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Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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sphingosine, the cytotoxic metabolite accumulating in Gaucher cells through the action of GBA2, directly binds to GBA2 and inhibits its activity.
GBA2 is particularly abundant in Purkinje cells (PCs), one of the most affected neuronal populations in NPC (Montrer NPC1 Kits ELISA) disease.
glucosylceramide accumulation in GBA2 knockout-mice alters cytoskeletal dynamics due to a more ordered lipid organization in the plasma membrane. Similar cytoskeletal defects were observed in male germ and Sertoli cells from GBA2 knockout-mice.
the deletion of Gba2 significantly rescues the type 1 Gaucher disease clinical phenotype.
redefine GBA2 activity as the beta-glucosidase that is sensitive to inhibition by N-butyldeoxygalactonojirimycin.
GBA2 is localized at the ER and Golgi, which puts GBA2 in a key position for a lysosome-independent route of glucosylceramide-dependent signaling.
The repression of IL-6 (Montrer IL6 Kits ELISA)/STAT3 (Montrer STAT3 Kits ELISA) signalling pathway seems to be one of the mechanisms for the delay of liver regeneration in GBA2-deficient mice.
GBA1 (Montrer GBA Kits ELISA) and GBA2 activities had characteristic differences between the studied fibroblast, liver and brain samples.
The coiled-coil structure of LIMP-2 (Montrer SCARB2 Kits ELISA) is required for its interaction with beta-glucocerebrosidase (Montrer GBA Kits ELISA).
L-type calcium channel blockers have the ex vivo effects of increasing GCase (Montrer GBA Kits ELISA) activity and protein in mouse fibroblasts
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo.
, beta-glucocerebrosidase 2
, beta-glucosidase 2
, bile acid
, glucosidase, beta (bile acid) 2
, glucosylceramidase 2
, non-lysosomal glucosylceramidase
, bile acid beta-glucosidase