anti-HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Anticorps

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. De plus, nous expédions HECW2 Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
HECW2 316395  
HECW2 57520 Q9P2P5
HECW2 329152 Q6I6G8
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Top anti-HECW2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 52 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Chèvre Inconjugué ELISA   100 μg 6 to 7 Days
$291.53
Détails
Humain Lapin Inconjugué IC, IF, WB Immunofluorescent analysis of HECW2 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of HECW2 expression in A549 (A), NIH3T3 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from LOVO/HepG2 cells, using HECW2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Disponible
$363.46
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of HECW2 Antibody (Center) in mouse brain tissue lysates (35ug/lane). This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB ABIN6275087 staining LOVO cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB HECW2 Antibody (Center)  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 400 μL 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué WB Western blot analysis in mouse brain tissue lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Détails
Poulet Chèvre Inconjugué ELISA   100 μg 11 to 14 Days
$507.83
Détails
Humain Souris Inconjugué ELISA, WB   100 μg 11 to 14 Days
$537.17
Détails

anti-HECW2 Anticorps mieux référencés

  1. Human Polyclonal HECW2 Primary Antibody pour ELISA - ABIN547338 : Nagase, Kikuno, Ishikawa, Hirosawa, Ohara: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. dans DNA research : an international journal for rapid publication of reports on genes and genomes 2000 (PubMed)

Plus d’anticorps contre HECW2 partenaires d’interaction

Human HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) interaction partners

  1. Ectopic expression of HECW2 causes the ubiquitination of HP1alpha and beta, thereby targeting them for proteasomal degradation.

  2. Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation.

  3. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability.

  4. HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans.

  5. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.

  6. Low HECW2 expression is associated with cervical cancer.

  7. NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition

Mouse (Murine) HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) interaction partners

  1. that circHECW2 regulated the EndoMT by directly binding to MIR30D, a significantly downregulated miRNA from miRNA profiling, which subsequently caused an increased expression of ATG5

  2. Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.

  3. NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt signaling pathway.

  4. Grk2 phosphorylates the C terminus of the Na-channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2

HECW2 profil antigène

Profil protéine

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity).

Gene names and symbols associated with HECW2

  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2) anticorps
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2) anticorps
  • E3 ubiquitin-protein ligase HECW2 (LOC531691) anticorps
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b (hecw2b) anticorps
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (hecw2) anticorps
  • A730039N16Rik anticorps
  • D030049F17Rik anticorps
  • Gm971 anticorps
  • HECW2 anticorps
  • mKIAA1301 anticorps
  • Nedl2 anticorps

Protein level used designations for HECW2

E3 ubiquitin-protein ligase HECW2 , HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase HECW2-like , e3 ubiquitin-protein ligase HECW2-like , HECT, C2 and WW domain-containing protein 2 , NEDD4-like E3 ubiquitin-protein ligase 2 , NEDD4-related E3 ubiquitin ligase NEDL2

GENE ID SPECIES
316395 Rattus norvegicus
424050 Gallus gallus
459844 Pan troglodytes
531691 Bos taurus
100055015 Equus caballus
100331355 Danio rerio
100411186 Callithrix jacchus
100444189 Pongo abelii
100469664 Ailuropoda melanoleuca
100560989 Anolis carolinensis
100602550 Nomascus leucogenys
57520 Homo sapiens
329152 Mus musculus
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