anti-Glutamate Dehydrogenase (GDHB) Anticorps

GDHB encodes glutamate dehydrogenase protein\; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. De plus, nous expédions et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
Anti-Humain GDHB GDHB 2746 P00367
Anti-Souris GDHB GDHB 14661 P26443
Anti-Rat GDHB GDHB 24399 P10860
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Clostridium Souris Inconjugué ELISA, IF, LFCIA   1 mg 11 to 12 Days
$460.00
Détails

Plus d’anticorps contre Glutamate Dehydrogenase partenaires d’interaction

Human Glutamate Dehydrogenase (GDHB) interaction partners

  1. We provide comprehensive data indicating GLUD1 plays an important role in luminal/ER + breast cancer

  2. Both GDH1 and GDH2 were overexpressed in the HEK293 cell line and found to be co-localized in subcellular fractions.

  3. GLUD1 may play an important role in osteogenic differentiation of human dental pulp stem cells

  4. This study provides insight into the molecular mechanism by which GDH1-mediated metabolic reprogramming of glutaminolysis mediates lung cancer metastasis and offers a therapeutic strategy for patients with LKB1-deficient lung cancer.

  5. Phenotypic heterogeneity of GDH-hyperinsulinemia patients was observed within the Chinese cohort in the present study. The fact that most patients had a GLUD1 p. S445L mutation implies that this site could be a hotspot in Chinese patients.

  6. structural model of a complex of human Sirt4 and GDH in order to elucidate the molecular mechanism underlying the ADP-ribosylation of GDH by Sirt4

  7. Upregulation of GLUD1 and SLC25A13 was associated with tumor aggressiveness and poorer prognosis in colorectal cancer patients.

  8. This study showed that SIRT5 supports the anaplerotic entry of glutamine into the TCA cycle in malignant phenotypes of CRC via activating GLUD1.

  9. the present study shows that the GDHS445L enzyme is highly sensitive to the allosteric activator ADP, explaining the hyperactivity of this mutant. INS-1E beta-cells expressing GDHS445L responded to glutamine stimulation by increasing the mitochondrial respiration and ATP production, as well as by a rise in cytosolic calcium.

  10. We have shown that alpha-ketoglutarate substrate inhibition kinetics of GDH, which include both random and obligatory ordered association/dissociation reactions, robustly control the ratio between glutamate and ammonium under a wide range of intracellular substrate variation. Dysregulation of this activity under pericentral nitrogen insufficiency contributes to the breaking down of ammonia homeostasis and thereby can s...

  11. mRNA and protein levels of GluD1 were increased in iPSC-derived neurons from FOXG1(+/-) patients.

  12. Hypoxia-induced expression of GDH relies on the up-regulation of HIF1alpha but not HIF2alpha. HIF1alpha binds the promoter of GDH and promotes the transcription of GDH gene in lung cancer cells.

  13. Results indicate that it is possible to use high-throughput screening methods to find activators for glutamate dehydrogenase (GDH) that might be useful as pharmaceutical agents.

  14. Missense mutation of GLUD1 is associated with Hyperinsulinism-hyperammonemia syndrome.

  15. Analysis of Serbian patients with Hyperinsulinism/hyperammonemia syndrome confirms the association of p.S445L and p.R221C mutations with hypoglycaemic seizures noted within the first three months of life and with subsequent risk for cognitive impairment and/or epilepsy.

  16. GLUD1 is differentially expressed in the cellular and subcellular compartments of numerous tissues.

  17. GLUD1 mutation is associated with congenital hyperinsulinism-hyperammonemia.

  18. Study of the expression of the GDH1/2 in human steroidogenic organs revealed that, while GDH2 was expressed specifically in steroid-synthesizing cells, GDH1 was expressed both in the cells that produce steroids and in those that lack endocrine function.

  19. GDH plays a critical role in colorectal cancer progression

  20. Mutation in the GLUD1 gene is associated with hyperinsulinism/hyperammonemia.

Mouse (Murine) Glutamate Dehydrogenase (GDHB) interaction partners

  1. we show that GDH is a crucial enzyme for neurons to metabolize glutamine-derived carbon in the tricarboxylic acid cycle during glucose deprivation

  2. Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.

  3. Data suggest that metabolism of glutamine and related analogs by Gdh in intestinal L-cells explains why Glp1 secretion, but not that of insulin by pancreatic beta-cells, is activated by these secretagogues. (Gdh = glutamate dehydrogenase; Glp1 = glucagon-like peptide 1)

  4. mRNA and protein levels of GluD1 were increased in fetal brain of foxg1(+/-) mice. mRNA and protein levels of GluD1 were decreased in adult brain of foxg1(+/-) mice.

  5. lack of glutamate oxidation in brain-specific GDH null CnsGlud1-/- mice resulted in a central energy-deprivation state with increased ADP/ATP ratios and phospho-AMPK in the hypothalamus.

  6. This study demonstrated a critical requirement for GluD1 in normal spine development in the cortex and hippocampus.

  7. The GDH activity in mice is highest in the liver with NAD(+) as a coenzyme and highest GDH activity was determined at a glutamate concentration of 10 mM.

  8. Age-related increases of glutamate were observed only in the striatum of the glutamate dehydrogenase 1 mice

  9. Glutamate hyperactivity caused gene expression changes in the hippocampus at all ages

  10. GluD1 regulates the connectivity of parallel fiber-interneuron synapses and promotes differentiation of interneurons.

  11. The GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator.

  12. GluD1 is crucial for normal functioning of synapses and absence of GluD1 leads to specific abnormalities in learning and memory.

  13. Permissive levels of glutamate are required for the full development of glucose-stimulated insulin secretion and glutamate dehydrogenase plays an indispensable role in this process.

  14. Mice deficient in Glud1 exhibit deficient oxidative catabolism of glutamate in astrocytes, showing that GDH is required for Krebs cycle pathway; however, lack of GDH modifies metabolic handling of glutamate without altering synaptic transmission.

  15. These results suggest that GluD1 might contribute to the formation of specific synapses in the hippocampus such as those formed by the projecting neurons of the entorhinal cortex.

  16. Data show that Balb/c Glud1 transgenic mice had significantly increased depolarization-induced glutamate release compared with wild type littermates.

  17. In betaGlud1(-/-) mice, the reduced secretory capacity resulted in lower plasma insulin levels in response to both feeding and glucose load, while body weight gain was preserved

Glutamate Dehydrogenase (GDHB) profil antigène

Profil protéine

This gene encodes glutamate dehydrogenase protein\; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.

Gene names and symbols associated with GDHB

  • glutamate dehydrogenase 1 (GLUD1) anticorps
  • glutamate dehydrogenase 1 (Glud1) anticorps
  • Ac2-281 anticorps
  • AI118167 anticorps
  • GDH anticorps
  • Gdh-X anticorps
  • GDH 1 anticorps
  • Gdh1 anticorps
  • Glud anticorps
  • Gludeha anticorps
  • Gludl anticorps
  • MRG-2 anticorps

Protein level used designations for GDHB

glutamate dehydrogenase 1, mitochondrial , GDH 1 , glutamate dehydrogenase (NAD(P)+) , memory-related gene 2 protein

GENE ID SPECIES
423612 Gallus gallus
2746 Homo sapiens
14661 Mus musculus
24399 Rattus norvegicus
100684847 Canis lupus familiaris
100157162 Sus scrofa
100351029 Oryctolagus cuniculus
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