anti-Heat Shock 70kDa Protein 9 (Mortalin) (HSPA9) Anticorps

HSPA9 encodes a member of the heat shock protein 70 gene family. De plus, nous expédions HSPA9 Protéines (16) et HSPA9 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
HSPA9 3313 P38646
HSPA9 15526 P38647
HSPA9 291671  
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Top anti-HSPA9 Anticorps sur anticorps-enligne.fr

Showing 10 out of 235 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IP, IHC, WB Sample Type: 3. rat brain extract (80ug) Primary Antibody Dilution: 2ug/ml Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience Secondary Antibody Dilution: 1: 20,000 Image Submitted by: Yuzhi Chen University of Arkansas for Medical Science Sample Type: Mouse Brain Slices Red: primaryBlue: DAPIPrimary Dilution: 1:400 Secondary Antibody: Anti-Rabbit IgG Alexa 594Secondary Dilution: 1:400 Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt University of Seville 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Caenorhabditis elegans Souris Inconjugué ICC, IF, IP, IHC, ELISA, WB Grp75(S52A 42) human cell lines mix. 100 μg Connectez-vous pour afficher 3 to 4 Days
$448.50
Détails
Humain Lapin Inconjugué IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using HSPA9 antibody (ABIN5970207) at 1/500 dilution. Immunohistochemistry of paraffin-embedded rat ovary using HSPA9 antibody (ABIN5970207) at dilution of 1/100 (40x lens). 100 μL Connectez-vous pour afficher 11 to 16 Days
$426.40
Détails
Humain Lapin Inconjugué EIA, IF, IHC (p), WB Immunofluorescence analysis of COS7 cells, using GRP75 Antibody. The picture on the right is treated with the synthesized peptide. Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Connectez-vous pour afficher 11 to 13 Days
$768.40
Détails
Humain Lapin Inconjugué IHC (p), WB Anti- Grp75 Picoband antibody,IHC(P) IHC(P): Rat Kidney Tissue 100 μg Connectez-vous pour afficher 4 to 6 Days
$280.00
Détails
Souris Lapin Inconjugué IHC, WB Immunofluorescence analysis of U2OS cell using HSPA9 antibody. Blue: DAPI for nuclear staining. Western blot analysis of extracts of various cell lines, using HSPA9 antibody. 100 μL Connectez-vous pour afficher 13 to 14 Days
$393.25
Détails
Chien Souris Inconjugué FACS, ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: GRP75/HSPA9B/Mortalin Antibody (9F8) [NBP1-47801] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY GRP75/HSPA9B/Mortalin. Immunohistochemistry-Paraffin: GRP75/HSPA9B/Mortalin Antibody (9F8) [NBP1-47801] - Staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-GRP75/HSPA9B/Mortalin mouse monoclonal antibody. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
$587.60
Détails
Humain Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of GRP75 staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of GRP75 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of Grp75 / HSPA9 Antibody (Center) in K562 cell line lysates (35ug/lane). This demonstrates the HSPA9 antibody detected the HSPA9 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Souris Lapin Inconjugué IF, IHC, ELISA, WB Western blot analysis of extracts from COS7 cells, using GRP75 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using GRP75 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails

anti-HSPA9 Anticorps mieux référencés

  1. Mammalian Monoclonal HSPA9 Primary Antibody pour ISt, IHC - ABIN1304831 : Lawrence, Chau, Engebrecht: DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. dans PLoS genetics 2015 (PubMed)
    Show all 17 Pubmed References

  2. Caenorhabditis elegans (C. elegans) Monoclonal HSPA9 Primary Antibody pour ICC, IF - ABIN361740 : Kaul, Wadhwa, Komatsu, Sugimoto, Mitsui: On the cytosolic and perinuclear mortalin: an insight by heat shock. dans Biochemical and biophysical research communications 1993 (PubMed)
    Show all 12 Pubmed References

  3. Human Polyclonal HSPA9 Primary Antibody pour ELISA, ICC - ABIN6262098 : Li, Liu, Wang, Wang, Du, Xu, Zhang, Wang, Yang: The role of PGC-1α and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells. dans Toxicology 2017 (PubMed)

  4. Dog (Canine) Monoclonal HSPA9 Primary Antibody pour FACS, ICC - ABIN4316279 : Yan, Yu, Castro, Dixon: ERα36, a variant of estrogen receptor α, is predominantly localized in mitochondria of human uterine smooth muscle and leiomyoma cells. dans PLoS ONE 2017 (PubMed)

