anti-Forkhead Box P2 (FOXP2) Anticorps

FOXP2 encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. De plus, nous expédions FOXP2 Protéines (6) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FOXP2 93986 O15409
FOXP2 114142 P58463
FOXP2 500037 P0CF24
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Top anti-FOXP2 Anticorps sur

Showing 10 out of 136 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Chien Lapin Inconjugué IHC, WB WB Suggested Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 WB Suggested Anti-FOXP2 Antibody  Titration: 0.5ug/ml Positive Control: HepG2 cell lysate 100 μL 2 to 3 Days
Humain Chèvre Inconjugué ELISA, WB ABIN263146 (0.5µg/ml) staining of human cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN334400 (0.3µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
Humain Lapin Inconjugué WB Western blot analysis of FOXP2 using anti-FOXP2 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat brain tissue lysate, Lane 2: mouse brain tissue lysate, Lane 3: human SK-OV-3 whole Cell lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-FOXP2 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for FOXP2 at approximately 90KD. The expected band size for FOXP2 is at 80KD. 100 μg 4 to 6 Days
Boeuf (Vache) Chèvre Inconjugué IHC (p), WB   0.1 mg 4 to 8 Days
Cat Chèvre Inconjugué EIA, IHC (p), WB   0.1 mg 4 to 8 Days
Roussette (Chauve-souris) Chèvre Inconjugué ELISA, IHC, IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB 100 μL 11 to 14 Days
Humain Lapin Inconjugué IHC, IHC (p), IP, WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL 11 to 14 Days
Humain Lapin Inconjugué ELISA, WB Western blot analysis of FOXP2 expression in HeLa cells 100 μL 11 to 12 Days

anti-FOXP2 Anticorps mieux référencés

  1. Human Polyclonal FOXP2 Primary Antibody pour ICC, IHC (fro) - ABIN188687 : Lai, Fisher, Hurst, Vargha-Khadem, Monaco: A forkhead-domain gene is mutated in a severe speech and language disorder. dans Nature 2001 (PubMed)
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  2. Human Polyclonal FOXP2 Primary Antibody pour ICC, IF - ABIN4312409 : Enard, Gehre, Hammerschmidt, Hölter, Blass, Somel, Brückner, Schreiweis, Winter, Sohr, Becker, Wiebe, Nickel, Giger, Müller, Groszer, Adler, Aguilar, Bolle, Calzada-Wack, Dalke, Ehrhardt, Favor et al.: A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. ... dans Cell 2009 (PubMed)
    Show all 4 Pubmed References

  3. Polyclonal FOXP2 Primary Antibody pour IHC (p), IP - ABIN540995 : Lee, Shull, Frappart, Katyal, Enriquez-Rios, Zhao, Russell, Brown, McKinnon: ATR maintains select progenitors during nervous system development. dans The EMBO journal 2012 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal FOXP2 Primary Antibody pour ELISA, WB - ABIN263146 : Fujita, Sugihara: FoxP2 expression in the cerebellum and inferior olive: development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex. dans The Journal of comparative neurology 2011 (PubMed)
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  5. Human Monoclonal FOXP2 Primary Antibody pour ELISA, WB - ABIN969155 : Konopka, Bomar, Winden, Coppola, Jonsson, Gao, Peng, Preuss, Wohlschlegel, Geschwind: Human-specific transcriptional regulation of CNS development genes by FOXP2. dans Nature 2009 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal FOXP2 Primary Antibody pour ELISA, WB - ABIN969154 : Ptak, Enard, Wiebe, Hellmann, Krause, Lachmann, Pääbo: Linkage disequilibrium extends across putative selected sites in FOXP2. dans Molecular biology and evolution 2009 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal FOXP2 Primary Antibody pour IHC, ELISA - ABIN334400 : Fujita, Morita, Furuichi, Sugihara: Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre FOXP2 partenaires d’interaction

Human Forkhead Box P2 (FOXP2) interaction partners

  1. found that the deletion of any of these enhancers downregulates six well-known FOXP2 target genes in the SK-N-MC cell line

  2. Results showed that miR-222-3p induced DOX resistance via suppressing FOXP2, upregulating P-gp, and inhibiting the caspase pathway.

