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Proton-sensing receptor involved in pH homeostasis. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Mouse (Murine) Polyclonal GPR68 Primary Antibody pour WB - ABIN1881516
Singh, Berk, Oates, Zhao, Tan, Jiang, Zhou, Kirmani, Steinmetz, Lindner, Xu: Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. dans Journal of the National Cancer Institute 2007
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Human Polyclonal GPR68 Primary Antibody pour IHC (p) - ABIN2475955
Mogi, Tomura, Tobo, Wang, Damirin, Kon, Komachi, Hashimoto, Sato, Okajima: Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. dans Journal of pharmacological sciences 2005
Cow (Bovine) Polyclonal GPR68 Primary Antibody pour ICC, IF - ABIN1048863
Komarova, Pereverzev, Shum, Sims, Dixon: Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. dans Proceedings of the National Academy of Sciences of the United States of America 2005
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Our results suggest that OGR1-dependent increases in TRPC4 (Montrer TRPC4 Anticorps) expression may favour formation of highly Ca(2 (Montrer CA2 Anticorps)+) -permeable TRPC4 (Montrer TRPC4 Anticorps)-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 (Montrer TRPC4 Anticorps) in progression of certain types of medullablastoma.
Blocking of GPR68 or NF-small ka, CyrillicB activity severely attenuated acidification induced IL-8 (Montrer IL8 Anticorps) production.
These results suggest that zOGR1, but not GPR4 (Montrer GPR4 Anticorps), is also a metal-sensing G-protein-coupled receptor (Montrer ADRA1A Anticorps) in addition to a proton-sensing G-protein-coupled receptor (Montrer ADRA1A Anticorps), although not all metals that activate hOGR1 activated zOGR1.
data identify a role for GPR68 as a proton sensor that is required for proper enamel formation
coexpression of OGR1- and G2A (Montrer GPR132 Anticorps)-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A (Montrer GPR132 Anticorps). The oligomeric potential locates receptors at a specific site, which leads to enhanced
Proton-sensing GPCR (Montrer NMUR1 Anticorps)-YAP (Montrer YAP1 Anticorps) Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells
The deconstruction of OGR1-dependent signaling may aid our understanding of mucosal inflammation mechanisms
Provide evidence for the roles of OGR1 and ASIC1a (Montrer ACCN2 Anticorps) in the regulation of intestinal passive Mg(2 (Montrer MUC7 Anticorps)+) absorption.
the expression of OGR1 in myeloid-derived cells, especially in double positive cells, was required for prostate tumor cell-induced immunosuppression.
The involvement of ovarian cancer G-protein-coupled receptor 1 in acidic extracellular environment may be an underlying mechanism responsible for bone pain in osteoporosis or bone metastasis without clinically proved fractures.
In rapidly growing mice, lack of OGR1 leads to increased bone mass with increased bone turnover and a greater increase in bone formation than resorption.
Here, we demonstrate that metals, Fe, Zn, Co, Ni and Mn are the novel OGR1 agonists, which can singly activate OGR1 in neutral pH.
CaSR (Montrer CASR Anticorps) and OGR1 reciprocally inhibit signaling through each other in central neurons, and that this is lost in their transformed counterparts. Acidification potentiates OGR1.
acidic pH stimulates cGMP accumulation preferentially through the OGR1/Gq/11 proteins/phospholipase C (Montrer PLC Anticorps)/Ca(2 (Montrer CA2 Anticorps)+)/nNOS (Montrer NOS1 Anticorps) in N1E-115 neuronal cells. Akt (Montrer AKT1 Anticorps)-mediated phosphorylation of nNOS (Montrer NOS1 Anticorps)
OGR1 on dendritic cells is critical for their migration to draining lymph nodes, which, in turn, stimulates Th2 phenotype change and subsequent induction of airway inflammation and hyperreactivity.
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin (Montrer INS Anticorps) secretion.
OGR1 alters the pH-sensitive response of NHE and H+-ATPase (Montrer ATP6AP1 Anticorps) activity in proximal tubules.
regulator of G-protein signaling 18 (Montrer RGS18 Anticorps) acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT (Montrer NFATC1 Anticorps) signaling pathway
OGR1 induces an increase in Ca(i (Montrer CA1 Anticorps)) in response to acidic medium and is a prime candidate for an osteoblast proton sensor.
OGR1's role in osteoclastogenesis is not strong enough to affect overall bone development.
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity).
G protein-coupled receptor 68
, ovarian cancer G-protein coupled receptor 1-like
, G-protein coupled receptor 68
, ovarian cancer G protein-coupled receptor, 1
, ovarian cancer G-protein coupled receptor 1
, sphingosylphosphorylcholine receptor
, g protein-coupled receptor RGR1