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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. De plus, nous expédions GZMM Kits (22) et GZMM Protéines (12) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal GZMM Primary Antibody pour ELISA, WB - ABIN516325
Schiffer, Letzian, Jost, Mladenov, Hristodorov, Huhn, Fischer, Barth, Thepen: Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells. dans Cancer letters 2013
GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.
We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.
Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.
GrM (Montrer TPST2 Anticorps) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (Montrer HNRNPK Anticorps) in the presence of RNA.
FADD (Montrer FADD Anticorps) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (Montrer CASP3 Anticorps) cascade.
Results indicate that cellular overexpression of SERPINB4 (Montrer SERPINB4 Anticorps) inhibits recombinant GrM (Montrer TPST2 Anticorps)-induced as well as NK cell-mediated cell death.
GrM (Montrer TPST2 Anticorps) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (Montrer F8 Anticorps) levels via proteolytic processing of its carrier VWF (Montrer VWF Anticorps).
Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.
survivin (Montrer BIRC5 Anticorps) cleavage by Granzyme M triggers degradation of the survivin (Montrer BIRC5 Anticorps)-X-linked inhibitor of apoptosis protein (XIAP (Montrer XIAP Anticorps)) complex to free caspase (Montrer CASP3 Anticorps) activity leading to cytolysis of target tumor cells
Granzyme M regulates the release of natural killer cell MIP-1alpha (Montrer CCL3 Anticorps) to initiate innate immune responses.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (Montrer TLR4 Anticorps))-toll (Montrer TLR4 Anticorps)-like receptor (TLR)4 (Montrer TLR4 Anticorps) signaling, which ultimately results in lethal endotoxicosis.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
, Met-1 serine protease
, lymphocyte met-ase 1
, natural killer cell granular protease
, lymphoctye Met-ase 1