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GINS3 encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes.
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Psf3 expression was strongly correlated with tumor progression in non-small-cell lung cancer
Two downregulated genes, NDRG4 (Montrer NDRG4 Anticorps) and GINS3, have been located in a genomic interval associated with cardiac repolarization in published GWASs and zebra fish knockout models
PSF3 expression plays an important role in the progression of colorectal cancer and acts as a factor significantly affecting the prognosis of patients.
These results suggest that PSF3 is a potential biomarker for diagnosis of progression in colon cancer and could
expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha (Montrer ESR1 Anticorps), and PSF3 acts as a gene responsive to transcription factor E2F1 (Montrer E2F1 Anticorps)
This sensitized zebrafish screen identified 15 novel myocardial repolarization genes. Among these genes is GINS3, the human ortholog of which is a major locus in 2 concurrent human genome-wide association studies of QT interval.
This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described.
DNA replication complex GINS protein PSF3
, potential GINS DNA replication initiation complex subunit