anti-Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) Anticorps

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. De plus, nous expédions GCLM Kits (48) et GCLM Protéines (13) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GCLM 29739 P48508
GCLM 2730 P48507
GCLM 14630 O09172
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Top anti-GCLM Anticorps sur anticorps-enligne.fr

Showing 10 out of 86 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué FACS, IF, IHC (p), WB Western blot analysis of GCLM Antibody (C-term) (ABIN653046) in 293 cell line and mouse kidney tissue lysates (35 µg/lane). GCLM (arrow) was detected using the purified polyclonal antibody. GCLM Antibody (C-term)(ABIN653046) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Immunohistochemical analysis of GCLM staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of GCLM expression in SHSY5Y (A), HeLa (B), 3T3 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), IHC, WB Immunocytochemistry/Immunofluorescence: GCLM Antibody [NBP1-33405] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution. Western Blot: GCLM Antibody [NBP1-33405] - Sample (30 ug of whole cell lysate) A: H1299 12% SDS PAGE; antibody diluted at 1:5000. 100 μL Connectez-vous pour afficher 8 to 11 Days
$514.63
Détails
Humain Lapin Inconjugué ICC, IF, WB Western Blot: GCLM Antibody [NBP2-16624] - Sample (30 ug of whole cell lysate) A: C8D30 12% SDS PAGE gel, diluted at 1:1000. Immunocytochemistry/Immunofluorescence: GCLM Antibody [NBP2-16624] - Immunofluorescence analysis of methanol-fixed HeLa, using antibody at 1:200 dilution. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
$514.63
Détails
Humain Lapin Inconjugué IF, IHC, WB 100 μL Connectez-vous pour afficher 16 Days
$334.77
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-GCLM antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms ... 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of MCF7 cell lysate, using GCLM Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277512 at 1/100 staining Mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (55.88 KDa) . Dilution: 1:500~1000 100 μg Connectez-vous pour afficher 8 to 11 Days
$461.00
Détails
Humain Lapin Inconjugué ICC, IHC, WB Western Blot; Sample: Human A431 cell lysate; Primary Ab: 5µg/ml Rabbit Anti-Human GCLM Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant GCLM, Human. 100 μg Connectez-vous pour afficher 13 to 16 Days
$332.00
Détails

anti-GCLM Anticorps mieux référencés

  1. Human Monoclonal GCLM Primary Antibody pour ELISA, WB - ABIN516058 : Balamurugan, Akhov, Selvaraj, Pugazhenthi: Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. dans Pancreas 2009 (PubMed)
    Show all 4 Pubmed References

  2. Cow (Bovine) Polyclonal GCLM Primary Antibody pour IHC, WB - ABIN2785805 : Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. dans International archives of occupational and environmental health 2008 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal GCLM Primary Antibody pour ELISA, IHC - ABIN6261915 : Zou, Wang, Peng, Wei: Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells. dans Oxidative medicine and cellular longevity 2017 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal GCLM Primary Antibody pour ICC, IF - ABIN443275 : Lu, Samanta, Xiang, Zhang, Hu, Chen, Bullen, Semenza: Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. dans Proceedings of the National Academy of Sciences of the United States of America 2015 (PubMed)

  5. Human Polyclonal GCLM Primary Antibody pour FACS, IF - ABIN653046 : Moyer, Sun, Batzler, Li, Schaid, Yang, Weinshilboum: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. dans Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre GCLM partenaires d’interaction

Human Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 (Montrer GLI2 Anticorps) macrophages is tightly and differentially regulated via GCLC (Montrer GCLC Anticorps) and GCLM subunits of glutamate cysteine ligase (Montrer GCLC Anticorps).

  2. Two promoter polymorphisms of GCLM (-588C/T) and GCLC (Montrer GCLC Anticorps) (-128T/C) are associated with an increased risk of ischemic heart disease in Kazakhstan population.

