anti-Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) Anticorps

The protein encoded by GZMH is a member of the granzyme family. De plus, nous expédions Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Kits (9) et Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Protéines (9) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GZMH 2999 P20718
GZMH    
GZMH    
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Top anti-Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) Anticorps sur anticorps-enligne.fr

Showing 10 out of 52 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Cheval Lapin Inconjugué IHC, WB WB Suggested Anti-GZMH Antibody Titration: 2.5ug/ml Positive Control: Jurkat cell lysate Human kidney 100 μL 2 to 3 Days
$249.00
Détails
Humain Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of Granzyme H staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Granzyme H staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ICC, IHC, WB Western Blot; Sample: Human Jurkat(7u) cell lysate; Primary Ab: 5µg/ml Rabbit Anti-Human GZMH Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant protein. 100 μg 13 to 16 Days
$386.00
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB 100 μL 11 to 14 Days
$507.83
Détails
Humain Lapin Inconjugué IF, ELISA, WB 100 μL 11 to 14 Days
$493.17
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB Western blot analysis Granzyme H using K562 whole cell lysates ABIN6272311 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué WB Western Blot analysis of GZMH expression in transfected 293T cell line by GZMH MaxPab polyclonal antibody.Lane 1: GZMH transfected lysate(27.06 KDa).Lane 2: Non-transfected lysate. GZMH MaxPab polyclonal antibody. Western Blot analysis of GZMH expression in human spleen. 50 μL 11 to 12 Days
$364.00
Détails
Humain Lapin Inconjugué IF, IHC (p), WB Immunohistochemistry (IHC) analyzes of Granzyme H antibody in paraffin-embedded human pancreas tissue. Western blot (WB) analysis of Granzyme H antibody in extracts from K562 cells. 0.1 mg 6 to 8 Days
$434.50
Détails
Humain Lapin Inconjugué IHC, ELISA, WB 100 μL 2 to 3 Days
$446.88
Détails
Humain Souris Inconjugué ELISA   100 μL 14 to 16 Days
$247.82
Détails

Plus d’anticorps contre Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) partenaires d’interaction

Human Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) interaction partners

  1. Granzyme H did directly process DFF45, potentially leading to DNA damage.

  2. Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition.

  3. An unusual RKR motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites.

  4. GzmH suppresses viral replication through association with the hepatitis B virus x protein.

  5. Granzyme C rapidly induces target cell death by attacking nuclear and mitochondrial targets and that these targets are distinct from those used by granzyme B to cause classical apoptosis.

  6. granzyme H complements the pro-apoptotic function of granzyme B in human NK cells

  7. Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition.

  8. Expression levels of GzmH in naive natural killer cells and its killing ability support the role of the protease in triggering an alternative cell-death pathway in innate immunity.

  9. GzmH may play an essential role in caspase-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB in human NK cells.

  10. Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B.

  11. Cleavage of La protein by granzyme H generates a COOH-terminal truncated form of La protein that loses nuclear localization and decreases hepatitis C virus-internal ribosome entry site-mediated translational activity.

Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) profil antigène

Profil protéine

The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene names and symbols associated with GZMH

  • granzyme H (LOC617313) anticorps
  • granzyme H (GZMH) anticorps
  • CCP-X anticorps
  • CGL-2 anticorps
  • CSP-C anticorps
  • CTLA1 anticorps
  • CTSGL2 anticorps
  • GZMH anticorps

Protein level used designations for GZMH

granzyme H , cytotoxic T-lymphocyte proteinase , cytotoxic T-lymphocyte-associated serine esterase 1 , cytotoxin serine protease-C

GENE ID SPECIES
617313 Bos taurus
100113476 Felis catus
2999 Homo sapiens
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