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HNRNPD belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
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Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism.
Lnc_ASNR interacted with the protein ARE/poly (U)-binding/degradation factor 1(AUF1), which is reported to promote rapid degradation of the Bcl-2 (Montrer BCL2 Protéines) mRNA, an inhibitor of apoptosis. Lnc_ASNR binds to AUFI in nucleus, decreasing the cytoplasmic proportion of AUF1 which targets the B-cell lymphoma-2 (Bcl-2 (Montrer BCL2 Protéines)) mRNA.
in the present case, the identified mutations in HNRNPD and risk polymorphisms are plausible molecular players in the manifestation of CD.
AUF1 p45 (Montrer CASP1 Protéines) triggers the RNA switch in the flaviviral genome that is crucial for viral replication. These findings represent an important example of how cellular (host) factors promote the propagation of RNA viruses
AUF1 might be a potential player in renal tubulointerstitial fibrosis through modulation of TGF-beta (Montrer TGFB1 Protéines) signal transduction via posttranscriptional regulation of Nedd4L (Montrer NEDD4L Protéines).
Results indicate that the IL-6 (Montrer IL6 Protéines)/STAT3 (Montrer STAT3 Protéines)/NF-kappaB (Montrer NFKB1 Protéines) positive feedback loop includes AUF1 and is responsible for the sustained active status of cancer-associated fibroblasts.
Depletion of AUF1 abolishes the global interaction of miRNAs and AGO2 (Montrer EIF2C2 Protéines). AUF1 functions in promoting miRNA-mediated mRNA decay globally.
High AUF1 expression is associated with esophageal squamous cell carcinoma.
Arginine methylation improves the viral RNA chaperone activity of AUF1 p45 (Montrer CASP1 Protéines).
These results suggest that the post-transcriptional regulation of ATX (Montrer ENPP2 Protéines) expression by HuR (Montrer ELAVL1 Protéines) and AUF1 modulates cancer cell migration.
Control of ARE-mRNA decay by AUF1 represents a mechanism for adult stem cell regulation.
MEF2C (Montrer MEF2C Protéines) is a key effector of the myogenesis program promoted by AUF1.
hnRNP (Montrer HNRNPH2 Protéines) D is critically involved in LDLR (Montrer LDLR Protéines) mRNA degradation in liver tissue in vivo.
This study showed that arginines in the RGG domain of AUF1 are methylated, and AUF1-RGG peptides may be novel reagents that reduce macrophage activation in inflammation.
Mitochondrial biogenesis occurs in the presence of increased CUG-BP1 (Montrer CELF1 Protéines) and AUF1, suggesting that reductions in known mRNA destabilizing proteins likely does not contribute to exercise-induced mitochondrial biogenesis.
Data show that AUF1 binds and strongly activates the transcription promoter for telomerase catalytic subunit Tert (Montrer TERT Protéines).
These findings demonstrate that AUF1 regulates VEGF (Montrer VEGFA Protéines) expression, and this study identifies an RGG peptide that suppresses VEGF (Montrer VEGFA Protéines) gene expression.
30-kDa protein is a novel isoform of AUF1 family and is the main component of the DAP (Montrer DAP Protéines)-II complex that binds to the DAS (Montrer ube3a Protéines) sequence.
p16( INK4a) is also a modulator of transcription and apoptosis through controlling the expression of two major transcription regulators, AUF1 and E2F1 (Montrer E2F1 Protéines)
These results show that ElrA and AUF1 bind to cyclin B2 (Montrer CCNB2 Protéines) mRNA independent of cytoplasmic polyadenylation elements and function by binding other elements.
Concurrent binding and modifications of AUF1 and HuR (Montrer ELAVL1 Protéines) mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase (Montrer PEPCK Protéines) mRNA in kidney cells.
the renal proximal tubule, may require the remodeling of AUF1 binding to the elements that mediate the rapid turnover of PEPCK (Montrer PEPCK Protéines) mRNA.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
ARE-binding protein AUFI, type A
, heterogeneous nuclear ribonucleoprotein D0
, hnRNP D0
, AU-rich element RNA-binding factor 1
, AU-rich element RNA-binding protein 1
, RNA binding protein p45AUF1
, heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
, p37 AUF1
, RNA binding protein