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The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. De plus, nous expédions FRAT2 Kits (4) et FRAT2 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FRAT2 Primary Antibody pour ELISA, WB - ABIN249481
Saitoh, Moriwaki, Koike, Takagi, Miwa, Shiokawa, Katoh: Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. dans Biochemical and biophysical research communications 2001
Data show that MLL fusion oncogenes maintain leukemia-associated Rac GTPases activity by regulating Frat gene expression, specifically Frat2.
Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.
FRAT-2 enhances glycogen synthase kinase 3 beta-mediated phosphorylation of a primed substrate to a greater extent than an unprimed substrate
It suggests that activation of GSK-3 inhibits PP-2A through up-regulation of I(2)(PP-2A) with hnRNP A18-involved mechanism.
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.
GSK-3 binding protein FRAT2
, frequently rearranged in advanced T-cell lymphomas 2
, GSK-3-binding protein FRAT2