  5. Human Polyclonal HSPA9 Primary Antibody pour ICC, IF - ABIN4316281 : Morisaki, Yashiro, Kakehashi, Inagaki, Kinoshita, Fukuoka, Kasashima, Masuda, Sakurai, Kubo, Muguruma, Ohira, Wanibuchi, Hirakawa: Comparative proteomics analysis of gastric cancer stem cells. dans PLoS ONE 2014 (PubMed)

  6. Cow (Bovine) Polyclonal HSPA9 Primary Antibody pour IP, IHC - ABIN2779292 : Shi, Liu, Zhang, Qin, Zhang, Li, Chen: [Cloning and sequence analysis of the Meq gene of 4 Marek's disease virus isolates from China]. dans Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 2008 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre HSPA9 partenaires d’interaction

Xenopus laevis Heat Shock 70kDa Protein 9 (Mortalin) (HSPA9) interaction partners

  1. Hspa9 is an important mediator for pronephros development through modulation of pax8. Mitochondrial functions of hspa9 are likely to be involved in specification of pronephric cell fate.

Human Heat Shock 70kDa Protein 9 (Mortalin) (HSPA9) interaction partners

  1. Data from Oncomine showed that mortalin was highly expressed in serous ovarian carcinomas compared with corresponding normal controls. Similar results were found in Cancer Cell Line Encyclopedia analysis and in clinical specimens. High mortalin expression was associated with high histological grade and worse overall survival rate.

  2. Modulation of mitochondrial ERbeta expression by Grp75 inhibits triple-negative breast cancer tumor progression by activating mitochondrial function.

  3. Nfu is shown to bind to both chaperone proteins with binding affinities similar to those observed for IscU binding to the homologous HSPA9 and Hsc20, while Nfu can also stimulate the ATPase activity of HSPA9

  4. this data demonstrates that cells can sense complement activation at the plasma membrane and in response, swiftly send GRP-75 to this region in order to deactivate it

  5. role of HAPA9 and its interaction with other mitochondria-related genes are not genetic risk factors for PD or AD.

  6. mortalin (HSPA9) directly interacts with PP1alpha and MEK1/2 and facilitates PP1alpha-mediated dephosphorylation of MEK1/2 by promoting their physical interaction, which is important in determining cellular steady-state levels of phosphorylated MEK1/2 and, subsequently, MEK/ERK activity.

  7. Identify Mortalin as a significant independent prognostic factor, in addition to location, clinical stage, and perineural invasion, for survival of pancreatic ductal adenocarcinoma patients.

  8. these findings indicate that reduced levels of HSPA9 may contribute to TP53 activation and increased apoptosis observed in del(5q)-associated MDS.

  9. phosphorylation by ERK also regulates the association of HIF-1alpha with a so-far-unknown interaction partner identified as mortalin (also known as GRP75 and HSPA9), which mediates non-genomic involvement of HIF-1alpha in apoptosis.

  10. mortalin is an oncogenic factor.

  11. endocytosis vesicle enrichment of GRP75 by mitochondria trafficking upregulates clathrin-independent endocytosis through an actin cytoskeleton reorganization mechanism mediated by the concurrent activation of Cdc42 and RhoA.

  12. Mortalin is up-regulated in non-small cell lung cancer, and it may be a potential biomarker of prognostic evaluation and a molecular therapeutic target for patients with early stage of non-small cell lung cancer

  13. the mitochondrial stress chaperone mortalin is crucial for melanogenesis. the hyperpigmented keloid skin possesses significantly higher level of mortalin expression. mortalin is increased during oxidative stress and drug-induced melanogenesis. overexpression of mortalin causes an increase in pigmentation and its compromise leads to reduction in melanin content.

  14. These findings suggest a regulatory role of human miRNA pathway especially GRP75 protein and hsa-mir-126 in dengue virus replication.

  15. UBXN2A binds to mortalin's binding pocket within the substrate-binding domain of mortalin. UBXN2A increases stability of p53 protein targeted by the mortalin-CHIP E3 ubiquitin ligase.

  16. Thus Hspa9 regulates erythroid differentiation through ISC cluster assembly, providing a pathophysiological mechanism for an MDS subtype characterized by HSPA9 haploinsufficiency

  17. Study shows that Mortalin is upregulated in breast cancer, and may be a useful poor prognostic biomarker for patients with breast cancer.

