1 and alphaLbeta2 integrin ligand binding and stabilization of integrin-ligand bonds is critical when integrin ligand levels are low, but of less importance when integrin ligand levels are high.

  8. This is the first in vivo demonstration that Kindlin-3-stabilized integrin adhesions, although essential for lymphocyte arrest on blood vessels and interstitial motility, are not obligatory for leukocyte diapedesis.

  9. the beta-2-integrin-kindlin-3 interaction is particularly important in adhesion strengthening under shear flow, and for T-cell homing to lymph nodes, but dispensable for T cell activation which occurs in a shear-free environment

  10. Kindlin-3 is central to conversion of mechanical force to intracellular signaling via calcium influx.

Xenopus laevis Fermitin Family Member 3 (FERMT3) interaction partners

Human Fermitin Family Member 3 (FERMT3) interaction partners

  1. FERMT3 regulates glioma cell activity through integrin-mediated Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling.

  2. this case report describes a female Thai patient who was diagnosed with leukocyte adhesion deficiency type III with a novel mutation in FERMT3, presenting with a humoral immune defect

  3. kindlin-3 plays an important role in maintaining a proper conformation of the resting alpha4beta1 to mediate both rolling and firm cell adhesion

  4. Kindlin-3 regulates c-Myc (Montrer MYC Anticorps) protein expression in the human chronic myeloid leukemia (Montrer BCL11A Anticorps) cell line K562.

  5. NMR studies demonstrated that the F1 loop of kindlin-3 is globally unfolded but stretches of residues assuming transient helical conformations could be detected in aqueous solution.

  6. Suppression of the Kindlin-2 (Montrer FERMT2 Anticorps)-integrin beta1-AKT (Montrer AKT1 Anticorps) regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR (Montrer MLXIP Anticorps)-200b in esophageal squamous cell carcinoma.

  7. Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 (Montrer ITGB2 Anticorps) suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall.

  8. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  9. A new C>T point mutation was found in exon 13 in the FERMT3 gene in an infant diagnosed with LAD (Montrer DLD Anticorps)-III. KINDLIN-3 expression is required for platelet aggregation and leukocyte function, but also osteoclast-mediated bone resorption.

  10. Mig-2 (Montrer FERMT2 Anticorps) significantly attenuates the antitumor action of cisplatin.

FERMT3 profil antigène

Profil protéine

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with FERMT3

  • fermitin family member 3 (Fermt3) anticorps
  • fermitin family member 3 L homeolog (fermt3.L) anticorps
  • fermitin family member 3 (fermt3) anticorps
  • fermitin family member 3 (FERMT3) anticorps
  • fermitin family member 3b (fermt3b) anticorps
  • C79673 anticorps
  • KIND3 anticorps
  • Kindlin3 anticorps
  • MGC69069 anticorps
  • MGC88900 anticorps
  • MIG-2 anticorps
  • MIG2B anticorps
  • RGD1310168 anticorps
  • UNC112C anticorps
  • URP2 anticorps
  • URP2SF anticorps
  • zgc:64101 anticorps

Protein level used designations for FERMT3

fermitin family homolog 3 , unc-112-related protein 2 , fermitin family member 3 , MIG2-like protein , UNC-112 related protein 2 , kindlin 3 , kindlin-3

GENE ID SPECIES
108101 Mus musculus
309186 Rattus norvegicus
379715 Xenopus laevis
448215 Xenopus (Silurana) tropicalis
483766 Canis lupus familiaris
100050011 Equus caballus
83706 Homo sapiens
525159 Bos taurus
393878 Danio rerio
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