anti-Germ Cell Associated 2 (Haspin) (GSG2) Anticorps

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. De plus, nous expédions Germ Cell Associated 2 (Haspin) Protéines (7) et Germ Cell Associated 2 (Haspin) Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GSG2 83903 Q8TF76
GSG2 687827  
GSG2 14841 Q9Z0R0
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Top anti-Germ Cell Associated 2 (Haspin) Anticorps sur anticorps-enligne.fr

Showing 10 out of 53 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-GSG2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: 721_B cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Chien Lapin Inconjugué WB WB Suggested Anti-GSG2 Antibody Titration: 1.0 ug/ml Positive Control: Placenta 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Chien Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis GSG2 using Jurkat whole cell lysates 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: GSG2 Antibody [NBP1-26626] - Human prostate carcinoma. Antibody used at a dilution of 1:200. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$559.35
Détails
Humain Lapin Inconjugué IHC (p), WB Western Blot at 1:1000 dilution Lane 1: human testis lysate Lane 2: Daudi whole cell lysate Lysates/proteins at 20 ug per lane. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué IHC (p), WB Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line lysates (35 µg/lane). This demonstrates the Haspin antibody detected the Haspin protein (arrow). Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line lysates (35 µg/lane). This demonstrates the Haspin antibody detected the Haspin protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué WB Western Blot: GSG2 Antibody [NBP1-79836] - Titration: 0.2-1 ug/ml, Positive Control: 721_B cell lysate. 100 μL Connectez-vous pour afficher 8 to 11 Days
$488.73
Détails
Humain Souris Inconjugué WB Western Blot analysis of GSG2 expression in transfected 293T cell line by GSG2 MaxPab polyclonal antibody.Lane 1: GSG2 transfected lysate(88.50 KDa).Lane 2: Non-transfected lysate. 50 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails

anti-Germ Cell Associated 2 (Haspin) Anticorps mieux référencés

  1. Human Polyclonal GSG2 Primary Antibody pour IHC (p), WB - ABIN1882168 : Dai, Sultan, Taylor, Higgins: The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. dans Genes & development 2005 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal GSG2 Primary Antibody pour WB - ABIN949715 : Wang, Wei, Du, Cao, Zhang, Liu, Liu, Chen, Ma: H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis. dans Cell cycle (Georgetown, Tex.) 2016 (PubMed)

Plus d’anticorps contre Germ Cell Associated 2 (Haspin) partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. These data provide insight into how Hasp and Hig construct the synaptic cleft matrix and regulate the differentiation of cholinergic synapses, and also illuminate a previously unidentified architecture within synaptic clefts

Human Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B.

  2. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved.

  3. Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP

  4. This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors

  5. Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool.

  6. Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.

  7. Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling

  8. Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis

  9. findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells

  10. phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B during mitosis

  11. Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.

  12. Haspin is a relatively newly discovered kinase that phosphorylates histone H3 during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW]

  13. This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis

  14. Haspin is required to maintain centromeric cohesion during mitosis.

Mouse (Murine) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.

  2. Data implicate haspin as a regulator of the chromosomal passenger complex and chromosome segregation during meiosis I.

  3. the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation-dependent manner; Gsg2 is under epigenetic control

  4. the 193-bp DNA sequence in Haspin promotor is sufficient for the specific, bidirectional, and synchronous expression in germ cells in the testis.

Germ Cell Associated 2 (Haspin) (GSG2) profil antigène

Profil protéine

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity).

Gene names and symbols associated with GSG2

  • putative serine/threonine-protein kinase haspin homolog (LOC552287) anticorps
  • histone H3 associated protein kinase (HASPIN) anticorps
  • CG40080 gene product from transcript CG40080-RA (Haspin) anticorps
  • uncharacterized LOC100122327 (LOC100122327) anticorps
  • histone H3 associated protein kinase (Haspin) anticorps
  • BcDNA:LD07633 anticorps
  • CG40080 anticorps
  • Dmel\\CG40080 anticorps
  • Haspin anticorps
  • NV16901 anticorps

Protein level used designations for GSG2

serine/threonine-protein kinase haspin-like protein , germ cell associated 2 (haspin) , haspin , CG40080-PA , Haspin-PA , putative serine/threonine-protein kinase haspin homolog , H-haspin , germ cell-specific gene 2 protein , haploid germ cell-specific nuclear protein kinase , serine/threonine-protein kinase haspin

GENE ID SPECIES
552287 Apis mellifera
748101 Pan troglodytes
3355064 Drosophila melanogaster
100122327 Nasonia vitripennis
83903 Homo sapiens
767819 Bos taurus
687827 Rattus norvegicus
14841 Mus musculus
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