anti-Granulin (GRN) Anticorps

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. De plus, nous expédions Granulin Kits (136) et Granulin Protéines (45) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Anticorps sur anticorps-enligne.fr

Showing 10 out of 166 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-87324] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87324] - Staining of human cell line A-431 shows positivity in vesicles. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$494.38
Détails
Humain Chèvre Inconjugué ELISA, WB EB08934 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$429.84
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-32076] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody diluted at 1:1000. Western Blot: Granulin Antibody [NBP1-32076] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
$516.98
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), WB WB Image Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. WB Image Mouse tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. 100 μL Connectez-vous pour afficher 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87325] Staining of human cell line U-251 MG shows positivity in vesicles. Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87325] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$494.38
Détails
Souris Lapin Inconjugué ICC, IHC, WB Western Blot; Sample: Mouse Kidney lysate; Primary Ab: 2µg/ml Rabbit Anti-Mouse GRN Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Connectez-vous pour afficher 13 to 16 Days
$360.00
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse brain lysates Lane 2: human colon carcinoma lysates probed with Anti alpha Actinin PGRN/Granulin Polyclonal Antibody, Unconjugated (ABIN728668) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 63kD. Observed band size: 63kD. 100 μL Connectez-vous pour afficher 3 to 7 Days
$329.45
Détails
Hamster Chèvre Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 11 to 14 Days
$610.50
Détails
Humain Chèvre Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 11 to 14 Days
$610.50
Détails

anti-Granulin Anticorps mieux référencés

  1. Human Polyclonal Granulin Primary Antibody pour WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. dans Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal Granulin Primary Antibody pour ELISA, WB - ABIN966227 : Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. dans Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal Granulin Primary Antibody pour IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. dans Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Granulin Primary Antibody pour ICC, IF - ABIN4315997 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. dans The Journal of clinical investigation 2011 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal Granulin Primary Antibody pour IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. dans Journal of autoimmunity 2015 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody pour ELISA, WB - ABIN439720 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. dans Neuro-degenerative diseases 2008 (PubMed)

  7. Human Polyclonal Granulin Primary Antibody pour ELISA, WB - ABIN561132 : Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. dans Oncogene 2015 (PubMed)

  8. Human Polyclonal Granulin Primary Antibody pour ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. dans Human molecular genetics 2011 (PubMed)

Plus d’anticorps contre Granulin partenaires d’interaction

Zebrafish Granulin (GRN) interaction partners

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. Our results suggest that decreased PGRN expression may contribute to the frequent occurrence of skin infections, but not progression, in patients with MF.

  2. The elevated progranulin levels are associated with obesity in infertile women.

  3. The combined CLU/PGRN serum level may be used as a potential serological marker for identifying patients with toluene diisocyanate (TDI)-induced occupational asthma among TDI-exposed workers.

  4. PGRN overproduction due to constitutively activated c-Abl/PKC-delta/Fli1 pathway may contribute to the resistance of localized scleroderma dermal fibroblasts to the anti-fibrotic effect of TNF-alpha, which may be involved in maintaining their pro-fibrotic phenotype under the pro-inflammatory condition, as is the case with systemic scleroderma.

  5. Task-based fMRI is highly sensitive to early GRN-related neurodegenerative changes even in conditions in which no behavioral differences were observed. Prefrontal activation may have utility as a biomarker for Predementia in GRN mutation.

  6. structural gray matter and white matter changes in presymptomatic progranulin mutation carriers

  7. C-peptide is increased in sporadic and GRN-mutated Frontotemporal lobar degeneration (FTLD) patients; resistin, an adipokine involved in inflammatory-related diseases, is specifically increased in FTLD due to GRN null mutations; ghrelin concentration is specifically increased in pre-symptomatic subjects and FTLD patients with GRN mutations.

  8. Taken together, we hypothesize that PGRN A9D leads to the retention of ANG in the cytoplasm to protect cells from PGRN A9D-induced apoptosis, implying that PGRN and ANG act in concert to regulate the progress of neurodegenerative disease.

  9. PGRN is associated with intervertebral disc degeneration through interfering with IL-10 and IL-17

  10. progranulin reduction might be the cause of multiple proteinopathies due to the accelerating accumulation of abnormal proteins including TDP-43 proteinopathy, tauopathy and alpha-synucleinopathy.

  11. Results suggest that serum PGRN levels are significantly higher in obese children in China and correlate significantly with obesity-related markers. Increased PGRN levels may be involved in the pathological mechanism of childhood obesity.

  12. Progranulin has a direct effect on tumor growth, migration, and invasion of human colon cancer cells. It may serve as a potential therapeutic target for human colon cancer.

  13. Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation.

  14. miR-29b-3p bound to PGRN in a direct manner. Transfection with si-PGRN correlated with elevated E-cadherin expression, decreased snail and vimentin expressions, as well as less-motivated cell proliferation and cell metastasis. The H19/miR-29b-3p/PGRN axis modulated epithelial-mesenchymal transition of NSCLC cells via Wnt/beta-catenin signaling.

  15. SNPs in GRN are not related to ankylosing spondylitis susceptibility in a Chinese Han population.

  16. Plasma progranulin levels predict the presence of GRN null mutations independent of proximity to symptoms and brain atrophy.

  17. Serum progranulin may have potential to be used as a biomarker for the differentiation between early-onset pre-eclampsia and late-onset pre-eclampsia.

  18. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  19. The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.

  20. This work identifies PGRN as an activator of lysosomal cathepsin D activity, and suggests that decreased cathepsin D activity due to loss of PGRN contributes to both FTD and NCL pathology in a dose-dependent manner.

Mouse (Murine) Granulin (GRN) interaction partners

  1. Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation.

  2. Progranulin deficiency decreased the number of microglia and retinal precursor cells.

  3. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  4. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  5. PGRN reduction from knock-in R504X mutation disinhibits Gas6 binding to Tyro3, resulting in activation of PKCalpha via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss

  6. PGRN haploinsufficiency may decrease accumulation of Abeta.

  7. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  8. Results from conditional progranulin-knockout mice that lack progranulin in nestin-expressing cells (Nes-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  9. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  10. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  11. findings suggest that PGRN deficiency leads to excessive NF-kappaB activation in microglia and elevated TNFalpha signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  12. PGRN plays a protecting role in hippocampal neurogenesis.

  13. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK activation.

  14. This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.

  15. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

  16. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  17. Study demonstrate that PGRN interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 aggregation observed in frontotemporal lobar degeneration with GRN mutations.

  18. Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X syndrome.

  19. highlight an important role for neuron-derived progranulin in maintaining normal social function.

  20. overexpression of PGRN was also found to increase activity of neprilysin, a key amyloid beta degrading enzyme. PGRN regulation of neprilysin activity could play a major role in the observed alterations in plaque burden

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) profil antigène

Profil protéine

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Anticorps

  • granulin precursor (GRN) anticorps
  • granulin a (grna) anticorps
  • Granulins (grn) anticorps
  • granulin L homeolog (grn.L) anticorps
  • granulin (granulin) anticorps
  • granulin (ORF1 granulin) anticorps
  • granulin precursor (Grn) anticorps
  • granulin (Grn) anticorps
  • acrogranin anticorps
  • CLN11 anticorps
  • DKFZp459H066 anticorps
  • epithelin anticorps
  • GEP anticorps
  • GP88 anticorps
  • grn anticorps
  • MGC53354 anticorps
  • PCDGF anticorps
  • PEPI anticorps
  • PGRN anticorps
  • wu:fb11g12 anticorps
  • wu:fj18f05 anticorps

Protein level used designations for anti-Granulin (GRN) Anticorps

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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