Granulin Protéines (GRN)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. De plus, nous expédions Granulin Anticorps (170) et Granulin Kits (135) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Showing 10 out of 45 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
HEK-293 Cells Humain Inconjugué 50 μg Connectez-vous pour afficher 2 to 3 Days
$810.00
Détails
HEK-293 Cells Rat DYKDDDDK Tag 50 μg Connectez-vous pour afficher 2 to 3 Days
$765.00
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
HEK-293 Cells Souris DYKDDDDK Tag 50 μg Connectez-vous pour afficher 2 to 3 Days
$765.00
Détails
HEK-293 Cells Souris Inconjugué 50 μg Connectez-vous pour afficher 2 to 3 Days
$810.00
Détails
HEK-293 Cells Rat Inconjugué 50 μg Connectez-vous pour afficher 2 to 3 Days
$810.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$340.00
Détails
Escherichia coli (E. coli) Humain His tag,S tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$448.00
Détails
Escherichia coli (E. coli) Souris His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$608.00
Détails

GRN Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , , ,
, , , ,
Rat (Rattus) , ,
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Mouse (Murine) , , ,
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Granulin Protéines mieux référencés

  1. Human Granulin Protein expressed in Wheat germ - ABIN1355792 : Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Show all 3 Pubmed References

Plus protéines pour Granulin (GRN) partenaires d'interaction

Zebrafish Granulin (GRN) interaction partners

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. PGRN overproduction due to constitutively activated c-Abl/PKC-delta/Fli1 pathway may contribute to the resistance of localized scleroderma dermal fibroblasts to the anti-fibrotic effect of TNF-alpha, which may be involved in maintaining their pro-fibrotic phenotype under the pro-inflammatory condition, as is the case with systemic scleroderma.

  2. Task-based fMRI is highly sensitive to early GRN-related neurodegenerative changes even in conditions in which no behavioral differences were observed. Prefrontal activation may have utility as a biomarker for Predementia in GRN mutation.

  3. structural gray matter and white matter changes in presymptomatic progranulin mutation carriers

  4. C-peptide is increased in sporadic and GRN-mutated Frontotemporal lobar degeneration (FTLD) patients; resistin, an adipokine involved in inflammatory-related diseases, is specifically increased in FTLD due to GRN null mutations; ghrelin concentration is specifically increased in pre-symptomatic subjects and FTLD patients with GRN mutations.

  5. Taken together, we hypothesize that PGRN A9D leads to the retention of ANG in the cytoplasm to protect cells from PGRN A9D-induced apoptosis, implying that PGRN and ANG act in concert to regulate the progress of neurodegenerative disease.

  6. PGRN is associated with intervertebral disc degeneration through interfering with IL-10 and IL-17

  7. progranulin reduction might be the cause of multiple proteinopathies due to the accelerating accumulation of abnormal proteins including TDP-43 proteinopathy, tauopathy and alpha-synucleinopathy.

  8. Results suggest that serum PGRN levels are significantly higher in obese children in China and correlate significantly with obesity-related markers. Increased PGRN levels may be involved in the pathological mechanism of childhood obesity.

  9. Progranulin has a direct effect on tumor growth, migration, and invasion of human colon cancer cells. It may serve as a potential therapeutic target for human colon cancer.

  10. Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation.

  11. miR-29b-3p bound to PGRN in a direct manner. Transfection with si-PGRN correlated with elevated E-cadherin expression, decreased snail and vimentin expressions, as well as less-motivated cell proliferation and cell metastasis. The H19/miR-29b-3p/PGRN axis modulated epithelial-mesenchymal transition of NSCLC cells via Wnt/beta-catenin signaling.

  12. SNPs in GRN are not related to ankylosing spondylitis susceptibility in a Chinese Han population.

  13. Plasma progranulin levels predict the presence of GRN null mutations independent of proximity to symptoms and brain atrophy.

  14. Serum progranulin may have potential to be used as a biomarker for the differentiation between early-onset pre-eclampsia and late-onset pre-eclampsia.

  15. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  16. The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.

  17. This work identifies PGRN as an activator of lysosomal cathepsin D activity, and suggests that decreased cathepsin D activity due to loss of PGRN contributes to both FTD and NCL pathology in a dose-dependent manner.

  18. MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN.

  19. Results provide evidence that progranulin destabilizes sortilin via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin thereby assuring the sustainable pro-tumorigenic actions of progranulin in castration-resistant prostate cancer.

  20. PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]

Mouse (Murine) Granulin (GRN) interaction partners

  1. Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation.

  2. Progranulin deficiency decreased the number of microglia and retinal precursor cells.

  3. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  4. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  5. PGRN reduction from knock-in R504X mutation disinhibits Gas6 binding to Tyro3, resulting in activation of PKCalpha via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss

  6. PGRN haploinsufficiency may decrease accumulation of Abeta.

  7. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  8. Results from conditional progranulin-knockout mice that lack progranulin in nestin-expressing cells (Nes-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  9. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  10. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  11. findings suggest that PGRN deficiency leads to excessive NF-kappaB activation in microglia and elevated TNFalpha signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  12. PGRN plays a protecting role in hippocampal neurogenesis.

  13. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK activation.

  14. This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.

  15. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

  16. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  17. Study demonstrate that PGRN interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 aggregation observed in frontotemporal lobar degeneration with GRN mutations.

  18. Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X syndrome.

  19. highlight an important role for neuron-derived progranulin in maintaining normal social function.

  20. overexpression of PGRN was also found to increase activity of neprilysin, a key amyloid beta degrading enzyme. PGRN regulation of neprilysin activity could play a major role in the observed alterations in plaque burden

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Profil protéine Granulin (GRN)

Profil protéine

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with Granulin Protéines (GRN)

  • granulin precursor (GRN)
  • granulin a (grna)
  • Granulins (grn)
  • granulin L homeolog (grn.L)
  • granulin (granulin)
  • granulin (ORF1 granulin)
  • granulin precursor (Grn)
  • granulin (Grn)
  • acrogranin Protéine
  • CLN11 Protéine
  • DKFZp459H066 Protéine
  • epithelin Protéine
  • GEP Protéine
  • GP88 Protéine
  • grn Protéine
  • MGC53354 Protéine
  • PCDGF Protéine
  • PEPI Protéine
  • PGRN Protéine
  • wu:fb11g12 Protéine
  • wu:fj18f05 Protéine

Protein level used designations for Granulin Protéines (GRN)

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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