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The product of GRB14 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. De plus, nous expédions GRB14 Kits (31) et GRB14 Protéines (11) et beaucoup plus de produits pour cette protéine.
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Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.
The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor (Montrer INSR Anticorps) signaling.
Data show that Grb14 inhibits the activity of PTP1B (Montrer PTPN1 Anticorps) in retina in a phosphorylation-regulated (Montrer PHAX Anticorps) manner, and that rhodopsin (Montrer RHO Anticorps)-regulated Src kinase (Montrer CSK Anticorps) activation in retina leads to the phosphorylation of Grb14.
Grb14 is a normal physiological modulator of CNG (Montrer CNGA1 Anticorps) channel function in vivo.
Grb14 functions in vivo as a tissue-specific modulator of insulin (Montrer INS Anticorps) action, most likely via repression of IR-mediated IRS-1 (Montrer IRS1 Anticorps) tyrosine phosphorylation
regulation of Grb14 expression in adipose tissue may play a physiological role in insulin (Montrer INS Anticorps) sensitivity
Grb14 exerts a dual role on the regulation by insulin (Montrer INS Anticorps) of hepatic metabolism. It inhibits insulin receptor (Montrer INSR Anticorps) catalytic activity, and as a sterol regulatory element binding protein (Montrer CNBP Anticorps)-1c maturation.
These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin (Montrer RHO Anticorps) photoexcitation may trigger signaling events alternative to the classical transducin (Montrer GNAT1 Anticorps) activation.
Grb10 (Montrer GRB10 Anticorps) and Grb14 have roles in regulation of insulin (Montrer INS Anticorps) signaling and glucose homeostasis
We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2 (Montrer UBE2E2 Anticorps), PTPRD (Montrer PTPRD Anticorps), VPS26A (Montrer VPS26A Anticorps) and KCNQ1 (Montrer KCNQ1 Anticorps) showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin (Montrer INS Anticorps) sensitivity.
The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor (Montrer INSR Anticorps) complex formation through phosphorylation, in addition to other domains.
Data suggest that GRB10 (Montrer GRB10 Anticorps) and GRB14 are both Ca2 (Montrer CA2 Anticorps)+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 (Montrer GRB10 Anticorps) and GRB14, as compared to a single one present in GRB7 (Montrer GRB7 Anticorps). (GRB10 (Montrer GRB10 Anticorps) = growth factor receptor-bound protein 10 (Montrer GRB10 Anticorps); GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 (Montrer GRB7 Anticorps) = growth factor receptor-bound protein 7 (Montrer GRB7 Anticorps))
Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis.
Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor (Montrer INSR Anticorps).
Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15 (Montrer TBX15 Anticorps)/WARS2 (Montrer WARS2 Anticorps), STAB1 (Montrer STAB1 Anticorps), PIGC (Montrer PIGC Anticorps), ZNRF3 (Montrer ZNRF3 Anticorps), GRB14
Modulation of mouse rod photoreceptor responses by Grb14 protein.
ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin (Montrer INS Anticorps) resistance.
Studies indicate that insulin receptor (IR (Montrer INSR Anticorps)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10 (Montrer GRB10 Anticorps)/14 and SH2B1 (Montrer SH2B1 Anticorps)/B2 adaptors.
Grb14 is the first negative regulator of CEACAM3 (Montrer CEACAM3 Anticorps)-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact
These findings suggest that Grb14 may play a regulatory role in granulosa cells during follicular deviation in cattle.
The growth factor receptor (Montrer RYK Anticorps) bound protein (Grb) 14 NPXY motif could be acting as a dominant negative for insulin receptor (Montrer INSR Anticorps) substrate (IRS)-1 (Montrer IRS1 Anticorps) functions in the retina.
Grb14 contains a phosphorylated insulin receptor interacting domain between the pleckstrin homolog) and SH2 domains that binds to and forms a specific complex with the cytoplasmic domain of IRbeta
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.
growth factor receptor-bound protein 14
, growth factor receptor-bound protein 14-like
, GRB14 adapter protein
, growth factor receptor bound protein 14