anti-Grainyhead-Like 3 (Drosophila) (GRHL3) Anticorps

GRHL3 encodes a member of the grainyhead family of transcription factors. De plus, nous expédions GRHL3 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GRHL3 57822 Q8TE85
GRHL3 230824 Q5FWH3
GRHL3 298555  
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Showing 10 out of 40 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-GRHL3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Placenta Host:  Rabbit  Target Name:  GRHL3  Sample Tissue:  Human 786-0 Whole Cell  Antibody Dilution:  1ug/ml 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-GRHL3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate Immunohistochemistry with Placenta tissue at an antibody concentration of 5µg/ml using anti-GRHL3 antibody (ARP39489_P050) 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB Anti-GRHL3 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959056 concentration 5 ug/ml. Anti-GRHL3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other f ... 100 μL 11 to 14 Days
Humain Lapin Inconjugué EIA, WB Western blot analysis of GRHL3 / SOM Antibody (N-term) in human placenta tissue lysates (35ug/lane).This demonstrates the GRHL3 antibody detected the GRHL3 protein (arrow). 0.4 mL 6 to 8 Days
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB 100 μL 11 to 14 Days
Humain Lapin Inconjugué ChIP, WB 100 μL 11 to 14 Days
Chien Lapin Inconjugué IHC, ELISA, WB 100 μL 2 to 3 Days
Humain Souris Inconjugué ELISA, WB Detection limit for recombinant GST tagged GRHL3 is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg 11 to 12 Days
Chien Lapin Inconjugué ELISA, WB 100 μL 2 to 3 Days
Humain Lapin Inconjugué ELISA, WB 100 μL 2 to 3 Days

anti-GRHL3 Anticorps mieux référencés

  1. Human Polyclonal GRHL3 Primary Antibody pour IHC - ABIN966223 : Ting, Wilanowski, Cerruti, Zhao, Cunningham, Jane: The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors. dans The Biochemical journal 2003 (PubMed)

  2. Cow (Bovine) Polyclonal GRHL3 Primary Antibody pour WB - ABIN2777797 : Yu, Mannik, Soto, Lin, Andersen: The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. dans The EMBO journal 2009 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal GRHL3 Primary Antibody pour IHC, WB - ABIN2781145 : Darido, Georgy, Wilanowski, Dworkin, Auden, Zhao, Rank, Srivastava, Finlay, Papenfuss, Pandolfi, Pearson, Jane: Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. dans Cancer cell 2011 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre GRHL3 partenaires d’interaction

Human Grainyhead-Like 3 (Drosophila) (GRHL3) interaction partners

  1. We identified rare damaging variants in four genes known to be mutated in syndromic lip and/or cleft palate (syCL/P) : TP63 (one family), TBX1 (one family), LRP6 (one family) and GRHL3 (two families), and clinical reassessment confirmed the isolated nature of their lip and/or cleft palate (CL/P).

  2. Hypomethylation of GRHL3 in central nervous tissue is associated with neural tube defects.

  3. Grainyhead-like 3 transcription factor is phosphorylated at many residues in cells. Cleft palate associated single nucleotide polymorphism abolishes threonine 454 phosphorylation. This residue is phosphorylated by the p38 MAP kinase. Threonine 454 is essential for regulation of GRHL3 activity by the p38 pathway.

  4. Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein

  5. The down-regulation of GRHL3 in vitro could inhibit colorectal cancer cell activity and trigger cell cycle arrest at G0/G1 phase and apoptosis.

  6. The data suggest that IRF6, TFAP2A, and GRHL3, among others, are shared in neural tube and orofacial development.

  7. Comparison of the variant rate between our cohort and the ExAC database identified a significant enrichment of deleterious variants in GRHL3 in the whole gene and the transactivation region in spina bifida patients. These data provide strong evidence for a role of GRHL3 as a predisposing factor to spina bifida and will help dissect the complex etiology and pathogenic mechanisms of these malformations

  8. mutations contribute to the risk of nonsyndromic cleft palate only in the African population

  9. All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT

  10. No association found between two GRHL3 SNPs (rs2486668 and rs545809) and non-syndromic orofacial clefts in the Han Chinese cohort.

  11. ey epidermal differentiation transcription factor genes, including GRHL3, are located within super-enhancers, and many of these transcription factors in turn bind to and regulate super-enhancers.

  12. GRHL3 expression may be useful as a prognostic factor.

  13. Study genotyped 10 tag SNPs covering GRHL3 and performed association analysis with nonsyndromic cleft lip with or without cleft palate in 504 cases and 455 healthy controls; preliminary results identified rs10903078, rs4638975, and a haplotype rs10903078-rs6659209 of GRHL3 that exceeded the significance threshold (p<0.05), though none survived Bonferroni correction for multiple comparisons.

  14. findings define a major role for Grhl3 in the induction of migration and invasion by the downregulation of E-cadherin in cancer cells

  15. We discovered a genome-wide significant association with a missense variant in GRHL3 and replicated the result in an independent sample of case and control subjects. In both samples, rs41268753 conferred increased risk for cleft palate.

