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Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. De plus, nous expédions HERV-FRD Provirus Ancestral Env Polyprotein Anticorps (54) et beaucoup plus de produits pour cette protéine.
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genetic predisposition in ERVFRDE-1 may be associated with an increased risk of preeclampsia. This polymorphism is possibly involved in the regulation of syncytin-2 expression in preeclamptic placenta.
N-glycans at residues 133, 312, 332 and 443 of syncytin-2 are required for optimal fusion induction, and that single-nucleotide polymorphism C46R, N118S, T367M, R417H, V483I and T522M can alter the fusogenic function of syncytin-2.
Decreased syncytin-2 and MFSD2 proteins in gestational diabetic placentas might cause abnormal syncytiotrophoblast formation and possibly be involved in the pathology
ERVWE1, ERVFRDE1 and ERV3 transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia.
These results thereby demonstrate that induced expression of Syncytin-2 is highly dependent on the interaction of bZIP-containing transcription factors to a CRE/AP-1 motif and that this element is important for the regulation of Syncytin-2 expression
MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion.
results further highlighted the existence of a correlation between the extent of the decrease in the expression levels of both syncytins 1 and 2 fusogenic proteins and the degree of severity of preeclampsia symptoms
Analysis of non-spliced ERVFRDE1 mRNAs and env mRNAs detected efficient splicing of endogenously expressed RNAs in trophoblastic but not in non-placental cells.
The crystal structure of a central fragment of syncytin 2 "fossil" ectodomain is reported, allowing a remarkable superposition with the structures of the corresponding domains of present-day infectious retroviruses
immunolocalized only in the villous trophoblast of the chorionic villi, at the level of cytotrophoblastic cells
findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not
Syncytin 2 expression illustrates the abnormal trophoblast differentiation observed in placenta of fetal T21-affected pregnancies.
expression decreased in preeclamptic placentas; may function as a second fusogenic protein for placental cell fusion
These results highlight the importance of Syncytin-2 in BeWo and primary human trophoblast cell fusion.
Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a endogenous retrovirus provirus on rat chromosome 12 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.
HERV-FRD provirus ancestral Env polyprotein
, HERV-FRD_6p24.1 provirus ancestral Env polyprotein
, endogenous retrovirus group FRD member 1
, envelope polyprotein
, syncytin 2
, envelope glycoprotein syncytin-A
, syncytin a