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Study designed and synthesized a series of 2-PCCA analogues bearing a variety of substituents at the phenyl ring of the aniline moiety to determine the structure-activity relationship (SAR) in this region; SAR studies suggested that there is a hydrophobic pocket in the GPR88 binding site interacting with the aniline region of 2-PCCA
GPR88 in A2A receptor-expressing neurons modulates psychomotor behavior but not sensorimotor gating.
GPR88 activity shapes the mouse brain functional and structural connectome
Analysis of Gpr88-adenosine A2AR-Cre transgenic mice shows that GPR88 in adenosine A2AR medium spiny neurons regulates locomotor and anxiety behaviors.
GPR88 expression in the corpus striatum is necessary to efficiently integrate effort and choice behavior.
Results demonstrate that GPR88 is implicated in a large repertoire of behavioral responses that engage motor activity, spatial learning, and emotional processing, reveal functional antagonism between GPR88 and delta opioid receptor activities in vivo
This study demonistrated that lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders.
G protein-coupled receptor 88
, G protein coupled receptor 88
, G-protein coupled receptor 88
, probable G-protein coupled receptor 88
, striatum-specific G-protein coupled receptor