  18. This study showed that human post-mortem tissue indicated co-localization of mortalin within astrocytes.

  19. Biallelic mutations in HSPA9 are associated with the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia.

  20. veratridine enhances transactivation of UBXN2A, resulting in upregulation of UBXN2A in the cytoplasm, where UBXN2A binds and inhibits the oncoprotein mortalin-2

Mouse (Murine) Heat Shock 70kDa Protein 9 (Mortalin) (HSPA9) interaction partners

  1. HMGB1 specifically induces the release of Th2 cytokines through GRP75-mediated enhancement of ER-Mitochondrial Ca(2+) transfer and ROS increased.

  2. Thus Hspa9 regulates erythroid differentiation through ISC cluster assembly, providing a pathophysiological mechanism for an MDS subtype characterized by HSPA9 haploinsufficiency

  3. This study demonstred that Mortalin expression in brain astrocytes.

  4. data imply a role for Hspa9 in B lymphopoiesis and Stat5 activation downstream of IL-7 signaling

  5. Matrin 3 interacts specifically with the heat shock proteins glucose-regulated protein 78, GRP75 and glutathione S-transferase pi isoform 2.

  6. down-regulation of mortalin may potentiate Abeta-mediated mitochondrial fragmentation and dysfunction in AD.

  7. the mortalin/DJ-1 complex guards against mitochondrial oxidative stress and is indispensable for the maintenance of hematopoietic stem cells

  8. Inflammatory response of microglial cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin.

  9. Knockdown of Hspa9 results in a decrease in hematopoietic progenitors resulting in myelodysplastic syndromes.

  10. Data show that RNAi-mediated down-regulation of GRP75 and GRP75-blocking antibodies, both of which inhibited macromolecular endocytosis.

  11. The asymmetric segregation of mortalin in the bipotent cell line and its uniform distribution in a committed, lineage-restricted cell line raises the possibility that it may play a role in cell fate determination

  12. Mortalin imaging was used in normal and cancer cells with quantum dotimmuno-conjugates.

  13. We propose that the differential regulation of mortalin in AD and by the APOE genotype is a cellular defense mechanism responding to increases in oxidative stress.

HSPA9 profil antigène

Profil protéine

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.

Gene names and symbols associated with HSPA9

  • heat shock protein family A (Hsp70) member 9 S homeolog (hspa9.S) anticorps
  • heat shock protein family A (Hsp70) member 9 (hspa9) anticorps
  • stress-70 protein, mitochondrial (LOC577721) anticorps
  • heat shock protein family A (Hsp70) member 9 (HSPA9) anticorps
  • heat shock protein 9 (Hspa9) anticorps
  • heat shock protein family A member 9 (Hspa9) anticorps
  • heat shock protein family A (Hsp70) member 9 (Hspa9) anticorps
  • 74kDa anticorps
  • Csa anticorps
  • GRP-75 anticorps
  • Grp75 anticorps
  • Hsc74 anticorps
  • Hsp74 anticorps
  • Hsp74a anticorps
  • hspa9 anticorps
  • Hspa9a anticorps
  • HSPA9B anticorps
  • Mortalin anticorps
  • MOT anticorps
  • Mot-2 anticorps
  • Mot2 anticorps
  • Mthsp70 anticorps
  • MTHSP75 anticorps
  • Pbp74 anticorps

Protein level used designations for HSPA9

heat shock 70kDa protein 9 (mortalin) , heat shock 70kDa protein 9B , Stress-70 protein, mitochondrial-like protein , heat shock 70 kDa protein 9B , stress-70 protein, mitochondrial , GRP-75 , heat shock 70 kDa protein 9 , 75 kDa glucose-regulated protein , stress-70 protein, mitochondrial-like , heat shock 70kD protein 9B , mortalin, perinuclear , mortalin-2 , p66-mortalin , peptide-binding protein 74 , GRP 75 , heat shock 70kDa protein 9B (mortalin-2) , C3H-specific antigen , heat shock protein 9A , heat shock protein cognate 74 , heat shock protein, 74 kDa, A , heat shock protein, A , p66 MOT , PBP74 , heat shock 70kDa protein 9A , mortalin , mtHSP70 , 70 kDa heat shock protein , Heat shock 70 kDa protein 9

GENE ID SPECIES
379314 Xenopus laevis
407910 Xenopus (Silurana) tropicalis
577721 Strongylocentrotus purpuratus
714506 Macaca mulatta
100020208 Monodelphis domestica
100034032 Equus caballus
100173869 Pongo abelii
100406895 Callithrix jacchus
100521183 Sus scrofa
100590864 Nomascus leucogenys
416183 Gallus gallus
3313 Homo sapiens
517535 Bos taurus
474697 Canis lupus familiaris
15526 Mus musculus
291671 Rattus norvegicus
100689405 Cricetulus griseus
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