anti-Filamin C, gamma (FLNC) Anticorps

FLNC encodes one of three related filamin genes, specifically gamma filamin. De plus, nous expédions FLNC Kits (17) et FLNC Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FLNC 68794 Q8VHX6
FLNC 362332  
FLNC 2318 Q14315
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Top anti-FLNC Anticorps sur anticorps-enligne.fr

Showing 10 out of 50 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-FLNC Antibody Titration: 1.0 ug/ml Positive Control: HepG2 Whole Cell 100 μL 2 to 3 Days
$319.00
Détails
Humain Lapin Inconjugué ICC, IHC, WB 100 μL 13 to 16 Days
$245.00
Détails
Humain Souris Inconjugué ELISA, WB FLNC polyclonal antibody (A01), Lot # FAK0070504QCS1 Western Blot analysis of FLNC expression in NIH/3T3 . 50 μL 11 to 12 Days
$238.67
Détails
Humain Lapin Inconjugué ICC, IHC, WB 100 μL 13 to 16 Days
$245.00
Détails
Humain Lapin Inconjugué IF (p), IHC (p) Paraformaldehyde-fixed, paraffin embedded Mouse heart, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with Filamin 2 Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining. 100 μL 14 to 21 Days
$327.80
Détails
Humain Lapin Inconjugué IF/ICC, IHC, IP, WB Western blot analysis of recombinant Human FLNC. IHC-P analysis of Human Prostate Gland Tissue, with DAB staining. 100 μg 11 to 18 Days
$436.16
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using FLNC antibody at 1:3000 dilution. 100 μL 6 to 11 Days
$390.55
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB   100 μL 11 to 14 Days
$581.17
Détails
Humain Lapin HRP IHC (p)   100 μL 14 to 21 Days
$430.10
Détails
Humain Lapin Alexa Fluor 555 IF (p)   100 μL 14 to 21 Days
$430.10
Détails

anti-FLNC Anticorps mieux référencés

  1. Human Polyclonal FLNC Primary Antibody pour ICC, IF - ABIN4312164 : Valdés-Mas, Gutiérrez-Fernández, Gómez, Coto, Astudillo, Puente, Reguero, Álvarez, Morís, León, Martín, Puente, López-Otín: Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy. dans Nature communications 2014 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal FLNC Primary Antibody pour ELISA, WB - ABIN560923 : Sakane, Alamir Mahmoud Abdallah, Nakano, Honda, Kitamura, Imoto, Matsushita, Sasaki: Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. dans Genes to cells : devoted to molecular & cellular mechanisms 2013 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal FLNC Primary Antibody pour WB - ABIN2789843 : Begay, Tharp, Martin, Graw, Sinagra, Miani, Sweet, Slavov, Stafford, Zeller, Alnefaie, Rowland, Brun, Jones, Gowan, Mestroni, Garrity, Taylor: FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy. dans JACC. Basic to translational science 2016 (PubMed)

Plus d’anticorps contre FLNC partenaires d’interaction

Mouse (Murine) Filamin C, gamma (FLNC) interaction partners

  1. HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC

  2. The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis.

  3. Aciculin interacts with filamin C and Xin and is essential for myofibril assembly.

  4. KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere.

  5. filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population

  6. These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure.

  7. MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3

  8. Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity

Human Filamin C, gamma (FLNC) interaction partners

  1. Studied association of filamin C (FLNC) truncation mutations in a cohort of families with familial dilated cardiomyopathy(DCM); found FLNC truncating variants were present in 2.2% of DCM families and associated with high risk of life-threatening ventricular arrhythmias and a pathological cellular phenotype partially overlapping with arrhythmogenic right ventricular cardiomyopathy.

  2. Study identified two novel FLNC missense variants causing a distinct restrictive cardiomyopathy (RCM) phenotype in two families, and further demonstrated these variants lead to protein localization defects in vitro.

  3. Two rare variants in NKX2-5 and FLNC, carried by 1 in 2400 Icelanders, cause familial Dilated Cardiomyopathy (DCM) in Iceland. These genes have recently been associated with DCM. Given the serious consequences of these variants, we suggest screening for them in individuals with DCM and their family members, with subsequent monitoring of carriers, offering early intervention.

