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The protein encoded by GRPP is actually a preproprotein that is cleaved into four distinct mature peptides.
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Everolimus down-regulates the systemic levels of gastrin (Montrer GAST Anticorps) and glucagon (Montrer GCG Anticorps) in patients with pancreatic neuroendocrine tumors.
Glucagon (Montrer GCG Anticorps)-like peptide (GLP-2 (Montrer GCG Anticorps)) stimulates cancer myofibroblast proliferation, migration and invasion; GLP-2 (Montrer GCG Anticorps) acts indirectly on epithelial cells partly via increased Insulin (Montrer INS Anticorps)-like growth factor (IGF) expression in myofibroblasts.
Describe model, in which the release of GIP (Montrer GIP Anticorps)/GLP-1 (Montrer GCG Anticorps) is stimulated by glucose in the proximal small intestine, and no differences in the secretion dynamics between healthy individuals and patients with T2D are identified after taking differences in glucose profiles into account.
the solvent exposure of the two Phe sites along the glucagon (Montrer GCG Anticorps) sequence was determined, showing that 4F-Phe6 was fully solvent exposed and 4F-Phe22 was only partially exposed
Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 (Montrer GCG Anticorps) levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 (Montrer GCG Anticorps) = glucagon-like peptide 1 (Montrer GCG Anticorps))
GLP-2 could be considered an hormone causing positive energy balance, which, however has the role to mitigate the metabolic dysfunctions associated with hyper-adiposity. [review]
Studies indicate that nutrient-induced glucagonlike peptide-1 (GLP-1 (Montrer GCG Anticorps)) response was one of the best predictors of type 2 diabetes mellitus (T2DM) remission after Roux-en-Y-gastric-bypass (RYGB).
Insulin (Montrer INS Anticorps) resistance in non-diabetic individuals is associated with raised fasting GLP-1 (Montrer GCG Anticorps) levels but reduced GLP-1 (Montrer GCG Anticorps) responses to meal stimulation.
we saw that GLP-1 (Montrer GCG Anticorps) induces phosphorylation of the epidermal growth factor receptor (Montrer EGFR Anticorps) and activation of Foxo1 (Montrer FOXO1 Anticorps), resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1 (Montrer GCG Anticorps)-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase (Montrer AMY Anticorps) and lipase (Montrer LIPG Anticorps) levels in subjects treated with GLP-1 receptor (Montrer GLP1R Anticorps) agonists reflect adaptive growth rather than early-stage pancreatitis.
Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Glucokinase (Montrer GCK Anticorps) governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon (Montrer GCG Anticorps) secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
in colonic crypt cultures, the GLP-1 (Montrer GCG Anticorps) secretion induced by such Gq + Gs GPR40 (Montrer FFAR1 Anticorps) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
Enteric GLP-1 (Montrer GCG Anticorps) activates NO production by enteric neurons that is impaired in type 2 diabetes. Gut (Montrer GUSB Anticorps) microbiota dysbiosis induces enteric neuropathy. Gut (Montrer GUSB Anticorps) microbiota dysbiosis is responsible for the GLP-1 (Montrer GCG Anticorps) resistance.
of glucagon-like peptide-1 (Montrer GCG Anticorps) in vagotomized mice may prevent VLDL overproduction and insulin (Montrer INS Anticorps) resistance induced by high-fat diet.
beta-cell function, plasma active GLP-1 (Montrer GCG Anticorps) levels, the GLP-1R (Montrer GLP1R Anticorps) pathway in beta cells and L cell differentiation, were investigated.
CCK (Montrer CCK Anticorps)/GLP-1 (Montrer GCG Anticorps) play contributory roles in anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol.
The role of syntaxin 1A (Montrer STX1A Anticorps) in GLP1 (Montrer GCG Anticorps) release from intestinal cells as a response to external stimuli is reported.
GCG (Montrer GCG Anticorps) neurons likely stimulate separate populations of downstream cells to produce a change in food intake and glucose homeostasis and that these effects depend on the metabolic state of the animal.
Together, our data indicate effects of AgoPAMs that go beyond glucose lowering previously observed with GPR40 (Montrer FFAR1 Anticorps) partial agonist treatment with additional potential for weight loss.
pancreatic reactivation of Gcg (Montrer GCG Anticorps) fully restored the effect of exendin-[9-39] to impair both oral and intraperitoneal glucose tolerance.
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I