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FATE1 encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis.
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Human Polyclonal FATE1 Primary Antibody pour ICC, IF - ABIN4310683
Maxfield, Taus, Corcoran, Wooten, Macion, Zhou, Borromeo, Kollipara, Yan, Xie, Xie, Whitehurst: Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. dans Nature communications 2015
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In patients with ACC (Montrer ACACA Anticorps), FATE1 expression in their tumor is inversely correlated with their overall survival. the ER-mitochondria uncoupling activity of FATE1 is harnessed by cancer cells to escape apoptotic death and resist the action of chemotherapeutic drugs.
FATE1 is a key survival factor in multiple oncogenic backgrounds. FATE1 prevents the accumulation of the stress-sensing BH3-only (Montrer BBC3 Anticorps) protein, BCL-2-Interacting Killer (BIK (Montrer BIK Anticorps)), thereby permitting viability in the presence of toxic stimuli.
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation.
, cancer/testis antigen 43
, fetal and adult testis expressed transcript protein
, fetal and adult testis-expressed transcript protein
, tumor antigen BJ-HCC-2
, fetal and adult testis expressed 1
, fetal and adult testis-expressed transcript protein homolog
, fetal and adult testis expressed transcript