  3. In the presence of DNA, magnesium or calcium ions bind a single conserved binding pocket in the forkhead domain to promote a change in protein conformation that fosters the interaction between FOXP2 and DNA. In the absence of DNA, the metal ions bind this pocket weakly.

  4. FOXP2 knockdown attenuated the growth and invasiveness of triple-negative breast cancer cells as well as tumor progression and metastasis.

  5. FOXP2 rs10447760 polymorphism is associated with increased risk of schizophrenia in Caucasian but not Chinese populations.

  6. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.

  7. The change in dynamics of the hinge-loop region of FOXP2 alters the energetics and mechanism of DNA binding highlighting the critical role of hinge loop mutations in regulating DNA binding characteristics of the FOX proteins.

  8. FOXP2 is involved in the development of Orofacial Dyspraxia in Specific Language Impairment, highlighting the relevant role that the FOXP2-CNTNAP2 pathway plays in the emergence of language disorders.

  9. etiological mutations of FOXP1 and FOXP2, known to cause neurodevelopmental disorders, severely disrupted the interactions with FOXP-interacting transcription factors.

  10. Study investigated the effect of the FOXP2 mutation on Working Memory using members of the KE family; found mutation caused impairment in articulation that extends to working memory, presumably including the internal rehearsal of speech-based material, and that this extension of speech-related difficulty appears to be due to the same structural abnormalities that cause the articulatory disorder.

  11. To examine whether the variant in the FOXP2 gene contributes toward SCZ susceptibility, we carried out an association analysis of the SNP rs10447760 of the FOXP2 gene in a case-control study (1405 cases, 1137 controls) from China. We identified no association of rs10447760 in the FOXP2 gene with SCZ (P>0.05). A meta-analysis indicated that the SNP rs10447760 was not associated with susceptibility to SCZ in Han Chinese.

  12. These findings suggest a novel miR-23a/FOXP2 link contributing to pancreatic ductal adenocarcinoma development and invasion.

  13. Data confirmed that miR196b could directly bind to 3'UTR of FOXP2 mRNA and repress its expression. miR196b and FOXP2 showed a negative correlation in HCC tissues. More importantly, upregulation of FOXP2 antagonized miR196bmediated migration and invasion in Hep3B cells. Furthermore, FOXP2 knockdown partially reversed the antimetastatic function of the miR196b inhibitor on HCCLM3 cells.

  14. SNPs in WNT2 and FOXP2 are associated with clinical symptom severity of autism spectrum disorders.

  15. we have identified a novel de novo missense variant in FOXP1 that is identical to the most well-studied etiological variant in FOXP2. Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function.

  16. FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life.

  17. Our findings suggest that the FOXP2 rs10447760 polymorphism may not contribute to the development of schizophrenia, but may contribute to the clinical symptoms of schizophrenia among Han Chinese

  18. FOXP2 frontal cortex expression abnormalities were identified in Frontotemporal Degeneration patients.

  19. Increased frequency of FOXP2 expression significantly correlated with FOXP1-positivity, and FOXP1 co-immunoprecipitated FOXP2 from activated B-cell-diffuse large B-cell lymphoma (ABC-DLBCL) cells.

  20. These findings suggest that miR-139 plays a suppressive role in the regulation of osteosarcoma cell proliferation and migration via directly targeting FOXP2.

Mouse (Murine) Forkhead Box P2 (FOXP2) interaction partners

  1. Results strongly support critical roles of Foxp2 in the development of Ghrh-neurons and validate our finding of Foxp2 in the transcriptome of developing Ghrh-neurons.

  2. Findings show that Foxp2 can modulate different aspects of motor behaviour in distinct brain regions, and uncover an unknown role for Foxp2 in the modulation of Purkinje cell activity that severely impacts skilled movements.

  3. Study quantitatively analyzes the expression pattern of Foxp1 and Foxp2 with respect to specific cell types of projection neurons and interneurons in the striatum of adult mouse brains. Double immunostaining and in situ hybridization showed that Foxp1 and Foxp2 were specifically expressed in striatal projection neurons, but not in interneurons.

  4. Study shows that heterozygous loss of Foxp2 decreases excitatory (AMPA receptor-mediated) and increases inhibitory (GABA receptor-mediated) currents in D1 dopamine receptor positive MSNs of juvenile and adult mice.

  5. miR-34a and its target genes of FOXP2 and VAT1 are involved in dorsal root ganglia neuron damage under hyperglycemia.