  3. High GCLM expression is associated with chemotherapy resistance in breast cancer.

  4. Glutaminolysis is activated in ES2 (Montrer DGCR14 Anticorps) and OVCAR3, though ES2 (Montrer DGCR14 Anticorps) exclusively synthesizes amino acids and GSH. ES2 (Montrer DGCR14 Anticorps) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (Montrer DGCR14 Anticorps) to carboplatin. HNF1beta (Montrer HNF1B Anticorps) regulates the expression of GCLC (Montrer GCLC Anticorps), but not GCLM, and consequently GSH production in ES2 (Montrer DGCR14 Anticorps)

  5. Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (Montrer HMOX1 Anticorps)) and GCLM via activation of NRF2 (Montrer GABPA Anticorps)-ARE (nuclear factor erythroid 2-antioxidant response element) signaling.

  6. miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.

  7. Data suggest expression of hepatocyte GCLC (Montrer GCLC Anticorps) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (Montrer GCLC Anticorps) and GCLM expression.

  8. miR (Montrer MLXIP Anticorps)-320a has a role in modulating the induction of HO-1 (Montrer HMOX1 Anticorps), GCLM and OKL38 (Montrer OSGIN1 Anticorps) by oxidized phospholipids in endothelial cells

  9. This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (Montrer GCLC Anticorps).

  10. Knockdown of glutamate cysteine ligase catalytic subunit (Montrer GCLC Anticorps) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.

Mouse (Murine) Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. glutathione levels in the skin of Gclm knock-out mice are reduced by 70 %, which is sufficient for wound repair in young mice, but become rate-limiting upon aging

  2. Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.

  3. Upregulation of both GCLC (Montrer GCLC Anticorps) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  4. In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (Montrer PVALB Anticorps) interneurons and have long-term consequences.

  5. Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (Montrer PHB2 Anticorps).

  6. The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.

  7. Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.

  8. Clinically relevant levels of TGF-beta1 (Montrer TGFB1 Anticorps) suppresses GCLC (Montrer GCLC Anticorps) and GCLM expression in mouse lung.

  9. Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.

  10. Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.

GCLM profil antigène

Profil protéine

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

Gene names and symbols associated with GCLM

  • glutamate-cysteine ligase regulatory subunit (PTRG_09814) anticorps
  • glutamate cysteine ligase, modifier subunit (Gclm) anticorps
  • glutamate-cysteine ligase modifier subunit (GCLM) anticorps
  • glutamate-cysteine ligase, modifier subunit (gclm) anticorps
  • glutamate-cysteine ligase, modifier subunit L homeolog (gclm.L) anticorps
  • glutamate-cysteine ligase, modifier subunit (Gclm) anticorps
  • glutamate-cysteine ligase modifier subunit (Gclm) anticorps
  • AI649393 anticorps
  • Gcmc anticorps
  • GLCLR anticorps
  • id:ibd3182 anticorps
  • wu:fi24c07 anticorps
  • zgc:55903 anticorps

Protein level used designations for GCLM

glutamate-cysteine ligase regulatory subunit , GCS light chain , gamma-ECS regulatory subunit , gamma-glutamylcysteine synthetase regulatory subunit , glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory , glutamate--cysteine ligase regulatory subunit , glutamate-cysteine ligase modifier subunit , GSC light chain , glutamate--cysteine ligase modifier subunit , glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD) , glutamate-cysteine ligase modifier subunit delta2 alternative splicing , glutamate-cysteine ligase regulatory protein

GENE ID SPECIES
6348110 Pyrenophora tritici-repentis Pt-1C-BFP
29739 Rattus norvegicus
100352174 Oryctolagus cuniculus
333974 Danio rerio
380105 Xenopus laevis
424492 Gallus gallus
2730 Homo sapiens
525659 Bos taurus
14630 Mus musculus
100725164 Cavia porcellus
101117899 Ovis aries
100153977 Sus scrofa
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