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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. De plus, nous expédions GCLM Kits (48) et GCLM Protéines (13) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 86 products:
Human Monoclonal GCLM Primary Antibody pour ELISA, WB - ABIN516058
Balamurugan, Akhov, Selvaraj, Pugazhenthi: Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. dans Pancreas 2009
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Cow (Bovine) Polyclonal GCLM Primary Antibody pour IHC, WB - ABIN2785805
Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. dans International archives of occupational and environmental health 2008
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Human Polyclonal GCLM Primary Antibody pour ELISA, IHC - ABIN6261915
Zou, Wang, Peng, Wei: Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells. dans Oxidative medicine and cellular longevity 2017
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Human Polyclonal GCLM Primary Antibody pour ICC, IF - ABIN443275
Lu, Samanta, Xiang, Zhang, Hu, Chen, Bullen, Semenza: Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. dans Proceedings of the National Academy of Sciences of the United States of America 2015
Human Polyclonal GCLM Primary Antibody pour FACS, IF - ABIN653046
Moyer, Sun, Batzler, Li, Schaid, Yang, Weinshilboum: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. dans Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010
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Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 (Montrer GLI2 Anticorps) macrophages is tightly and differentially regulated via GCLC (Montrer GCLC Anticorps) and GCLM subunits of glutamate cysteine ligase (Montrer GCLC Anticorps).
Two promoter polymorphisms of GCLM (-588C/T) and GCLC (Montrer GCLC Anticorps) (-128T/C) are associated with an increased risk of ischemic heart disease in Kazakhstan population.
High GCLM expression is associated with chemotherapy resistance in breast cancer.
Glutaminolysis is activated in ES2 (Montrer DGCR14 Anticorps) and OVCAR3, though ES2 (Montrer DGCR14 Anticorps) exclusively synthesizes amino acids and GSH. ES2 (Montrer DGCR14 Anticorps) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (Montrer DGCR14 Anticorps) to carboplatin. HNF1beta (Montrer HNF1B Anticorps) regulates the expression of GCLC (Montrer GCLC Anticorps), but not GCLM, and consequently GSH production in ES2 (Montrer DGCR14 Anticorps)
Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (Montrer HMOX1 Anticorps)) and GCLM via activation of NRF2 (Montrer GABPA Anticorps)-ARE (nuclear factor erythroid 2-antioxidant response element) signaling.
miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.
Data suggest expression of hepatocyte GCLC (Montrer GCLC Anticorps) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (Montrer GCLC Anticorps) and GCLM expression.
miR (Montrer MLXIP Anticorps)-320a has a role in modulating the induction of HO-1 (Montrer HMOX1 Anticorps), GCLM and OKL38 (Montrer OSGIN1 Anticorps) by oxidized phospholipids in endothelial cells
This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (Montrer GCLC Anticorps).
Knockdown of glutamate cysteine ligase catalytic subunit (Montrer GCLC Anticorps) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.
glutathione levels in the skin of Gclm knock-out mice are reduced by 70 %, which is sufficient for wound repair in young mice, but become rate-limiting upon aging
Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.
Upregulation of both GCLC (Montrer GCLC Anticorps) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.
In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (Montrer PVALB Anticorps) interneurons and have long-term consequences.
Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (Montrer PHB2 Anticorps).
The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.
Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.
Clinically relevant levels of TGF-beta1 (Montrer TGFB1 Anticorps) suppresses GCLC (Montrer GCLC Anticorps) and GCLM expression in mouse lung.
Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.
Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.
glutamate-cysteine ligase regulatory subunit
, GCS light chain
, gamma-ECS regulatory subunit
, gamma-glutamylcysteine synthetase regulatory subunit
, glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
, glutamate--cysteine ligase regulatory subunit
, glutamate-cysteine ligase modifier subunit
, GSC light chain
, glutamate--cysteine ligase modifier subunit
, glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
, glutamate-cysteine ligase modifier subunit delta2 alternative splicing
, glutamate-cysteine ligase regulatory protein