  16. We identified both rare dominant mutations and a common risk variant in the coding region of GRHL3 as causative in individuals with nonsyndromic cleft palate only.

  17. GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]

  18. We defined a novel molecular signature in mammalian HNSCC, suggesting new treatment strategies targeting the GRHL3/GSK3B/c-MYC proto-oncogenic network.

  19. our results indicate predominant GRHL3 expression in breast cancers

  20. Our data demonstrated that mutations in two genes, IRF6 and GRHL3, can lead to nearly identical phenotypes of orofacial cleft.

Mouse (Murine) Grainyhead-Like 3 (Drosophila) (GRHL3) interaction partners

  1. we observed a striking additive genetic interaction between Grhl2 and Grhl3 gain-of-function alleles. moderate Grhl3 overexpression also interacted with the Vangl2Lp allele to cause SB, demonstrating genetic interaction with the planar cell polarity signalling pathway that is implicated in mouse and human neural tube defects.

  2. cytoplasmic localization of GRHL3 upon epidermal differentiation directly triggers epithelial morphogenesis.

  3. Diminished Grhl3 expression in the hindgut is the cause of spinal NTDs in the curly tail, carrying a hypomorphic Grhl3 allele. Complete loss of Grhl3 produces a more severe phenotype in which closure fails earlier in neurulation, before onset of expression in the hindgut of wild-type embryos. Abnormal surface ectoderm function, where Grhl3 mRNA is first detected, is responsible for early spinal neurulation failure.

  4. This study demonstrated that Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice.

  5. Findings suggest that transcription factor Grainyhead-like 3 (Grhl3) may be involved in the developmental pathogenesis of craniosynostosis.

  6. Based on the results, it proposes that developmental stage-specific Grhl3 plays a significant role in circumvallate papilla (CVP) morphogenesis not by just disruption of epithelial integrity but by regulating epithelial cell proliferation, apoptosis, and migration via Shh, Wnt, and apoptosis signaling during mouse embryogenesis.

  7. Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.

  8. This study identifies a GRHL3-regulated epidermal barrier repair pathway that suppresses disease initiation and helps resolve existing lesions in immune-mediated epidermal hyperplasia.

  9. decreased Grhl3 expression contributes to tumor progression and upregulation of the oncomir miR-21 in squamous cell carcinoma of the skin.

  10. The developmental transcription factor Grhl3 is a potent tumor suppressor of squamous cell carcinoma in mice.

  11. Both GRHL2 and GRHL3 bind to and regulate expression of the wound repair gene Rho GEF 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1), is unique to GRHL3.

  12. maps to Chromosome 4, 135 Mb (66 cM) from the centromere, probably not Idb3, Wnt4, Cdc42, perlecan or Grhl-3

  13. Loss of Grhl3 alone defines a distinct lower spinal closure defect, also with defective dorso-lateral hinge points formation

  14. folate deficiency caused a similar-sized, statistically significant increase in the frequency of exencephaly among both curly tail (Grhl3 mutant) embryos and background-matched embryos that are wild type for Grhl3.

  15. formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3[Grhl3]

  16. Unique role of Grhl3 in neurulation and epidermal morphogenesis.

  17. These findings indicate that the Get-1 and LMO4 genes interact functionally to regulate epidermal terminal differentiation.

  18. This study provides evidence for a critical role of diminished Grhl3 expression in causing spinal NTDs in the curly tail mouse model.

  19. The failure of eyelid closure is due to critical functions of Get1 in promoting F-actin polymerization, filopodia formation, and the cell shape changes that are required for migration of the keratinocytes at the leading edge during eyelid closure.

  20. Study demonstrates that the LIM-only domain protein, LMO4 serves as a functional partner of GRHL3 in its established roles, and define a new cooperative role for these factors in another developmental epidermal migration event, eyelid fusion.

GRHL3 profil antigène

Profil protéine

This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with GRHL3

  • grainyhead like transcription factor 3 (GRHL3) anticorps
  • grainyhead-like 3 (Drosophila) (Grhl3) anticorps
  • grainyhead-like transcription factor 3 (Grhl3) anticorps
  • AI561912 anticorps
  • ct anticorps
  • Get1 anticorps
  • GRHL3 anticorps
  • Som anticorps
  • Tfcp2l4 anticorps

Protein level used designations for GRHL3

grainyhead-like 3 (Drosophila) , sister-of-mammalian grainyhead protein , grainyhead-like protein 3 homolog , sister of mammalian grainyhead , sister-of-mammalian grainyhead , transcription factor CP2-like 4 , transcription factor hSOM1 , grainy head-like 3

419695 Gallus gallus
456630 Pan troglodytes
531906 Bos taurus
100057567 Equus caballus
57822 Homo sapiens
230824 Mus musculus
298555 Rattus norvegicus
487371 Canis lupus familiaris
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