anti-Gigaxonin (GAN) Anticorps

GAN encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. De plus, nous expédions GAN Kits (9) et GAN Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GAN 209239 Q8CA72
GAN 307893  
GAN 8139 Q9H2C0
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Showing 10 out of 40 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-GAN Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: THP-1 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué IP Immunoprecipitation: Gigaxonin Antibody [NBP1-49924] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Gigaxonin antibody NBP1-49924 used for IP at 3 ug/mg lysate. Gigaxonin was also immunoprecipitated by rabbit anti-Gigaxonin antibody NBP1-49923, which recognizes an upstream epitope. For blotting immunoprecipitated Gigaxonin, NBP1-49924 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds. 100 μL Connectez-vous pour afficher 7 to 9 Days
Humain Lapin Inconjugué WB Western blot analysis of extract of SW480 and mouse skeletal muscle cells, using GAN antibody. 100 μL Connectez-vous pour afficher 16 Days
Roussette (Chauve-souris) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
Humain Lapin Inconjugué IHC, IHC (p) Immunohistochemistry: Gigaxonin Antibody [NBP2-33569] - Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells. Immunocytochemistry/Immunofluorescence: Gigaxonin Antibody  - Immunofluorescent staining of human cell line RT4 shows localization to microtubules. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
Humain Lapin Inconjugué ICC, IHC, IP, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Connectez-vous pour afficher 13 to 16 Days
Humain Lapin Inconjugué WB GAN antibody used at 1 ug/ml to detect target protein. 50 μg Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué WB Western Blot: Gigaxonin Antibody [NBP1-57821] - THP-1 cell lysate, concentration 0.2-1 ug/ml. 100 μL Connectez-vous pour afficher 8 to 11 Days
Humain Lapin Inconjugué IF (p), IHC (p) Paraformaldehyde-fixed, paraffin embedded rat brain, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with Gigaxonin Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Connectez-vous pour afficher 3 to 7 Days
Humain Souris Inconjugué IF, ELISA, WB Detection limit for recombinant GST tagged GAN is approximately 3ng/ml as a capture antibody. Western Blot detection against Immunogen (32.78 KDa) . 100 μg Connectez-vous pour afficher 11 to 12 Days

GAN Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Mouse (Murine) , , ,

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Rat (Rattus) , , ,

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Human , , ,
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anti-GAN Anticorps mieux référencés

  1. Human Polyclonal GAN Primary Antibody pour IP - ABIN4314110 : Johnson-Kerner, Garcia Diaz, Ekins, Wichterle: Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. dans PLoS ONE 2015 (PubMed)

Plus d’anticorps contre GAN partenaires d’interaction

Mouse (Murine) Gigaxonin (GAN) interaction partners

  1. We demonstrate that gigaxonin is crucial for ubiquitin-proteasomal degradation of neuronal Intermediate filaments. Moreover,Intermediate filaments accumulation impairs mitochondrial motility and is associated with metabolic and oxidative stress

  2. gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments

  3. GAN variants are identified in brain sections of mutant mice with giant axonal neuropathy.

  4. results identify gigaxonin as a ubiquitin scaffolding protein that controls MAP1B (Montrer MAP1B Anticorps)-LC degradation, and provide insight into the molecular mechanisms underlying human neurodegenerative disorders

  5. Disruption of gigaxonin results in an impaired ubiquitin-proteasome system leading to a substantial accumulation of toxic microtubule-associated protein (Montrer SPAG5 Anticorps) MAP8 (Montrer MAP1S Anticorps) in the null mutants.

  6. At 6 months of age the Gigaxonin-knockout(Deltaexon1;Deltaexon1) mice exhibit a modest hind limb muscle atrophy, a 10% decrease of muscle innervation and a 27% axonal loss in the L5 ventral roots.

Human Gigaxonin (GAN) interaction partners

  1. Our protocol showed high specificity and sensitivity for homozygosity detection and facilitated the identification of novel mutations in GAN, GBA2 (Montrer GBA2 Anticorps), and ZFYVE26 (Montrer ZFYVE26 Anticorps) in four families affected by hereditary spastic paraplegia or Charcot-Marie-Tooth disease

  2. We believe that molecular and functional investigation of gigaxonin mutations including the exon 8 polymorphism could lead to an improved understanding of the relationship between GAN and cancer

  3. A novel sequence alteration in the gene GAN, c.103G > T, was identified as most likely the underlying cause for a sensory-motor axonal neuropathy in a large consanguineous family presenting as Charcot-Marie-Tooth disease type 2.

  4. The disease is caused by GAN gene mutations on chromosome 16q24.1. To determine clinical and genetic results in Turkish patients with GAN.

  5. This study showed that The instability of Gigaxonin causes Giant Axonal Neuropathy.

  6. A novel missense mutation in four siblings born to consanguineous parents of Arab origin with clinical and molecular features compatible with giant axonal neuropathy.

  7. gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments

  8. No GAN variant is identified in DNA obtained from well-characterized cases of human neuronal intermediate filament inclusion disease (frontotemporal dementia).

  9. Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.

  10. Ubiquitin-proteasome system shown to be responsible for neurodegeneration occurring in GAN-null neurons and plays crucial roles in cytoskeletal functions and dynamics.

GAN profil antigène

Profil protéine

This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).

Gene names and symbols associated with anti-Gigaxonin (GAN) Anticorps

  • gigaxonin L homeolog (gan.L) anticorps
  • gigaxonin (gan) anticorps
  • gigaxonin (GAN) anticorps
  • giant axonal neuropathy (Gan) anticorps
  • gigaxonin (Gan) anticorps
  • A330045G18 anticorps
  • GAN anticorps
  • GAN1 anticorps
  • gigaxonin anticorps
  • KLHL16 anticorps
  • MGC81691 anticorps

Protein level used designations for anti-Gigaxonin (GAN) Anticorps

gigaxonin , giant axonal neuropathy , giant axonal neuropathy (gigaxonin) , kelch-like family member 16 , kelch-like protein 16

447405 Xenopus laevis
549284 Xenopus (Silurana) tropicalis
713996 Macaca mulatta
100027517 Monodelphis domestica
100339638 Oryctolagus cuniculus
100388790 Callithrix jacchus
100453030 Pongo abelii
100484003 Ailuropoda melanoleuca
100549375 Meleagris gallopavo
100586857 Nomascus leucogenys
430553 Gallus gallus
468044 Pan troglodytes
489694 Canis lupus familiaris
100069891 Equus caballus
209239 Mus musculus
307893 Rattus norvegicus
8139 Homo sapiens
100518489 Sus scrofa
521175 Bos taurus
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