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The protein encoded by FXR2 is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. De plus, nous expédions Fragile X Mental Retardation, Autosomal Homolog 2 Protéines (3) et et beaucoup plus de produits pour cette protéine.
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Human Monoclonal FXR2 Primary Antibody pour ICC, IF - ABIN108611
Zhang, OConnor, Siomi, Srinivasan, Dutra, Nussbaum, Dreyfuss: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. dans The EMBO journal 1996
Cow (Bovine) Polyclonal FXR2 Primary Antibody pour WB - ABIN2778916
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... dans Molecular systems biology 2007
Human Monoclonal FXR2 Primary Antibody pour ICC, IF - ABIN152598
Darnell, Fraser, Mostovetsky, Darnell: Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. dans Human molecular genetics 2009
Inhibition of the remaining family member FXR1 selectively blocks cell proliferation in human cancer cells containing homozygous deletion of both TP53 and FXR2 in a collateral lethality manner.
An accumulation of 8 SNPs in the fragile gene family (FMR1, FXR1 and FXR2)were found associated with autistic traits in a sample of male patients.
Data show that the nuclear localization signals of the FXR1 and FXR2 comprise tandem Tudor domain architectures.
These results indicate that FMR1 gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.
FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.
We discovered that FXR1P-deficient aNSCs have altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a, p21) as a direct target of FXR1P.
Both Fmr1 and Fxr2 knockout mice have reduced fat deposits and glucose metabolism.
these findings show a coordinated regulation of PSD95/Dlg4 mRNA by FMRP and FXR2P that ultimately affects its fine-tuning during synaptic activity.
Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.
This protein shows high expression in brain and testis. The protein was tested in a behavioral test battery in knockout mice. The mice showed behavioral abnormalities.
Findings suggest that Fmr1 and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes.
Fxr2 regulates mammalian circadian behavioral rhythms.
to unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice; genes and gene groups de-regulated in the brains of Fxr2 knockout mice were identified
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.
fragile X mental retardation syndrome-related protein 2
, fragile X mental retardation syndrome related protein 2
, fragile X mental retardation, autosomal homolog 2
, fragile X mental retardation syndrome-related protein 2-like
, fragile X-mental retardation 1-like 2
, fragile X mental retardation gene 2, autosomal homolog
, fragile X mental retardation-related protein 2