  4. Combination of in silico and experimental approaches revealed that FLNC missense variants localized in Ig-loop segments often lead to development of restrictive cardiomyopathy(RCM). The described FLNC mutations associated with early-onset RCMP extend cardiac spectrum of filaminopathies and facilitate the differential diagnosis of restrictive cardiac phenotype associated with neuromuscular involvement in children.

  5. Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells

  6. A novel familial truncating mutation in the filamin C gene was identified in a family with cardiac arrhythmias history.

  7. FLNC mutations were common in both hypertrophic cardiomyopathy patients and healthy population. Pedigree analysis showed that mutations were not well segregated with hypertrophic cardiomyopathy.

  8. we report a Chinese family suffering from filamin-C-related myofibrillar myopathy caused by a novel 15-bp deletion in exon 18 of the FLNC gene.

  9. Mutation in FLNC was identified as Restrictive Cardiomyopathy - causing mutation.

  10. a novel variant in FLNC was identified as pathogenic variant for familial Restrictive cardiomyopathy.

  11. The study confirms that truncating variants on myofibrillar myopathies- causing genes are frequently associated with dilated cardiomyopathies and also suggest that FLNC mutations could be considered as a common cause of dilated cardiomyopathy.

  12. Study found a novel splice-site mutation in FLNC gene (c.2389+1G>A) which co-segregated with all symptomatic individuals in the family with dilated cardiomyopathy (DCM). These results strongly suggest that the involvement of FLNC gene, due to haploinsufficiency, should be considered in familial cases with DCM, especially if accompanied with arrhythmia and increased incidence of sudden cardiac death.

  13. Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rac1/cdc42 activites in esophageal squamous cell carcinoma.

  14. Data show that the filamin C (FLNC) protein was significantly overexpressed with the development of hepatocellular carcinoma (HCC), which might play an important role in HCC invasion and metastasis.

  15. Missense variant in FLNC gene is associated with reading disability.

  16. suggest that the combination of the OBSCN p.Arg4444Trp variant and of the FLNC c.5161delG mutation, can cooperatively affect myofibril stability and increase the penetrance of muscular dystrophy in the French family

  17. This study therefore identifies both BAG3 reduction and autophagy promotion as potential therapies for FLNC(W2710X) myofibrillar myopathy, and identifies protein insufficiency due to sequestration, compounded by impaired autophagy, as the cause.

  18. Biallelic variants in FLNC can cause congenital dilated cardiomyopathy.

  19. Truncating mutations in FLNC caused an overlapping phenotype of dilated and left-dominant arrhythmogenic cardiomyopathies complicated by frequent premature sudden death

  20. a compelling evidence of the involvement of FLNC in the development of Hypertrophic Cardiomyopathy . Most of the FLNC variants were associated with mild forms ofHypertrophic Cardiomyopathy and a reduced penetrance

FLNC profil antigène

Profil protéine

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Filamin C, gamma (FLNC) Anticorps

  • filamin C (FLNC) anticorps
  • filamin C L homeolog (flnc.L) anticorps
  • filamin C (flnc) anticorps
  • filamin C, gamma (Flnc) anticorps
  • filamin C (Flnc) anticorps
  • 1110055E19Rik anticorps
  • ABP-280 anticorps
  • ABP280A anticorps
  • ABPA anticorps
  • ABPL anticorps
  • FLN2 anticorps
  • MFM5 anticorps
  • MPD4 anticorps

Protein level used designations for anti-Filamin C, gamma (FLNC) Anticorps

filamin C, gamma (actin binding protein 280) , gamma filamin , filamin C, gamma , filamin-C-like , ABP-280-like protein , ABP-L , FLN-C , actin binding protein 280 , actin-binding protein 280 , actin-binding-like protein , filamin, gamma , filamin-2 , filamin-C , gamma-filamin , ABP-L, gamma filamin , filamin 2 , 260kDa actin-binding protein , cgABP260 actin-binding domain

GENE ID SPECIES
463711 Pan troglodytes
734178 Xenopus laevis
100329116 Xenopus (Silurana) tropicalis
100475857 Ailuropoda melanoleuca
68794 Mus musculus
362332 Rattus norvegicus
2318 Homo sapiens
100730013 Cavia porcellus
100518997 Sus scrofa
482266 Canis lupus familiaris
528415 Bos taurus
395260 Gallus gallus
101104655 Ovis aries
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