  6. findings also indicate that Foxp2 helps to regulate strength and length of hind limbs and maintenance of joint cartilage and intervertebral discs, which are all anatomical features that are susceptible to adaptations for bipedal locomotion.

  7. Foxp2 has a putative HuR binding sites in the 3' UTR. Phosphorylation sites on HuR act in post-transcriptional regulation of Foxp2.

  8. The expression levels of Foxp2 were high in the posterior region and low in the anterior region of the thalamic primordium.

  9. Here, the authors show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity.

  10. Eesults indicate a role of FoxP2 differential expression in cell morphology control of the vertebrate telencephalon.

  11. that Foxp2-Mef2C signaling is critical to corticostriatal circuit formation

  12. Sumoylation of forkhead box P2 in neonatal mouse cerebellum regulates Purkinje cell development and motor functions and vocal communication, demonstrating evidence for sumoylation in regulating mammalian behaviors.

  13. we demonstrated for the first time that Foxp1 and Foxp2 are expressed during craniofacial development. Our data suggest that the Foxp genes may regulate development of the aboral and posterior regions of the jaw.

  14. Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.

  15. We show that Foxp1 and the androgen receptor are co-expressed in striatal medium spiny neurons and that brain-specific androgen receptor KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 expression and ultrasonic vocalizations

  16. The Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice.

  17. This study demonstrated that after middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs and suppression of the language-associated transcription factor, Forkhead box protein 2 (Foxp2).

  18. mice with Foxp2 mutations displayed quantitative differences in ultrasonic vocalizations as compared to wild-types

  19. Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function.

  20. Foxp2 was elevated early after stroke (at 6h), but significantly decreased 24h after injury in both the nucleus and the cytoplasm; neuronal Foxp2 expression increased in stroke mice compared to sham animals 4 weeks after injury

Zebrafish Forkhead Box P2 (FOXP2) interaction partners

  1. Our findings suggest that foxP2 is not necessary for axon pathfinding during development.

  2. foxP2 likely has a more general conserved role in nervous system development; molecular cloning

  3. The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.

  4. Domain-specific regulation of foxP2 CNS expression by lef1.

FOXP2 profil antigène

Profil protéine

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Gene names and symbols associated with anti-Forkhead Box P2 (FOXP2) Anticorps

  • forkhead box P2 (FOXP2) anticorps
  • forkhead box P2 (Foxp2) anticorps
  • forkhead box P2 (foxp2) anticorps
  • forkhead box P2 (foxP2) anticorps
  • lmw-gs (Foxp2) anticorps
  • forkhead box transcription factor (foxp1c) anticorps
  • forkhead box P2 L homeolog (foxp2.L) anticorps
  • 2810043D05Rik anticorps
  • AI449000 anticorps
  • CAG-16 anticorps
  • cagh44 anticorps
  • D0Kist7 anticorps
  • foxP anticorps
  • Foxp2 anticorps
  • foxp2a anticorps
  • foxP2b anticorps
  • RGD1559697 anticorps
  • spch1 anticorps
  • tnrc10 anticorps
  • xlFoxP2 anticorps

Protein level used designations for anti-Forkhead Box P2 (FOXP2) Anticorps

CAG repeat protein 44 , forkhead box protein P2 , forkhead/winged-helix transcription factor , trinucleotide repeat containing 10 , trinucleotide repeat-containing gene 10 protein , forkhead box P2 , transcription factor FoxP2 , forkhead box P protein , lmw-gs , forkhead box transcription factor , xlFoxP2

93986 Homo sapiens
114142 Mus musculus
449627 Pan troglodytes
482413 Canis lupus familiaris
500037 Rattus norvegicus
505502 Bos taurus
555242 Danio rerio
613237 Macaca mulatta
751769 Taeniopygia guttata
769935 Gallus gallus
100101742 Xenopus (Silurana) tropicalis
100127352 Sus scrofa
100134847 Felis catus
100137387 Papio anubis
100144325 Oryctolagus cuniculus
100169841 Oryzias latipes
100303474 Saccoglossus kowalevskii
542882 Triticum aestivum
779033 Xenopus laevis
100439724 Pongo abelii
734154 Xenopus laevis
100990292 Pan paniscus
100717297 Cavia porcellus
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