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GPT2 encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis.
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GPT2 reduced alpha-ketoglutarate level in cells leading to the inhibition of proline hydroxylase 2 (PHD2 (Montrer EGLN1 Anticorps)) activity involved in the regulation of HIF1alpha (Montrer HIF1A Anticorps) stability. Accumulation of HIF1alpha (Montrer HIF1A Anticorps), resulting from GPT2-alpha-ketoglutarate-PHD2 (Montrer EGLN1 Anticorps) axis, constitutively activates sonic hedgehog (Shh (Montrer SHH Anticorps)) signaling pathway.
The GPT2 gene demonstrates increasing expression in brain in the early postnatal period, and GPT2 protein localizes to mitochondria. Akin to the human phenotype, Gpt2-null mice exhibit reduced brain growth. Through metabolomics and direct isotope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2
Recessively inherited loss of function GPT2 mutations are a novel cause of intellectual disability.
ATF4 (Montrer ATF4 Anticorps) silencing prevented the activating effect of histidinol and tunicamycin on ATF4 (Montrer ATF4 Anticorps) and ALT2 expression. Our findings point to ALT2 as an enzyme involved in the metabolic adaptation of the cell to stress
expression of GPT2 especially in muscle and fat, suggests a unique and previously unrecognized role of this gene product in glucose, amino acid, and fatty acid metabolism and homeostasis.
The biliary IL-6 (Montrer IL6 Anticorps) and TNF-alpha (Montrer TNF Anticorps) levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects.
Elevation of liver enzymes and hepatic insulin (Montrer INS Anticorps) resistance as reflected by fasting insulin (Montrer INS Anticorps) occur in the early stages of insulin (Montrer INS Anticorps) resistance and highlight the central role of the liver in insulin (Montrer INS Anticorps) resistance in the general population.
A clinical method for selective measurement of ALT1 (Montrer ALT Anticorps) and 2 in human plasma is described.
Data suggest that Alt2/Gpt2 (but not Alt1/Gpt1 (Montrer ALT Anticorps)) is induced in liver of obese mice (male ob/ob mice compared to lean C57BL/6J mice).
This gene encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
, alanine aminotransferase 2
, glutamate pyruvate transaminase 2
, glutamic--alanine transaminase 2
, glutamic--pyruvic transaminase 2
, glutamic-pyruvate transaminase 2
, glutamic pyruvate transaminase (alanine aminotransferase) 2
, glutamic pyruvate transaminase 2
, alanine aminotransferase 2-like