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The product of GRB14 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. De plus, nous expédions GRB14 Anticorps (43) et GRB14 Protéines (8) et beaucoup plus de produits pour cette protéine.
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Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.
The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor (Montrer INSR Kits ELISA) signaling.
Data show that Grb14 inhibits the activity of PTP1B (Montrer PTPN1 Kits ELISA) in retina in a phosphorylation-regulated (Montrer PHAX Kits ELISA) manner, and that rhodopsin (Montrer RHO Kits ELISA)-regulated Src kinase (Montrer CSK Kits ELISA) activation in retina leads to the phosphorylation of Grb14.
Grb14 is a normal physiological modulator of CNG channel function in vivo.
Grb14 functions in vivo as a tissue-specific modulator of insulin (Montrer INS Kits ELISA) action, most likely via repression of IR-mediated IRS-1 (Montrer IRS1 Kits ELISA) tyrosine phosphorylation
regulation of Grb14 expression in adipose tissue may play a physiological role in insulin (Montrer INS Kits ELISA) sensitivity
Grb14 exerts a dual role on the regulation by insulin (Montrer INS Kits ELISA) of hepatic metabolism. It inhibits insulin receptor (Montrer INSR Kits ELISA) catalytic activity, and as a sterol regulatory element binding protein (Montrer CNBP Kits ELISA)-1c maturation.
These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation.
Grb10 (Montrer GRB10 Kits ELISA) and Grb14 have roles in regulation of insulin (Montrer INS Kits ELISA) signaling and glucose homeostasis
We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 (Montrer KCNQ1 Kits ELISA) showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin (Montrer INS Kits ELISA) sensitivity.
The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor (Montrer INSR Kits ELISA) complex formation through phosphorylation, in addition to other domains.
Data suggest that GRB10 (Montrer GRB10 Kits ELISA) and GRB14 are both Ca2 (Montrer CA2 Kits ELISA)+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 (Montrer GRB10 Kits ELISA) and GRB14, as compared to a single one present in GRB7 (Montrer GRB7 Kits ELISA). (GRB10 (Montrer GRB10 Kits ELISA) = growth factor receptor-bound protein 10 (Montrer GRB10 Kits ELISA); GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 (Montrer GRB7 Kits ELISA) = growth factor receptor-bound protein 7 (Montrer GRB7 Kits ELISA))
Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis.
Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor (Montrer INSR Kits ELISA).
Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1 (Montrer STAB1 Kits ELISA), PIGC, ZNRF3, GRB14
Modulation of mouse rod photoreceptor responses by Grb14 protein.
ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin (Montrer INS Kits ELISA) resistance.
Studies indicate that insulin receptor (IR (Montrer INSR Kits ELISA)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10 (Montrer GRB10 Kits ELISA)/14 and SH2B1 (Montrer SH2B1 Kits ELISA)/B2 adaptors.
Grb14 is the first negative regulator of CEACAM3 (Montrer CEACAM3 Kits ELISA)-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact
These findings suggest that Grb14 may play a regulatory role in granulosa cells during follicular deviation in cattle.
The growth factor receptor (Montrer RYK Kits ELISA) bound protein (Grb) 14 NPXY motif could be acting as a dominant negative for insulin receptor (Montrer INSR Kits ELISA) substrate (IRS)-1 (Montrer IRS1 Kits ELISA) functions in the retina.
Grb14 contains a phosphorylated insulin receptor interacting domain between the pleckstrin homolog) and SH2 domains that binds to and forms a specific complex with the cytoplasmic domain of IRbeta
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.
growth factor receptor-bound protein 14
, growth factor receptor-bound protein 14-like
, GRB14 adapter protein
, growth factor receptor bound protein 14